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Diethylpropion and Headaches: What Users Say

Headaches: mentioned by 15 users (9.0%)

Based on user experiences from 166 Diethylpropion reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dry mouth 13.9%
headaches 9.0%
anxiety 8.4%
tremors 4.8%
constipation 3.6%
insomnia 3.6%
dizziness 2.4%
increased appetite 2.4%
sweating 2.4%
increased heart rate 1.8%

Reviews for Diethylpropion

Commonly mentioned side effects
  • Jen...
  • April 27, 2016

For Weight Loss (Obesity/Overweight) "I am completely satisfied with this medication. I had a few side effects the first 4 days (a bit jittery, headache, insomnia, constipation), but all but the constipation has passed. I have been on this for 3 weeks today and am down 11.4 pounds. I am thrilled with it as I had tried Phentermine and had terrible side effects and had to quit. I am on about a 900 to 1000 calorie daily diet, drinking lots more water and walking daily. It gives me a good energy...I want to be up and doing things, but not like hyperactivity. It's been a great experience so far."

10 / 10
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52 Report
  • LAL...
  • December 12, 2014

For Weight Loss (Obesity/Overweight) "I have been on this medication for 1 month, and it DOES take away hunger. I take my pill around 10 a.m. because I'm more of a late-night eater. I have had the headaches the first week taking the pills, but they have slightly gone away. This pill does make me feel a bit of the rapid heartbeat, but only for a bit. I did feel a bit of depression the first week taking it, and it's not like me at all, but as my body is getting used to it, that feeling went away. I have tried phentermine, and that gave me crazy energy. BUT I was still able to eat on it, it did not really take my hunger away like diethylpropion. I'm on the 75 mg ER, so it releases slower for the whole day. I exercise 5 days a week for 1 hr and 30 min, lost 12 lbs, and exercise and eat right."

8 / 10
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47 Report
  • Anonymous
  • Taken for less than 1 month
  • January 3, 2016

For Weight Loss (Obesity/Overweight) "After gaining around 70 pounds during the pregnancy of my daughter, regular diet and exercise just weren't cutting it. I've never taken diet pills before this, but in just 6 days, I've lost 7 1/2 pounds. I do get the dry mouth side effects, slight headaches, and funky vision here and there, but it's working wonders! I know the weight loss will slow down, but I'd like to lose another 40."

10 / 10
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38 Report

See also:

  • C N...
  • Taken for 1 to 6 months
  • October 22, 2015

For Weight Loss (Obesity/Overweight) "I have been on this medication a month, and I have lost 11 lbs. With the appropriate diet and exercise, this medication is wonderful. At first, it did give me the jitters and a mild headache, but after a few days, it's just fine. It controls my appetite, and I have to remind myself to eat a lot of the time. I also take Topamax at nighttime as part of my weight loss plan. I highly recommend this medication."

10 / 10
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37 Report
  • Lil...
  • Taken for less than 1 month
  • April 12, 2022

Diethylpropion for Weight Loss (Obesity/Overweight) "I have been on this for a month now, and I have lost 14 lb. I have a little headache in the evenings, but a little headache is worth it for me to lose this much weight. I am so happy with my progress, my goal is 50 lb. I hope that I can achieve it. I recommend this to help anyone."

10 / 10
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9 Report

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  • Hop...
  • Taken for less than 1 month
  • April 5, 2023

For Weight Loss (Obesity/Overweight) "Today is April 4, 2023, and I just started taking diethylpropion today. My first dosage of 25 mg was at 2 pm. About an hour later, I start getting a very mild headache, but it was not a bother to where I needed to take something for it, it could also be from my sinuses. I have noticed that my appetite has been minimal. So far, at 7:30 pm Central Time, I have had two protein drinks, a serving of tortilla chips, and some hummus, and I am not hungry. I'm hoping I can get my other two protein drinks in and another 32 oz of water down. So far, so good. I am a little nervous because I feel like I should eat something more, but I am not hungry. I pray this works for me without any side effects because nothing has worked for me since 2019 when I was 180 lbs, now I am 236.8 lbs, weight that I gained during COVID. As a plus-size woman who originally was weighing 265 lbs, 180 lbs was a weight I was comfortable with and looked good. When I dropped below 180 lbs, I looked sick. So my goal is 180 lbs."

8 / 10
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6 Report
  • FoZ...
  • Taken for less than 1 month
  • May 15, 2014

For Weight Loss (Obesity/Overweight) "I'm here to tell you all that this tablet does work. Due to suffering from anxiety attacks, I was put on these instead of phentermine, as these have fewer side effects. I was told to take 1 25 mg a day for three days and move on to two if I feel fine. I started these on Sunday 11/05/14, and the next day I weighed myself, I had actually put on 1/2 kilo, so I got disheartened. My weight at this time was 100.5 kilos. Yep, I know that's a lot, but I just weighed myself, and I'm now 98.5, yep, I lost 2 kilos in 5 days. Only side effect: headaches, but nothing else."

