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Vitrase Side Effects

Generic name: hyaluronidase

Medically reviewed by Last updated on Oct 26, 2023.

Note: This document contains side effect information about hyaluronidase. Some dosage forms listed on this page may not apply to the brand name Vitrase.

Applies to hyaluronidase: solution.

Serious side effects of Vitrase

Along with its needed effects, hyaluronidase (the active ingredient contained in Vitrase) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase:


Get emergency help immediately if any of the following symptoms of overdose occur while taking hyaluronidase:

Symptoms of overdose

Other side effects of Vitrase

Some side effects of hyaluronidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to hyaluronidase: injectable powder for injection, injectable solution.


Rare (less than 0.1%): Allergic reactions (e.g. urticaria, angioedema), anaphylactic-like reactions following retrobulbar block or intravenous injection[Ref]


Postmarketing reports: Local injection site reactions[Ref]


Postmarketing reports: Enhancement of adverse events of co-administered drugs; edema (reported most frequently in association with hypodermoclysis)[Ref]

Frequently asked questions


1. (2004) "Product Information. Vitrase (hyaluronidase)." Bausch and Lomb Americas, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.