Eptinezumab and Nausea: What Users Say

• jan...
• Taken for 1 to 6 months
• December 9, 2022

Eptinezumab for Migraine Prevention "I have chronic daily migraines and have taken all three injectable CGRP medications: Emgality, Ajovy, and Aimovig. I sort of had my chronic daily headaches at a half-decent place, but this medicine was supposed to help in conjunction with the Botox and oral preventives I'm already on to take care of the last remaining symptoms. I had the infusion of 100 mg infused over half an hour. I was fine for about 4 hours, I want to say, and my cheeks and face got so red that my brown-colored blush didn't show. I felt extremely nauseated and like I was going to vomit, not to mention horribly physically sick and weak. It also gave me a migraine, and they worsened for about 10 days after. This is, for me anyways, one of the worst medications I have ever taken for the prevention of migraines, and the side effects are a lot worse it seems than advertised. I felt exhausted and gained weight as well, at least these effects are wearing off. I won't take a CGRP med ever again. If they work for you, great, but they're overrated."

• dov...
• Taken for 1 to 2 years
• November 6, 2021

Eptinezumab for Migraine Prevention "I have chronic migraines, some of which are hemiplegic, and I have tried so many drugs that didn't work - oral preventatives, Botox, Emgality, etc. Vyepti is the only drug that has helped me at all. Due to my migraine severity, I get the 300 mg dose once every three months. Vyepti brings my head pain from an 8 down to 5, 6, or 7, depending on my menstrual cycle timing. I have far less hemiplegic migraine aura, so I only have full-blown body weakness and trigeminal neuralgia-like face pain at the end of my three-month Vyepti cycle. Pros: less head pain, less face pain, less severe aura, lasts months, manageable short-lived side effects, less painful than self-injected CGRPs, doesn't upset the stomach. Cons: due to my migraine frequency, it takes 1-2 weeks to kick in after infusion, 2 weeks of allergy symptoms after infusion (runny nose, sneezing, itchy eyes, nose, throat, fatigue), nausea after 300 mg infusion (easily fixed with IV Zofran, does not occur with 100 mg dose)."

• Yog...
• Taken for 1 to 6 months
• February 19, 2022

For Migraine Prevention "I took my first dose in August 2021 and had no side effects. I took the Pfizer COVID vaccine on September 3, and I started to have nausea. I thought it was due to the vaccine, but a week before I was due for my second round of Vyepti, the nausea went away. I took the second dose, and the nausea returned. A week before the third dose was due, the nausea went away. Therefore, I decided to go back on Emgality. Within a few days of taking the Emgality, the nausea returned. Prior to August 2021, I took Emgality for nearly a year with no side effects. My doctor and I think that it is possible that the COVID vaccine and this class of medication do not mix. I have been on this class of medication since December 2019 whether it was Aimovig, Emgality, or Ajovy and did not have any nausea until I took the vaccine. I did have a significant amount of weight gain but thought it was from taking another medication. Recently, I have been reading that others have gained weight on Emgality, so I have to wonder."

• 123...
• Taken for 1 to 2 years
• May 20, 2025

Eptinezumab for Migraine Prevention "Works well! 100 mg dose: much less constipation than Aimovig high dose. But when I switched to 300 mg, the constipation was so much worse! Fewer/milder migraines, though, so it’s worth it! Without preventative medications, I can barely work part-time. With Vyepti, I can have a career. Fatigue on the day of infusion every time, and sometimes headaches. Shoulder pain for a week following infusion. Been having a lot more nausea, joint pain (knees, back, elbows, shoulders), anxiety, and my hair is so much greasier. Some of this could also be hormonal, as I’m 48 and female."