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Estradiol / norethindrone for Postmenopausal Symptoms User Reviews (Page 2)

Brand names: CombiPatch, Activella, Mimvey, Amabelz, Mimvey Lo, Etyqa, Ena, Lopreeza

Estradiol / norethindrone has an average rating of 6.5 out of 10 from a total of 80 reviews for the treatment of Postmenopausal Symptoms. 59% of reviewers reported a positive experience, while 28% reported a negative experience.

Reviews for Estradiol / norethindrone

  • rob...
  • Taken for less than 1 month
  • October 25, 2013

CombiPatch (estradiol / norethindrone) "I've been on this patch for a short period of time, however, I can say it works fast !!! On the 2nd day using this product, my flashes and night sweats were less severe ! I did experience nervousness on the 1st day, it lasted just a few hours hours then went away. So far, so good."

8 / 10
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34 Report
  • Lisa...
  • Taken for less than 1 month
  • December 28, 2019

Activella (estradiol / norethindrone) "I've been taking Activelle it's been a week for menopause issues, I have more hot flashes which was my reason for starting this medication. I was hoping it would improve my sleep....I'm disappointed in this medication..."

2 / 10
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17 Report
  • Lou
  • Taken for 5 to 10 years
  • May 2, 2019

Activella (estradiol / norethindrone) "I was prescribed Activella for 5 years. It worked beautifully for me and I felt good. I changed to Prempro because of insurance and about 3 weeks into that change I started developing breast tenderness, headache, and sleep issues. Unfortunately, I have to wait until October when I can change my insurance again to get back on Activella."

10 / 10
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19 Report
  • DrRiff
  • Taken for 5 to 10 years
  • May 19, 2013

Activella (estradiol / norethindrone) "I was prescribed this medicine for intractable migraines that seemed to be associated with decreased estrogen and for awful night sweats and insomnia. The migraines almost completely disappeared, and are now stopped with 50 mg Imitrex (that had previously gotten to the point where nothing stopped them). The nights sweats and insomnia completely stopped. "

10 / 10
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34 Report
  • JMano
  • Taken for 1 to 6 months
  • December 14, 2018

CombiPatch (estradiol / norethindrone) "I was diagnosed with sudden Early menopause. Severe migraines (worst than I ever had), Anxiety and panic attacks, insomnia (barely sleeping), depression and night sweats. I really started feeling 90% better with-in a couple weeks. I’m sleeping. Anxiety is minimal and I’m sleeping again. Minimal side effects, but I’ve had bloating and bad indigestion."

8 / 10
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20 Report

Are you taking this medicine?

  • Happy...
  • Taken for 5 to 10 years
  • September 5, 2019

CombiPatch (estradiol / norethindrone) "I have been on and off CombiPatch (due to working out of the United States) for the past 10 years and it wasn't available. I just resumed taking it and have been experiencing cramping and vaginal bleeding on and off for the past two months. My doctor and I are taking a conservative approach and are waiting a period of time for my body to adjust before we take any further action. I am comfortable with this for the time being. Next step if the bleeding doesn't stop would be to order an ultrasound of my Uterus."

9 / 10
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17 Report
  • Marie...
  • December 27, 2010

Activella (estradiol / norethindrone) "Hot flashes were relieved; however I suddenly (never before experienced) a migraine with some nausea after 2 months on this medicine. I used ES Tylenol and felt better in 3 hours. Since this is the only medication I was taking and my overall health is very good, I decided to reduce the dosage by taking the medication every other day. The hot flashes were still relieved and this half dosage was for one month. Last week I suffered another migraine and vomiting and was under the weather for an entire day. I have decided to go off the medication completely."

5 / 10
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36 Report
  • DYH
  • May 2, 2016

CombiPatch (estradiol / norethindrone) "I was post menopausal and dying with night sweats and continual hot flashes. I felt horrible and had for some time. I finally asked my doctor for help and he recommended CombiPatch. It worked wonderfully. I have used it for years and my doctor said I may have to use it the rest of my life. Problem right now is this..............it is back ordered from the manufacturer and I am now back into full blown menopause. Oh, my. I am wondering what is wrong and if it will ever be available again. The price may be making it not an option for many. I am going to ask for a replacement even though I loved this medication."

10 / 10
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24 Report
  • Delight
  • Taken for 10 years or more
  • February 27, 2018

CombiPatch (estradiol / norethindrone) "I have been using this product for years, and I hate to go without it. I sleep well, no hot flashes, mood is reasonably stable, no vaginal dryness. At one point when I was without it while waiting for my script to fill, I KNEW how much it was helping me. All good, and it is easy to use. Unfortunately it is expensive and not always in stock. My current medication insurance does not cover the whole price but it will be helpful once I hit my deductible. In the meantime, it is pricey. There are no good coupons that I have been able to find."

