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Generic Name: hyaluronidase (injectable) (HYE al ure ON i dase)
Brand Names: Amphadase, Hylenex, Vitrase

What is Vitrase?

Vitrase (hyaluronidase) is a genetically designed protein.

Vitrase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications.

Vitrase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Important information

Serious drug interactions can occur when certain medicines are used together with Vitrase. Tell your doctor about all your current medicines.

Before receiving Vitrase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).

Your doctor may perform a skin test before using Vitrase to see if you are allergic to hyaluronidase.

Before receiving this medicine

You should not be treated with Vitrase if you are allergic to hyaluronidase.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • furosemide (Lasix);

  • phenytoin (Dilantin);

  • a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);

  • aspirin or salicylates;

  • cortisone or ACTH (Corticotropin);

  • estrogens; or

  • an antihistamine (such as a cold or allergy medicine).

It is not known whether Vitrase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether hyaluronidase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby when using Vitrase.

How is Vitrase given?

Vitrase is injected under the skin, into a muscle, or into other tissues of the body.

A healthcare provider will administer your Vitrase injection.

Vitrase should not be injected into a vein (as an intravenous injection).

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Because you will receive Vitrase in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving Vitrase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Vitrase side effects

Get emergency medical help if you have signs of an allergic reaction ro Vitrase: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Common Vitrase side effects may include:

  • pain, itching, or redness where the injection was given; or

  • swelling in your hands, feet, or body areas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Vitrase?

Other drugs may interact with hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Vitrase injection.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vitrase only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 5.01. Revision Date: 2016-03-07, 10:23:39 AM.