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Diethylpropion Side Effects

Medically reviewed by Last updated on Aug 23, 2022.

Applies to diethylpropion: oral tablet, oral tablet extended release.

Serious side effects of Diethylpropion

Along with its needed effects, diethylpropion may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking diethylpropion:


  • Seeing, hearing, or feeling things that are not there
  • severe mental changes
  • shortness of breath

Incidence not known

  • Black, tarry stools
  • blurred vision
  • burning while urinating
  • chest pain
  • chills
  • convulsions
  • cough or hoarseness
  • decreased ability to exercise
  • depression
  • difficult or labored breathing
  • difficult or painful urination
  • dizziness
  • fainting
  • false or unusual sense of well-being
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fear or nervousness
  • fever with or without chills
  • frequent urination
  • general feeling of tiredness or weakness
  • headache
  • inability to speak
  • increased volume of pale, dilute urine
  • lower back or side pain
  • nosebleeds
  • numbness or tingling in the face, arms, or legs
  • restlessness
  • severe or sudden headache
  • shakiness in the legs, arms, hands, or feet
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the feet or lower legs
  • swollen glands
  • temporary blindness
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • trouble with breathing
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vision problems
  • weakness in the arm or leg on one side of the body, sudden and severe
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking diethylpropion:

Symptoms of overdose

  • Abdominal or stomach cramps
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • change in consciousness
  • confusion
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • increased sensitivity of the eyes to light
  • loss of consciousness
  • nausea
  • overactive reflexes
  • panic
  • physical attempt to injure
  • restlessness
  • sweating
  • violent actions
  • vomiting

Other side effects of Diethylpropion

Some side effects of diethylpropion may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Abdominal or stomach discomfort
  • bruising
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dry mouth
  • general feeling of discomfort or illness
  • hair loss
  • headache
  • hives or welts
  • indigestion
  • itching
  • large, flat, blue, or purplish patches in the skin
  • loss of appetite
  • muscle pain
  • passing of gas
  • redness of the skin
  • skin rash
  • sleeplessness
  • stomach fullness or discomfort
  • trouble sleeping
  • unable to sleep
  • unpleasant taste

For Healthcare Professionals

Applies to diethylpropion: oral tablet, oral tablet extended release.


Very rare (less than 0.01%): Valvulopathy

Frequency not reported: Precordial pain, arrhythmia (including ventricular), ECG changes, tachycardia, blood pressure elevation, palpitation, valvular heart disease[Ref]


Rare (less than 0.1%): Pulmonary hypertension

Frequency not reported: Dyspnea[Ref]


Rare (less than 0.1%): Psychotic episodes

Frequency not reported: Insomnia, anxiety, euphoria, depression, dysphoria, tremor[Ref]

Nervous system

Frequency not reported: Convulsive episodes, dyskinesia, overstimulation, nervousness, restlessness, dizziness, jitteriness, somnolence, headache, cerebrovascular accident[Ref]


Frequency not reported: Urticaria, rash, ecchymosis, erythema, hair loss, increased sweating[Ref]


Frequency not reported: Impotence, libido changes, gynecomastia, menstrual upset[Ref]


Frequency not reported: Vomiting, diarrhea, abdominal discomfort, dry mouth, unpleasant taste, nausea, constipation, other GI disturbances[Ref]


Frequency not reported: Dysuria, polyuria[Ref]


Frequency not reported: Bone marrow depression, agranulocytosis, leukopenia[Ref]


Frequency not reported: Muscle pain[Ref]


Frequency not reported: Blurred vision, mydriasis[Ref]


Frequency not reported: Malaise[Ref]


1. "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.