9 / 10
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19 Report
  • Saltena
  • Taken for 1 to 6 months
  • February 11, 2022

CombiPatch (estradiol / norethindrone) "Works great for me. No more hot flashes! Vaginal prolapse is less bothersome! Some minor spotting weeks 3-5 but not enough to use a liner or pad. The adhesive sticks fine and does not cause me skin irritation. I am 3 yrs post menopausal and wish I had started combipatch sooner!"

10 / 10
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8 Report
  • Nicole
  • Taken for less than 1 month
  • September 12, 2021

CombiPatch (estradiol / norethindrone) "I have been going through full-blown menopause for 8 years, plus I was in peri menopause for 3 years prior to that. I have not taken hormone replacement therapy up to this point. However, after my skin, hair and nails getting even dryer, no sex drive and have not been able to have intercourse with my husband for about 3 years, because the pain was too unbearable, I decided to try HRT. My doctor put me on the combipatch. At first, I did not have any side effects, but I have had constant bleeding for the last 2 weeks with mild cramping and bloating. I found myself barely being able to hold my eyes open around 4 pm every day and was having to sleep. This was my first month being on it and I have one patch left. At the end of the 7th patch, I took it off and did not put my last patch on. It has been 3 days now with no patch and I am still bleeding, cramping, and bloating. This has been horrible. I will deal with the hot flashes. I have dealt with them for 11 years...better than HRT."

1 / 10
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9 Report
  • Aidyl
  • Taken for 5 to 10 years
  • November 18, 2023

Activella (estradiol / norethindrone) "6+ years into taking Activella 1mg estradiol. Now aged 63. It improved my life and depression with menopause. *Had taken birth control pills most of my adult life. Don't feel I would ever go off Activella. No side effects. I have low thyroid since 2004, and since COVID am now COPD for the past year. So anything that improves my now shorter life is a blessing. Thank you."

10 / 10
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2 Report
  • Debora...
  • July 8, 2013

CombiPatch (estradiol / norethindrone) "My menopausal symptoms do not include hot flashes, only some night sweets. But my taking this medicine is to sleep better. I was not sleeping, only 2 hours than 3 hours. I did not want to take sleeping pills forever. Also, I am gaining weight. These are the Pros and Cons of the patch for me."

6 / 10
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25 Report
  • SlowC...
  • Taken for 6 months to 1 year
  • December 7, 2022

CombiPatch (estradiol / norethindrone) "I’m 48, been on combipatch for almost a year. For the first 6 months I was on the low dose - which was great and alleviated many symptoms: hot flashes, sleeplessness, anxiety, and weight gain in the midsection. I changed to the higher dose in May and felt great so I thought I could go back down to the lower dose in Sept., but that was a mistake. I just went back to the higher dose again and I’ll see how it goes in the winter. I did develop an allergic reaction to the adhesive but my dermatologist prescribed cortisone cream, I apply a bit to my skin and let it dry and the patch can be tolerated! Also, I do follow a lot of the Galveston Diet protocols and it helps immensely. I feel like I do a lot just to feel like myself, but it’s worth it."

9 / 10
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5 Report
  • Tywanna
  • Taken for 2 to 5 years
  • August 16, 2021

CombiPatch (estradiol / norethindrone) "I truly believe the combi patch caused my breast cancer. I started on the patch in 2018 and was diagnosed in 2021. Just make sure your Obgyn knows how to check your hormone levels!! It’s Not worth the risk!!!"

1 / 10
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8 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 5, 2015

CombiPatch (estradiol / norethindrone) "My symptoms were slight including flashes at night and some insomnia. Vaginal dryness was another concern. The patch has really helped. It's been almost a year since I started the patch. Early on I had some spotting, but that has stopped. I am having some puffiness in the application area."

10 / 10
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20 Report
  • Bea
  • Taken for 6 months to 1 year
  • May 12, 2021

Activella (estradiol / norethindrone) "Been taking Activelle for 7 months now, no hot flushes but still got night sweats. I will be stopping tomorrow as have been diagnosed with deep vein thrombosis in my calf today. So gave me worst symptoms would rather have the hot flushes back. Caution when taking this drug"

1 / 10
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8 Report
  • Jai
  • Taken for 2 to 5 years
  • October 6, 2018

CombiPatch (estradiol / norethindrone) "To anonymous, Combipatch is expensive when paying out-of-pocket. Check with your insurance. As for effectiveness, it really works for hot flashes and night sweat. I’ve been using it for the last three years."

