Exenatide and Nausea: What Users Say (Page 4)

• TLS...
• Taken for 1 to 6 months
• August 29, 2013

For Type 2 Diabetes "I've been on this medication since 3/28/13. In June, my A1C was down to 6.4. My next appointment is the end of September. 6-8 weeks into using Bydureon, I started experiencing nausea approximately 24-48 hours after injection, which lasted for 24-72 hours. In June, my doctor suggested I stop the Bydureon because he didn't like that I was feeling sick for half of my week. I had 1 month of medication left, so I agreed to stick with it one more month. Nausea went away, but I still had no appetite. Now I'm experiencing stomach pain with movement 24 hours after injection. I see the doctor at the end of September."

• SPF...
• January 16, 2021

For Type 2 Diabetes "When I first began using Bydureon BCise, it worked great. I didn't have any side effects until after taking it for several months. Sometimes the nausea was mild, and other times it made me feel like I was near death, but after I began eating Greek yogurt before my injections, it definitely helped with the nausea. My biggest complaint is, after using Bydureon BCise over a year, I began having problems with just about every injection. I dealt with faulty injections for several months and finally decided to have my doctor switch me to something else."

• Fre...
• Taken for 1 to 6 months
• June 12, 2016

For Type 2 Diabetes "UPDATE: So I've been on Bydureon for 6 weeks. I do now get the itchy lumps at the injection site. The nausea I had in the beginning is gone. Blood sugars are much better. No weight loss to report and what little appetite suppression I had in the beginning is also gone. I am 40 lbs overweight and just absolutely struggle to lose 1 pound. I was really hoping this would work for me in losing weight. So far, nothing."

• Akm...
• Taken for less than 1 month
• April 15, 2015

For Type 2 Diabetes "I've been on Bydureon coming on three weeks, I just gave my third week shot today! The first week, about five days in, I got violently ill: abdominal cramps, vomiting, diarrhea. Contacted my doctor, but he really thought that it was the stomach virus, so he asked me to take it for one more week. Second week, I had some light nausea, but all went well. Just took my third shot this morning, and I don't know if I did anything wrong, but it burned going in, and now there's a lump on my thigh the size of a pea."

• cat...
• Taken for 1 to 6 months
• December 14, 2019

For Type 2 Diabetes "My second time on Bydureon Bcise. After 3 boxes, 12 weeks, although I had tolerable stomach problems before, these turned into full-blown nausea and diarrhea that has now lasted 4 days. It keeps blood sugar under control with no added medications, but I can't get more than 5 feet from the toilet. It's debilitating at this point. If I take Imodium AD, it does stop diarrhea, but promotes the nausea. Trying to keep from getting dehydrated as all I pass is water in the diarrhea. Trying to get this out of my system. I will not take another injection. Do not know what I will do. This med hits you unexpectedly. Don't know when it will make you sick. This is my second try with this med. Trulicity doesn't work nor anything else for that matter. This med works for blood sugar, but I'm horribly sick."

• Don...
• November 18, 2010

For Type 2 Diabetes "I started Byetta in 2005, sugars were between 300-350. My weight was around 320, also. I had horrid nausea. I threw up a lot too. My sugars immediately dropped to normal, though. Now, looking back on it, I think I just ate all the wrong foods. I've been off and on Byetta over the years, depending on which insurance I have had. I just started it back up two days ago after going off last month to try Onglyza. My weight is now 213, by the way."

• Dal...
• Taken for 1 to 2 years
• August 24, 2019

For Type 2 Diabetes "When I started taking Bydureon, it was great. I lost 4 kg over 3 months, it made a huge difference. After about 6 months, I started having stomach issues. I was nauseated most days, and I spoke to my diabetic educator about going back on insulin, but they suggested I stay on the Bydureon for another 6 months. Those 6 months were the absolute worst. I now have constant stomach issues, gastroparesis is my main issue. I never had this before I started Bydureon, but my GP or DE are unwilling to take me off it, so I have stopped myself. After 1 month, I feel so much better, nausea is way less. My experience with Bydureon has been overwhelmingly negative."

• Fee...
• Taken for less than 1 month
• August 14, 2017

For Type 2 Diabetes "I have been on Bydureon for just under a week. I have not been able to eat very much. I am nauseous every day and have very little energy. I've been considering going to see my doctor to see what's wrong with me, but I see from these messages that it's probably from the injection. Of course, I've lost a few pounds because I cannot eat anything. I HATE HOW I FEEL!"

• Mat...
• Taken for 1 to 6 months
• March 28, 2019

For Type 2 Diabetes "I have been on Bydureon on 2 different occasions over the last year. The first time I took it for about 3 months. I quit because I was getting very lightheaded and nauseous, as well as my sugar would drop very low after an injection. After about 6 months, I thought I'd try again. I changed my injection time to after a meal and would skip my metformin at that meal. It seemed to take care of the sugar crash, but still feel awful most of the time. Nausea, loss of appetite, and lethargic. I think I'll just stop again. P.S. It did work. My A1C dropped from high 7's to low 6's. Just miserable with the side effects."