10 / 10
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21 Report
  • Det...
  • Taken for less than 1 month
  • September 22, 2021

For Weight Loss (Obesity/Overweight) "I have been taking diethylpropion 75 mg for 2 weeks and one day, and I have lost 14 pounds. It gives me lots of energy and cuts my cravings for snacks. I weighed 265 pounds when I started, and now I'm down to 251. My goal weight is 225 pounds. I would like to lose more, but I know that I can't take this med for a long period of time. In the beginning, I did have a headache, but the only problem I have is staying awake at night and dry mouth, but it is worth it because I love the weight loss."

10 / 10
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8 Report
  • foz...
  • Taken for less than 1 month
  • May 21, 2014

For Weight Loss (Obesity/Overweight) "Just started my second week. Starting weight was 100.5 kg. Weighed myself this morning, I'm 97.2 kg, so in 9 days lost about 6 lbs. Must say first two days had severe headaches, but by the 3rd day settled down. I tried every medicine, but nothing worked, but this seems to be shifting the weight."

10 / 10
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20 Report
  • Anonymous
  • Taken for 1 to 2 years
  • December 24, 2024

Diethylpropion for Weight Loss (Obesity/Overweight) "It's a slow burn for me. I'm shocked by those who claim to have lost significant weight in a short time. I've lost about 10 lbs in a year, which is not fast but the healthy way. I was about 40 lbs overweight. I've tried phentermine and herbal supplements, and I like this one the best. It doesn't make me feel weird, no headaches. What it does is help me not overeat, but I still very much have to do the work, i.e., self-help, coaching, and exercise. If I could stay more disciplined, I would lose weight much faster. Note: It took a while to find the right dosage and time, etc. I like the 75 mg ER, obviously for convenience versus taking 3 pills a day. I was taking it later in the day because my issues come at nighttime, but honestly, I find I do best taking it in the AM."

7 / 10
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  • sas...
  • Taken for less than 1 month
  • May 15, 2012

For Weight Loss (Obesity/Overweight) "I've been using the 75 mg of Tenuate for 2 days. I am not hungry at all, but I force myself to eat: breakfast is cottage cheese, fruit, and nuts in a bowl. Then, 1 bottle of water. I'm full until lunchtime 4 hrs. later. If I don't eat, I get a slight headache, so I make a half sandwich-tuna fish or turkey, lettuce, tomato, and lite mayo. I eat that with a small fruit: orange/grapes. I eat more cottage cheese, ground turkey burger for dinner, whole wheat bun, and veggies steamed and more water and juice. I'm so full when I finish, but I know it's working, so I make sure I'm full so I don't get tempted to go back in the kitchen after 6:00 pm. I exercise twice a day every day, low impact and cardio. I can see a difference already in my legs and arms. Love it."

10 / 10
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16 Report
  • Ano...
  • September 3, 2009

For Weight Loss (Obesity/Overweight) "The first month I was on diethylpropion, I had a little headache, but it goes away. I lost 11 lbs in the first month. The second month I was on this, I lost only 3 lbs, it's because you still do have to exercise. So I was off of it for 1 month and gained about 4 lbs because I went back to my old habits of overeating, and I didn't watch what I was eating. I think this pill will still work even if you get off of it, you just have to watch what you eat and count calories. I'm back on it again, and I have had some headaches, but it went away."

10 / 10
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15 Report
  • Anonymous
  • December 24, 2011

For Weight Loss (Obesity/Overweight) "Just started taking the 75 mg tablets daily, about 3 days ago, already have dropped 5 pounds, after just being on a normal diet of not eating as much and losing 85 pounds without the pill. I have found that it makes my cravings completely go away, and I have to make myself eat. I could go all day without eating if I wanted, but you can't lose weight unless you eat something. Only negative side effects were intense dry mouth, a little bit of a headache, which Tylenol can take care of, and my blood pressure skyrocketed a bit."

7 / 10
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12 Report
  • Anonymous
  • October 30, 2011

For Weight Loss (Obesity/Overweight) "I started diethylpropion four days ago. I now have hypothyroidism and have gained around 75 lbs since they did radiation for Graves' disease. The first two days, I was so tired and just wanted to sleep and had a headache. I have now gained 4 lbs and am walking daily. This is very discouraging, I am not a big eater, just have no metabolism since the thyroid treatment. I hope to have some good results soon and start losing instead of gaining."

5 / 10
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6 Report
  • Imi...
  • Taken for less than 1 month
  • April 19, 2025

For Weight Loss (Obesity/Overweight) "I started gaining weight about 5 years into my marriage and, although relatively tall at 6'4", I hit a peak of 290 lbs and I felt it on my body. I also have fatty liver and chronic pancreatitis, which unfortunately made me unable to take Ozempic and left me only with stimulant options. I started with Adipex 37.5 mg (Phentermine) BID and hated how it made me feel. I moved to Bontril PDM (Phendimetrazine) but felt high and edgy and my husband hated my behavior, so I stopped taking it. After about a month, I met with my weight loss specialist and requested to try Tenuate 25 mg (Diethylpropion) once daily to start. So far, I find it to be way more mild than the other two as well as similar in efficacy. It helps me not overeat and helps me exercise, but I don't feel stimmed out. There is a slight head change but not like Bontril PDM. I do get dry mouth, headaches, as well as an upset stomach, but I should acclimate soon. I am hoping this is the right one for me. Didrex is my final option."

8 / 10
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