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Belimumab and Depression: What Users Say

Brand names: Benlysta

Depression: mentioned by 3 users (4.5%)

Based on user experiences from 67 Belimumab reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

fatigue 25.4%
pain 16.4%
joint pain 13.4%
headaches 11.9%
brain fog 9.0%
nausea 6.0%
swelling 6.0%
allergic reaction 4.5%
depression 4.5%
dizziness 4.5%

Reviews for Belimumab

  • Mtb...
  • Taken for 1 to 2 years
  • May 30, 2020

For Lupus "I have been on Benlysta for two years and it was helping my Lupus. BUT, recently, it started to give me depression, anxiety, and I thought about ending my life. I ended up in a psychiatric hospital last week. After that, I started looking into my medications. If you have any history of any mental illness, please be careful!"

1 / 10
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103 Report
  • Lcp...
  • Taken for 2 to 5 years
  • May 29, 2023

For Lupus "I got Benlysta via infusions approximately 8 years ago and loved it. RA became aggressor and SLE was recently deactivated. Granted, I was not of adult age getting infusions and now have my own life and child, so opted for injections this time. This literally feels like poison going in. I’ve had over 10 years of being pricked and injected but thought it was due to my body’s underlying symptoms exaggerating it. Just did injection 5 and I hate it. Hoping it’ll help again and not emphasize depression. I would recommend because I remember this being one of my favorite things to get when doing infusions because I’d take a nap and wake up brand new. Pending opinion now."

8 / 10
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6 Report
  • Gol...
  • Taken for 1 to 6 months
  • June 18, 2025

For Lupus "Been on the injections for 6 weeks. I have had blisters forming on my scalp, body aches, pain on the left side of my head... eye, cheekbone, ear, and lymph node, irritability, depression, and severe fatigue."

3 / 10
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0 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.