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Eptinezumab and Joint Pain: What Users Say

Brand names: Vyepti

Joint pain: mentioned by 6 users (11.8%)

Based on user experiences from 51 Eptinezumab reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 15.7%
joint pain 11.8%
dizziness 7.8%
fatigue 7.8%
migraine 7.8%
tiredness 7.8%
allergic reaction 5.9%
hair loss 5.9%
itching 5.9%
nausea 5.9%

Reviews for Eptinezumab

Commonly mentioned side effects
  • hel...
  • Taken for 1 to 6 months
  • January 17, 2023

For Migraine Prevention "My first infusion was a dream. No side effects and no head pain. The morning after the second infusion, I was in full anaphylaxis and have been ever since. I have also had an increase in joint pain and a problem with a palpating heart. I do not recommend. Prescribing physician stopped asking how my symptoms are. Feel very alone right now."

3 / 10
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42 Report
  • DrB...
  • Taken for 1 to 6 months
  • January 5, 2022

For Migraine Prevention "New neurologist started me on Aimovig 75 mg, then 150 mg, but no improvement of migraines or chronic daily headaches. Asked me to try Vyepti. Vyepti did not reduce migraine frequency, pain level, or chronic daily headaches, but resulted in debilitating fatigue and muscle/joint pain, confusion, concentration and memory issues, vertigo, periodic/recurrent cardiac arrhythmia, and hypertension. Most symptoms resolved over ~6 months, but periodic arrhythmia and hypertension remain. Although Vyepti may work well for some, it is not for all migraineurs."

1 / 10
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47 Report
  • Anonymous
  • Taken for less than 1 month
  • November 23, 2022

For Migraine Prevention "I just got my first dose of Vyepti 100 mg 3 weeks ago. It has helped me with my migraines, but it has caused me to have major pain in my joints to the point of keeping me up, crying all night. Trouble walking around far. I have been on every medication for migraines on the market. Nothing has helped until I tried this medication. The way I feel, I think I would rather have a migraine than deal with this pain. I have seizures, and I am allergic to almost every medication on the market. Plus, some medication can’t be taken with my seizure medication. This was my first, and I think my last!"

1 / 10
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32 Report

Frequently asked questions

  • kim...
  • Taken for 1 to 2 years
  • April 19, 2022

For Migraine Prevention "I have had chronic migraines for almost 15 years and learned to live and work in a chronic pain state of a level 5 or higher. For 21 years prior, I had the same employer and was out sick maybe 2 times. When my migraines worsened and I had a new career, I was out 1-2x weekly (at a pain level 8-9). It was embarrassing, and I was trying everything: Botox, Emgality, Ajovy, and Aimovig. Then my neurologist placed me on this, and I had a full hysterectomy. I am so lucky to not have extremely debilitating migraines anymore. I have anywhere from 5-7 a month (instead of 25) and at a pain level of 4 or less, which can mostly be treated with Aleve. Best thing ever. I am unaware of my dosage. My co-pay is $5. It is 1-1.5 hours out of my day every 3 months. My only complaint is I have increased sinus issues and joint pain. It reminds me of what I think fibromyalgia would feel like, but not all the time. I still wouldn't stop taking it."

9 / 10
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33 Report
  • Har...
  • Taken for 1 to 6 months
  • July 6, 2022

For Migraine Prevention "It worked, it’s convenient, and I haven’t had the really bad constipation I got on Aimovig, but it doesn’t work nearly as well as Aimovig. I’ve also gotten a lot of increase in joint pain while on it. I think I’m going to switch back to Aimovig."

6 / 10
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20 Report
  • Nov...
  • Taken for less than 1 month
  • September 18, 2024

For Migraine Prevention "I was diagnosed with migraine when I was 5, then, in adulthood, they became chronic. Over the past 3 months, I’ve had daily migraines, and no preventative or triptan has worked on this latest round of daily migraines. I received my first Vyepti infusion one week ago, and I have not had a single migraine since the infusion. So far, this medication is working well to prevent migraines, but for me, there has been a downside. Since receiving the infusion, I have had severe joint pain, and I am exhausted. I’m hoping that the joint pain and fatigue pass soon, but if they do not, I won’t be getting a second infusion. The joint pain is intense, and no OTC pain meds are working to relieve it."

5 / 10
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4 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.