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Enskyce and Mood Swings: What Users Say

Mood swings: mentioned by 29 users (34.9%)

Based on user experiences from 83 Enskyce reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

mood swings 34.9%
nausea 20.5%
headaches 16.9%
bleeding 14.5%
bloating 13.3%
cramps 13.3%
depression 13.3%
anxiety 12.0%
spotting 12.0%
acne 10.8%

Reviews for Enskyce

Commonly mentioned side effects
  • Bik...
  • March 6, 2021

For Birth Control "Should be illegal! Constant bleeding, extreme bloating (look 6 months pregnant), severe mood swings from angry to hysterical, uncontrollably sobbing for days, severe depression, breakthrough bleeding almost the entire cycle, insomnia for days, anxiety and panic attacks, swelling, massive weight gain (8 lbs) despite eating 1,200 calories and biking every day, horrible fatigue! Tried multiple times and gave up after the fourth month."

1 / 10
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26 Report
  • iFr...
  • Taken for 1 to 6 months
  • July 6, 2014

"I switched to Enskyce from Reclipsen for cost-effectiveness and felt different almost immediately. After a few weeks, I noticed that my emotions were considerably more inconsistent. Small things that wouldn't normally bother me started to make me extremely upset, and although I realized that I shouldn't have been upset at the time, I felt like I couldn't pull myself out of being emotional. I didn't pay any mind to it because I thought some outside things could've been stressing me out, but it got to the point where I'd be having emotional breakdowns almost weekly and about normally insignificant things. Periods were thicker and more painful. Effective as a contraceptive, but the side effects were a deal-breaker for me."

6 / 10
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31 Report
  • emi...
  • Taken for 1 to 6 months
  • January 22, 2022

For Birth Control "For the last 3 weeks, I have been an emotional mess, with my moods swinging from furious to extremely sad to overwhelmingly depressed. I thought maybe it was just me, but after reading these reviews, I am so relieved to know that it is a side effect."

3 / 10
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12 Report
  • Bea...
  • Taken for 2 to 5 years
  • September 30, 2020

For Birth Control "I went on this birth control about 2 years ago, and I feel like a different person. I don't know why I didn't switch off of it sooner. Made me an emotional wreck, affected my relationship, and worsened my acne. Steer clear from this."

2 / 10
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15 Report
  • mom...
  • Taken for less than 1 month
  • January 26, 2022

For Birth Control "HORRIBLE. My pharmacy changed the brand of my birth control three weeks ago, and I have been having severe mood swings, panic attacks, depression, and anxiety. Not to mention the lowest sex drive I have ever had, and I'm only 26. The last three weeks have been a nightmare. I have a toddler and a 4-month-old, and quarantining with two kids under two for 10 days while being on these pills caused some VERY bad moments. I threw these out immediately once I figured out what was causing these depressive episodes. Just sharing my experience so that others don't go through what I go through. You are NOT going crazy. These pills are making you crazy. Trust me."

1 / 10
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10 Report

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  • Dan...
  • Taken for 1 to 6 months
  • January 31, 2021

For Birth Control "I want to share because it seems like most people only ever post reviews if their experience was negative. This Enskyce birth control has been wonderful for me. After having my Paragard taken out, I needed to get back on a pill. I tried Ortho Tri-Cyclen Lo and Yaz, both of which made me feel like I was gaining weight! Finally, my Dr. put me on this brand, and I have had NO problems. I had minor blemishes (unnoticeable to everyone else) the first month. My period is light, and I've had no emotional issues. While I've only been on this pill for three months, I'm really happy with this brand. With the others, I could feel negative effects very quickly."

