Eptinezumab and Constipation: What Users Say

• Yuc...
• Taken for 1 to 6 months
• August 30, 2021

For Migraine Prevention "NO positive reduction in daily migraines/headaches...no change whatsoever. I actually can not say ANYTHING good about these kinds of medicines. (CGRPs) I can only say DO NOT take them. I was told the only adverse side effect with Vyepti is a runny nose or stuffy nose. My Negatives - rapid heart rate, chest pain, insomnia, increased nausea/vomiting, bladder-kidney issues, extreme WEIGHT GAIN, hair loss, joint/muscle pain, constipation, fingers, thighs, genital blistering, fevers, mouth sores, dizziness & memory issues. I've had an ablation due to the cardiac issues. I actually told my Neuro 'I don't think Vyepti is working' & she said 'take another dose if you still don't find any relief, call back in a month & we will up the dose!' I had also tried Aimovig for over a year & then it just stopped working. She said 'that can't happen, something else caused it to stop working.' I have never received any relief with Vyepti but have seen crazy negative side effects."

• Har...
• Taken for 1 to 6 months
• July 6, 2022

For Migraine Prevention "It worked, it’s convenient, and I haven’t had the really bad constipation I got on Aimovig, but it doesn’t work nearly as well as Aimovig. I’ve also gotten a lot of increase in joint pain while on it. I think I’m going to switch back to Aimovig."

• 123...
• Taken for 1 to 2 years
• May 20, 2025

For Migraine Prevention "Works well! 100 mg dose: much less constipation than Aimovig high dose. But when I switched to 300 mg, the constipation was so much worse! Fewer/milder migraines, though, so it’s worth it! Without preventative medications, I can barely work part-time. With Vyepti, I can have a career. Fatigue on the day of infusion every time, and sometimes headaches. Shoulder pain for a week following infusion. Been having a lot more nausea, joint pain (knees, back, elbows, shoulders), anxiety, and my hair is so much greasier. Some of this could also be hormonal, as I’m 48 and female."