Dalfampridine and Constipation: What Users Say

• Mom...
• April 4, 2020

For Multiple Sclerosis "I was diagnosed with RRMS in 2014, and the main sign that sent me to the doctor was my weakness in my legs. I recently found an amazing neurologist who finally agreed that I did have loss of feeling and weakness in my legs. He put me on Ampyra for four weeks to see if it made a difference for me. Well, today it has been 30 hours since I have had my last dose, and while trying to shop this morning, I almost cried. The difference was amazing for me. While I was on it, I didn't have to use the handrail and push on my legs to walk up the stairs. It was so much easier for me to get up from sitting, get in and out of my car, and my balance improved so much. Hopefully, I can get ahold of my doctor to get back on this soon! He told me to wait four weeks, but I don't think I can wait that long. It's definitely worth trying if you have leg problems! The only side effect I had was constipation, but I changed my diet and eventually had no issues."

• K-m...
• Taken for 2 to 5 years
• June 8, 2014

For Multiple Sclerosis "Started taking 3-4 years ago in early 50s while transitioning from RR into SP. Early on, saw subtle improvement with only mild constipation, but was unable to go without AFO. Past year in SP, balance and gait worsened, where use AFO and cane full-time. Decided a month ago to stop taking. Balance much better. Gait seems unaffected. Living with SP is definitely different from RR."

• Jar...
• Taken for 2 to 5 years
• May 11, 2017

For Multiple Sclerosis "This is a missing side effect that should've been noted in the prescription information! For the first two years this medication came out, I continued to use it along with my disease management drug. I was taking Tecfidera. These two medications combined drastically slow down your lower intestinal. Ampyra lists constipation as a minor, less common side effect. After some research with my doctor, he researched the medications in medical journals and the chemical compounds, and he thought the two should not be taken together for this particular reason."

• Anonymous
• April 1, 2012

For Multiple Sclerosis "Caused constipation, but the medicine has definitely increased the quality of life. I have been on it for 6 months and it is as good today as that first couple weeks."