10 / 10
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10 Report
  • Tar...
  • Taken for less than 1 month
  • September 10, 2020

For Birth Control "This Enskyce is the worst birth control pill I’ve ever taken. I took it for 3 weeks and am switching back to Marlisa, which I was on for over a year. Just within the few weeks, I have been an emotional MESS. I’ve never felt mood swings this intense or started crying because of simple little things that should definitely not be making me cry my eyes out! The skin on my face has also dried out so much that it seems like normal moisturizer has done nothing. I’ve lost basically all of my appetite and need to force myself to eat throughout the day because I never feel hungry anymore. Sex drive is also much lower, almost to the point that I have none."

1 / 10
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8 Report
  • Tar...
  • Taken for less than 1 month
  • September 10, 2020

For Birth Control "This Enskyce is the worst birth control pill I’ve ever taken. I took it for 3 weeks and am switching back to Marlisa, which I was on for over a year. Just within the few weeks, I have been an emotional MESS. I’ve never felt mood swings this intense or started crying because of simple little things that should definitely not be making me cry my eyes out! The skin on my face has also dried out so much that it seems like normal moisturizer has done nothing. I’ve lost basically all of my appetite and need to force myself to eat throughout the day because I never feel hungry anymore. Sex drive is also much lower, almost to the point that I have none."

1 / 10
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8 Report
  • JSa...
  • Taken for 1 to 6 months
  • January 28, 2020

For Birth Control "STAY AWAY! I’ve been on Enskyce for two months and have decided to call it quits. I have had three full periods while on active pills per my IVF doctor. Spotting if I’m not actively bleeding, migraines every day that I cannot get control of, and major mood swings, mostly the urge to cry. I’ve also experienced weight gain and cystic acne. I don’t know what I’ll be on next, but I’ll never take Enskyce again. It has controlled my everyday life."

2 / 10
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7 Report
  • NJa...
  • Taken for less than 1 month
  • September 10, 2019

For Birth Control "Enskyce honestly is the worst birth control I've had. I have had depression on a previous pill (Cyred) before, but that was always just two days before my period. This one gives me really bad mood swings, going from being fine to being super angry or completely depressed to the point of crying. This is all within the first two weeks of taking the pills. I've also started getting really bad headaches about an hour after taking the pill and have felt really fatigued. I have never experienced this many side effects within the first month of taking a birth control pill. I've been on Cyred and Reclipsen. Reclipsen was the best for me, but they changed it at the pharmacy because 'they're the same thing.' Obviously not."

1 / 10
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7 Report
  • Awf...
  • Taken for 1 to 6 months
  • September 4, 2022

For Birth Control "I’ve tried this brand twice, and each time just gets worse. First time trying, I was just nauseous and had no energy almost all day. Just started it again, and it’s awful! Mood swings like crazy, random crying out of nowhere, and feeling dizzy. Shouldn’t even be available to anyone."

1 / 10
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4 Report
  • Lex...
  • Taken for less than 1 month
  • August 21, 2018

For Birth Control "This pill is absolutely awful. Took it to help with my PMS symptoms, and nothing has changed, if anything, it’s only gotten worse. On top of that, I have experienced extreme mood swings, worse than anything I’ve known in myself. I am not the usual person I am. I am angered easily, I have severe depression. I am dazed and drowsy. Enskyce has done more harm than good. Would strongly recommend avoiding it!"

1 / 10
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7 Report
  • KDa...
  • May 14, 2019

For Birth Control "I am giving this Enskyce pill a 3 in terms of 'effectiveness' because it worked to prevent pregnancy, but as others have mentioned, the emotional changes are not worth it. When I started with my pharmacy a year ago, they switched the medication without notice. Like others, I assumed the generic version would be the same as I am usually not picky. This pill made me feel extremely irritable, and it usually takes me a lot to get worked up. I didn't realize that it was due to the pill switch until I forgot to refill with Caremark and had to pay for a pack of Apri at my local pharmacy. I had 0 issues with my mood when I switched back, and then as soon as I was back on the Enskyce, my irritability started back up again. I'm not sure what the difference is, but it is different. I was searching for a reason as to why I could possibly be irritable since there were no actual reasons for it - adding my review to this pile because reading others' experiences helped me not feel so crazy for demanding my Apri back!"