9 / 10
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12 Report
  • KMano
  • Taken for 10 years or more
  • July 27, 2021

CombiPatch (estradiol / norethindrone) "I was on CombiPatch for many years but had to go off of it about a year ago after retiring. Unfortunately, Medicare does not cover CombiPatch. Although I am not sure that it is totally due to going off Combipatch patch, I have experienced many changes over the last several months. Those include return of hot flashes, difficulty sleeping, extreme memory loss and brain fog, irritability sense of sadness, possibly depression, achy joints, and just no joy in my life. I spoke to my GYN about it at my annual yesterday. The out-of-pocket cost of CombiPatch for me would be almost $230 a month and I cannot afford that. Due to this, we are going to try a generic estrogen patch and an oral progesterone tablet. I’ll see how that goes and if this does not relieve some of my symptoms, I would appreciate someone who is knowledgeable about how I could possibly get CombiPatch from Canada. I have no idea how this works and I want to appreciate the information if someone can please help me. Thank you."

8 / 10
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7 Report
  • yogaf...
  • Taken for less than 1 month
  • August 16, 2021

CombiPatch (estradiol / norethindrone) "I am very disappointed with this product. After using 5 patches I developed a cyst on my right ovary and had to spend out of pocket for the ultrasound and vaginal camera test as my insurance would not pay. I started to haemorrhage very badly for about 4 hours and had severe cramping for weeks on end. I could not work in my office. Upon going to see an OBGYN, he said most likely this product caused this cyst as I was not using any other product at the time. I would highly recommend you NOT use this product. I wrote them a letter and asked for my out of pocket expenses including the repayment of the product, and I got NO RESPONSE. This is very unprofessional of them and just not ethically right. When this kind of negative side effect comes up, the pharmaceutical company needs to step up to the plate and be held responsible and do the right thing by responding to my request. DO NOT USE THIS PRODUCT AT ALL!!!!!!!!!!!"

1 / 10
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6 Report
  • CTrem...
  • Taken for less than 1 month
  • November 6, 2021

CombiPatch (estradiol / norethindrone) "This is in response to Loops. Yes I having something very similar. I went on this patch early October of this year to treat severe hot flashes as I am 51 years old. Last period as in August of 2017. November 4 of this year, 2021, I woke up in the middle of the night to blood. As in a full- blown menstrual cycle. A few days prior I had some light pink spotting but that was it. I will be seeing my doctor on the 16th to run some tests. She will check for various things; I'm very worried that this may be cancer. I keep hearing that when you bleed after menopause that's not a good sign. I've also read that this patch can cause bleeding, or it could be something like a reactivated fibroid. I've always had very heavy periods and don't miss those. Though the Combipatch has helped me out for the most part, I'm not sure if it's worth having a return of monthly cycles. At my age I really don't want to be dealing with periods anymore. Haven't been on this for even a month."

9 / 10
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5 Report
  • KarenS
  • Taken for 1 to 6 months
  • May 4, 2022

CombiPatch (estradiol / norethindrone) "I used CombiPatch for 5 months. After only two weeks of use, I experienced almost complete relief from my severe frequent hot flashes and insomnia. I did not have any problems with adhesion. Unfortunately I developed sensitivity to the adhesive and had to discontinue use."

8 / 10
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4 Report
  • Suano
  • Taken for 10 years or more
  • October 4, 2020

CombiPatch (estradiol / norethindrone) "I have used this drug for 13 years. The generic version made by Noven now uses a COMPLETELY INEFFECTIVE adhesive, making the use of their patch impossible as it does not adhere. There is no difference in my skin, I do not use lotions near the application. This is another example of shoddy technology. I will take my business elsewhere."

1 / 10
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6 Report
  • Kimmer
  • Taken for 1 to 6 months
  • August 9, 2021

CombiPatch (estradiol / norethindrone) "I was getting about 6 hot flashes per day and night sweats about 3 times per night to the point I was averaging 5 hours of sleep. CombiPatch fixed that but at a price. I have an itchy rash at the placement slight and gained 6 lbs within the first month on it. Not to mention it's $220/mo out of pocket after insurance (and I have good health insurance) and there's no generic. I tried 2 weeks of cutting the patch in half which didn't change the effectiveness but the rash and weight persist. I wanted desperately to like it but I'm hoping to switch to something else."

4 / 10
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5 Report
  • Curious
  • September 25, 2019

Mimvey (estradiol / norethindrone) "So this review is actually for mimvey. I just feel that norethindrone makes me weaker, have less energy and tied. I sleep 10 hours each night and its really annoying, because I can't wake up before 10 am - this really interferes with my goals in life and work situation. I will ask my obgyn to try a different type of progesterone. No hot flashes at all. No other side effects."

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6 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.