• Cam...
• April 25, 2018

For Type 2 Diabetes "My husband has been on Bydureon for 8 weeks. He was due for his 9th injection on Sunday last week but fell really ill about 24 hours after his 8th injection. It's now been 8 days since he fell ill with nausea, burping, heartburn, and constipation, with the occasional vomiting. How long until he will start to feel some normality? He has now had 6 days off work, and all he does is sleep. HELP."

• Nan...
• Taken for 1 to 6 months
• March 27, 2018

For Type 2 Diabetes "Added Bydureon to my usual metformin dose in June 2017. Had six months of persistent nausea, vomiting, diarrhea, and increasing sensation of liver fullness/discomfort. (It looks like I'm one of the group described by the package insert, who develop significant adverse effects.) At the injection sites, developed firm nodules that each took 2-3 months to resolve and became itchier the longer I was on the medication. I lost about 10 lb and had great readouts on A1c, but couldn't bear to take Bydureon beyond December 2017. In my view, not a success therapeutically."

• Hot...
• Taken for 1 to 6 months
• September 15, 2017

For Type 2 Diabetes "I've been taking Bydureon for 4 weeks now and have lost 5 kg. The only side effects I have had are heartburn, nausea, and headaches, but they have stopped. I do recommend this drug to anyone. It does suppress the appetite really well. I take it with Metformin. I get it through prescription, which costs $5.60 a month."

• SBi...
• October 28, 2015

For Type 2 Diabetes "All was fine the first week, a little nausea. Second week was fine as well, but a little redness/itching around the injection site. Third week, the injection site immediately started to turn into a giant hive across my entire abdomen, and I broke out in hives in all other areas of my body. Went to the ER and was taken off medication, but it took over a week for the serious reaction to stop. Developed 1-inch knots at all injection sites, which lasted for a couple of months. I've been off the meds for several months and still break out in hives around my waist and on my bra line. Prior to the first hive outbreak, I had never had allergic reactions to anything."

• Geo...
• Taken for less than 1 month
• April 27, 2016

For Type 2 Diabetes "I am on my third injection of Bydureon. The needle is huge, and the med burns going in and bleeds after. No problems with the injection site till this week, I noticed a small pea-sized bump at the first injection site on my stomach. The first two weeks, my morning sugars went up significantly to 190-200. Other side effects are diarrhea (which has resolved this week), bloating, a very uncomfortable full feeling, and some random stomach pain. This week numbers are starting to come down to 145-155, but still higher than when on my previous med, Victoza, which made me very nauseous. Not losing weight. In fact, I am up 2 lbs. Hope this turns around in the next couple of weeks."

• aa1...
• July 19, 2017

For Type 2 Diabetes "A few years ago, I started with Trulicity, then insurance made me switch to Tanzeum, and now I had to switch to Bydureon. A couple of issues: the corkscrew on my second box. When I twist the green, I hear the click, and the medicine window only has part of the liquid, the base has pushed out some of the medicine into the cap. I take off the needle cap, and there is liquid in the cap at $125 a pen. So, either I have a bad box of four, or there is a defect on these. It did not happen on box one, but on box two, the first two pens had this. The first and second-day side effects for me are horrendous: nausea and just feel awful. I never had these issues with prep or side effects with either Trulicity or Tanzeum. But it's all up to insurance companies in the end, they decide what is best for you."

• T27...
• August 26, 2017

For Type 2 Diabetes "I have been on it for 8-9 weeks. The only side effect I have had outside the last two days is loss of appetite, which is wonderful for a binge eater like myself. You not only get full sooner, you almost feel sick. I don't mind, it reminds me I need to keep myself in check. Until the last two days, I have not had the nausea and vomiting others seem to have. I don't know why it decided to start. I vomited two days in a row now. Hope it doesn't continue, I otherwise love it."

• Min...
• Taken for 2 to 5 years
• July 28, 2018

For Type 2 Diabetes "My husband has been taking Bydureon for two and a half years. His sugars are down, but he experienced nausea, headaches, and loss of appetite at the beginning. He has lost some weight also without doing any extra exercise. He still has a general feeling of not knowing what he wants to eat - he complains that food has no taste. He used to eat cereal for breakfast, but now sometimes only eats 1 meal a day and makes up for it with noodles, etc. Will his diet ever get back to normal?"

• Mrm...
• Taken for 6 months to 1 year
• March 3, 2021

For Type 2 Diabetes "On weekly Ozempic, I had extreme side effects such as nausea, headache, body ache, fatigue, and extreme brain fog, but it did work much better than metformin at lowering my blood sugar. Bydureon once a week worked just as well at lowering my sugar levels, and the side effects were less, although pretty much similar, just not quite as bad. My only other complaint is that the Bydureon delivery injector is a monstrous device that seems like it was designed by Rube Goldberg, and there is always one out of four doses that seemingly has no effect, like they slip a placebo dose in every month's supply for some reason! (P.S., I recommend B vitamins while taking diabetic drugs, they tend to keep you from absorbing certain essential nutrients for some reason, especially B vitamins.)"