3 / 10
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6 Report
  • yol...
  • Taken for 1 to 6 months
  • August 6, 2018

For Birth Control "Worse, worse pill ever!! I was on Isibloom, then insurance changed to Enskyce. It has been 7 weeks on it, and I'm spotting every day, which is horrible for sex life; I'm moody and emotional, which is not like me, and I gained 6 lbs! I'm finishing this pack and requesting my old pill, even if I have to pay more! This is not worth it, and FYI, I take it at the same exact time daily. Oh, and the headaches are daily!! Run from this brand, please."

1 / 10
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6 Report
  • Ano...
  • Taken for 1 to 6 months
  • March 9, 2018

For Birth Control "I never give reviews, but this is the worst birth control pill I’ve been on besides TriNessa. This one is absolutely worse, though. This specific one gave me horrible headaches for the first two packs and made me extremely emotional. I’m a very sweet person, and it takes a lot to get me angry. Now I get so annoyed and angry extremely easily. I shouldn’t have the angry feelings I have and did not have them before I started this prescription. Do not recommend at all!"

2 / 10
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6 Report
  • Fed...
  • September 21, 2020

For Birth Control "I’ve been on Enskyce for almost 2 years now. I have experienced increasingly worse PMS/periods, random spotting or early periods, mood swings, unstable angry/anxious/depressive episodes, and the nausea seems to be every day now to where I just don’t eat until I’m sick for calories. It’s the worst. Eating has no enjoyment anymore. It took me so long to figure out that Enskyce was the cause of my unpredictable moods and horrible stomach pain/PMS. I’ve experienced anxiety/depression beforehand, but I assumed I was just getting worse and worse. I only came across this page while searching for a therapist when I realized my stomach was hurting again 2-5 hours after taking the BC. I then searched the side effects and kept reading the symptoms other women were having. 1/10, and the 1 is because I haven’t gained weight."

1 / 10
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4 Report
  • Sop...
  • October 14, 2017

For Birth Control "Do NOT take this medication. I am 22 years old and have been on the pill since 16. I was having intense menstrual bleeding, so my doctor prescribed me a higher dose and ended up giving me this brand. It did not help my cramps whatsoever, and it made me very emotional. I lost all of my sex drive and became very dry down there. The most scary part is yet to come... A month and a half into it, I became EXTREMELY dizzy and lightheaded. I decided to finish up the month, then get off of it. However, 2 weeks off of it, and I am still extremely dizzy and lightheaded. I have gotten every blood test, and nothing comes up. I have seen that several other women experienced pulmonary embolism in the lungs and will be getting this checked out. DO NOT USE!"

1 / 10
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4 Report
  • Nic...
  • Taken for 1 to 2 years
  • May 20, 2019

For Birth Control "I got on birth control because my periods were very heavy. I’m giving the Enskyce pill a 7 because it helped clear acne, other than the occasional breakout, and it has done a good job at preventing pregnancy, however, it barely helped make my period lighter, and it has changed my mood drastically. I’ve noticed at the end of each pack I get very depressed for a few days for no reason, and then it goes away. It just messes with me emotionally."

7 / 10
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2 Report
  • Anonymous
  • Taken for less than 1 month
  • February 16, 2022

"Same as a previous user mentioned, I only had to take this for 3 weeks prior to IVF, but whoah! In the first 3 days, I was emotional, irritated, and nauseated. It was horrible and not me. It had crippled my daily life. I noticed the onset of nausea and mood swings within 4-6 hours of taking the medication. I decided to take it before bed and found that most side effects have calmed down. I am on day 11 now, feeling much more like myself with a better appetite, but wow, Enskyce has horrible side effects during initial use. I also have been spotting the last two days, assuming again this is Enskyce, no weight gain or additional symptoms."

