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Hyaluronidase Pregnancy and Breastfeeding Warnings

Hyaluronidase is also known as: Amphadase, Hydase, Hylenex, Vitrase, Wydase

Medically reviewed on March 7, 2018

Hyaluronidase Pregnancy Warnings

Hyaluronidase has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. No complications have been reported when used during labor; however, the effect on the fetus is unknown. Hyaluronidase should only be used during pregnancy when benefit outweighs risk.

See references

Hyaluronidase Breastfeeding Warnings

There are no data on the excretion of hyaluronidase into human milk. The manufacturer recommends caution when administering hyaluronidase to nursing women.

See references

References for pregnancy information

  1. TGA. Therapeutic Goods Administration. Australian Drug Evaluation Committee "Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregancy. Available from: URL:" ([1999]):
  2. "Product Information. Vitrase (hyaluronidase)." Bausch and Lomb, Rochester, NY.
  3. "Product Information. Hylenex (hyaluronidase)." Halozyme Therapeutics, San Diego, CA.

References for breastfeeding information

  1. "Product Information. Vitrase (hyaluronidase)." Bausch and Lomb, Rochester, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.