• Daw...
• Taken for less than 1 month
• March 18, 2015

For Type 2 Diabetes "I have an A1C of 6.2. I am 265 pounds. I just started Bydureon yesterday, my Dr. office gave me the first one free, and I gave myself the first injection. I have had some mild nausea. I have not had the desire to eat very much and, in fact, went to bed without eating any dinner, had an overall odd full feeling. I am nervous because I have seen so many reviews of people that had a lot of nausea and vomiting. So far, so good, but it still worries me. I really want to lose weight and feel better."

• Min...
• Taken for 1 to 6 months
• August 9, 2018

For Type 2 Diabetes "To Brownie... I have taken Bydureon for 3 months and had some symptoms like yours. I also had a dull ache in my upper right abdomen under my ribs. Mine also is not gallbladder, liver, or pancreas. I felt sick, nauseated, had periodic vomiting, no energy, nodules at injection sites, itching, cellulitis, burping, bloating, and in general have to force myself to do things. I stopped taking Bydureon 2 weeks ago and am starting to feel better. I still have the nausea and bloating. When I started, I was told side effects decrease after 2 weeks, but I felt worse the longer I took it. It did decrease my readings, from the 300s to the 150s...still not that great but better. I read it can take up to 10 weeks to be completely out of your system."

• Phe...
• Taken for less than 1 month
• June 11, 2019

For Type 2 Diabetes "I took three doses of Bydureon. Each left lumps under my skin for weeks, but the third one gave me an 8x6 inch rash that would not calm down for weeks and itched like crazy. The first two injections did not have this reaction. I experienced severe nausea and headaches and had to be prescribed an anti-nausea medication. It was so bad I missed two days of work. I never got to the point where my blood sugar could be tested to see if the drug was effective because I stopped taking it. Luckily, my A1C marked me as borderline diabetic, so I managed my blood sugar with diet and exercise instead. All bodies are different, but this medicine was not for me."

• Arm...
• Taken for 1 to 6 months
• November 1, 2017

For Type 2 Diabetes "I am a 70-year-old male and have been taking diabetic medication for 10 years or more. The last two years I have been increasing my injections with little success in lowering my A1C. I started using Bydureon 6 weeks ago. The first two weeks were pretty rough: nausea, tired, headache. Week 6, no ill symptoms. Blood sugar has averaged 95, I have been taking it 3 to 4 times a day. No lumps. Needle and pen are pretty intimidating."

• Fem...
• Taken for 1 to 6 months
• June 20, 2016

For Type 2 Diabetes "Have completed the eighth (8th) week of Bydureon injections. Med physician prescribed not approved by the insurance carrier, and this was their substitute after 2 weeks on the previous. No nausea at any point (was warned both by the physician and literature this would definitely occur). Prior 2-week med controlled appetite, do not see where Bydureon has this effect. First 4 or 5 weeks seen slight weight loss of less than 2 lb per week, but this has subsided, and actually the last 2 weeks have shown a reversal. Will say have a more positive outlook 4 days after injection, and this subsides. Pharmacist said Bydureon has more of the ingredient I need, however, I believe personally benefit daily rather than weekly injections. Most likely will discuss this next Dr. visit."

• Anonymous
• Taken for less than 1 month
• July 1, 2017

For Type 2 Diabetes "Started Bydureon 3 days ago. I was sure I would be sick when I started it, as I was instantly sick on Byetta in the past. I was not nauseated at all on Bydureon. Bydureon was a painless shot, and I have had no side effects so far. I was on Victoza (2 years) and Trulicity (1 year). Victoza gave me major headaches when I first started it and eventually caused me to gain weight in the end. Trulicity made my blood sugar go all over for the first month and gave me some pretty serious random nausea. In the end, it too felt like it was becoming less effective. I am hoping Bydureon is a good medication for me. Will report more later."

• aus...
• Taken for 1 to 6 months
• November 29, 2016

For Type 2 Diabetes "I have been taking Byetta & Lantus for 3 months. I'm allergic to metformin. My blood glucose has been very high, 22.8 being the highest and average 12-13. Now the highest is 18.2, average 10-14, fasting morning readings 9-10, which is still very high. I'm ambivalent with my feelings of Byetta. I am disappointed as I really thought it would work brilliantly for me. I've always had nausea as the main side effect. Its severity varies, some days it's shocking, other days it dissipates with ginger tea, but it's never not been there! I have a review with my GP, which will up Byetta to 10 mcg, and then review with the endocrinologist in 2 months, where he might restart me on a brand new protocol, which might be a good thing as this clearly isn't working."