1 / 10
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1 Report
  • Anonymous
  • Taken for less than 1 month
  • February 16, 2022

"Same as a previous user mentioned, I only had to take this for 3 weeks prior to IVF, but whoah! In the first 3 days, I was emotional, irritated, and nauseated. It was horrible and not me. It had crippled my daily life. I noticed the onset of nausea and mood swings within 4-6 hours of taking the medication. I decided to take it before bed and found that most side effects have calmed down. I am on day 11 now, feeling much more like myself with a better appetite, but wow, Enskyce has horrible side effects during initial use. I also have been spotting the last two days, assuming again this is Enskyce, no weight gain or additional symptoms."

1 / 10
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1 Report
  • EnG...
  • Taken for 1 to 2 years
  • January 31, 2021

For Birth Control "This is my second birth control I've tried, and compared to the first one (whose name I forgot), this one was amazing for me. My acne on my back got better and wasn't a concern with acne on my face. I was more susceptible to being emotional, but that was at night, where most minds are typically active. I didn't have any major negative side effects either. Cycle started and ended at the same time and length consistently. Sex drive wasn't affected. Would get a cramp once in a blue moon. I suddenly got switched over to Isibloom when I went to pick up my prescription. So I'm going to give it a go and see how it goes for a couple of months and switch back if needed."

9 / 10
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1 Report
  • mol...
  • Taken for 1 to 6 months
  • June 14, 2021

For Birth Control "I just finished my first month of this. I previously was on Nortrel 7/7/7 and have tried the ring. This has been the most problematic off the bat. Although my acne seems to be getting better, I have bled every day since starting the pack. It seems to be more than spotting though, it's a flow similar to the middle of my period. Also, when I started my placebo pills, my “period” has been more heavy than any I've had in my life. In the first week, I experienced nausea, extreme mood swings, and depression. My symptoms have not been consistent with any of the other times I’ve been on birth control, hopefully, they get better over the next 2 months, or I’m asking for a different birth control."

6 / 10
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1 Report
  • Mol...
  • Taken for 1 to 6 months
  • December 20, 2020

For Birth Control "Terrible, terrible, terrible. Other than it working, it’s terrible. I've NEVER had an issue with acne until starting this BC. When I first started taking it, I thought that the acne and extreme fatigue were because I switched birth control methods and my body was adjusting. Three months in and acne worsened, and I’m still tired all the time. I’m more emotional and sensitive towards things, where I’m constantly putting myself down. Come Monday, I’m calling my doctor to switch me to a different brand. I just can’t anymore with this birth control brand."

1 / 10
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1 Report
  • Ris...
  • Taken for 1 to 6 months
  • July 20, 2020

"It’s a shame that Enskyce was my first experience with birth control. It is terrible. I had horrible mood swings and was really depressed. My period was heavier and my cramps were unbearable (worse than when I was off birth control). I also experienced breakthrough bleeding in my 4th month of the pill. The only positive was no weight gain. Do not take this pill for your own sake!!!"

2 / 10
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1 Report
  • Ano...
  • Taken for 6 months to 1 year
  • January 22, 2023

For Birth Control "I have been on Enskyce for 6 months. Before Enskyce, I was on Azurette, which is the same hormone combo but a little lower on the estrogen. I switched to the higher estrogen pill, Enskyce, because I kept spotting terribly on Azurette. The spotting did get better on Enskyce, although it took months. So far, Enskyce is the best birth control I have ever been on - others I have tried have been Ortho Tricyclen Lo (neither good nor bad, but didn't help my heavy period at all), Norethindrone minipill (awful, terrible side effects, constant heavy bleeding), and Azurette, as I stated earlier. So far, Enskyce is the clear winner. I did have emotional side effects for the first month, however - I was really cranky and over-sensitive. Just really impatient and easily annoyed. I became a real jerk, and it was very out of character for me. It went away after a month. My period is significantly lightened by Enskyce, which was my goal in taking BC as my natural period is horrendously heavy."

9 / 10
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0 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.