Cyproheptadine and Headaches: What Users Say

• Anonymous
• January 5, 2009

Cyproheptadine for Cluster Headaches "This drug is great for cluster headaches. I have spoken with over 150 cluster headache sufferers. I took one tablet each night for the first week, and it has ended the cycle of headaches. The first night after taking one, you will still have a headache, but it will last about one half hour or so. On the second night, according to the people I have spoken with, 145 out of the 150 had the cycle of headaches ended. The remaining 5 on the 3rd and 4th day. Keep in mind you must take this medicine for up to 2 months to make sure the cycle is contained. The only way to know is to judge how you feel. Your doctor cannot do this for you. I have been having these headaches for 18 years. PLEASE TRY."

• Anonymous
• April 9, 2012

Cyproheptadine for Migraine "I was pregnant, I had to stop taking Relpax (at 2 x a month) for migraines, and I made notes and found I had horrible pain 20 out of 30 days in the month. For 2 months, I suffered, and my OB referred me to my neuro, who referred me to my OB, and no one would help me. A new neuro put me on Periactin 4 mg once a day. I started it on - I think day 2 of what usually is a 3-day migraine, and it stopped. I had only a faint sensation of a headache."

• Ris...
• Taken for 2 to 5 years
• November 27, 2019

For Anorexia "Took Periactin once a day, as it made me very drowsy and heavy-headed. Although my appetite picked up a lot and over a year I put on about 10 kgs, which I wanted, it was the worst decision to take these tablets as it caused severe dryness in my eyes. This has led to terrible eye pain day and night. Sadly, I didn't make the link between the tablets and the pain until too late, but I have now stopped taking them. They probably work for some without side effects, but not for me, unfortunately."

• Sco...
• January 5, 2019

For Anorexia "I've always struggled with my weight. I'm 30 years old with 2 boys, and my weight rocketed with both pregnancies and went right back down again. lol I've tried quite a few things, but nothing really helped. I do remember going to a Chinese herbal store 3 years ago and was given a powder mixture to mix with water and drink twice a day. It works, but I'm not good with drinking large quantities. Fast forward to today. I'm currently 5'6, weighing 153 lbs. I hate seeing what I see in the mirror: skinny arms, collarbone poking out, my breasts are literally nonexistent. It's sad! So, I went to my GP on 3/1/2019 and asked for Periactin. She was happy to prescribe it to me. It's been two days I've been taking these now, I take 3 a day, and they make me so hungry. I've also noticed I haven't been getting the sleepiness or headaches some say they have experienced within the first 3 days of taking them. I will be back to update after a week or 2 to see if I've gained any weight since."

• Red...
• Taken for less than 1 month
• August 4, 2016

For Migraine "It got prescribed this when I started getting horrible headaches almost daily. I was told to take it two times daily, once in the morning and once at night. It gave me more headaches, at least an aura without pain. I had increased blind spots in my vision, as well as it made me extremely tired. Stopped taking it."

• Sar...
• December 14, 2017

For Anorexia "I tried this on a whim, after reading a lot of reviews. I was a little nervous, as my doctors have never heard of it. Still, I took the chance because I was desperate, and I've gained 15 pounds in 3 weeks! I'm still in shock. My stomach somehow turned into a bottomless pit. I will say though, I kept falling asleep for the first 3 days. Like, deeeeeep sleep. And I had the worst headaches of my life. BUT, it subsided after about 3 days. I still get a little drowsy and disoriented at times, but I don't take it as often now. I started with 3 doses of 4 mg/day, and now I take it once before bed."

• Ash...
• Taken for 2 to 5 years
• February 7, 2015

For Migraine "I have been taking this for around three years now, and I found that for the first year I was headache-free. On my second year, I was occasionally getting headaches like 2 or 3 a month. Then, after my third year of being on the medicine, it seemed as though I was taking nothing to help with migraines. I have now been getting up to 10 migraines at different times per day. I went to see my neurologist, and he said I'm having uncontrolled migraines, and he put me on Topamax, so I guess I will see how that goes."