Belimumab Dosage

Medically reviewed on August 22, 2018.

Usual Adult Dose for Systemic Lupus Erythematosus

10 mg/kg IV at 2-week intervals for the first 3 doses and at 4-week intervals thereafter.

Comments:
-Infuse over a 1-hour period.
-Consider premedication including an antihistamine, with or without an antipyretic, before the infusion.

Use: Treatment of adult patients with active, autoantibody-positive, systemic lupus erythematosus (SLE) who are receiving standard therapy.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Do not administer intravenous push or bolus.

Storage requirements:
-Refrigerate, protect from light.
-Do not freeze.
-Avoid exposure to heat.
-The total time from reconstitution to completion of infusion should not exceed 8 hours
-After reconstitution, if not used immediately, protect from direct sunlight, and refrigerate.
-After final dilution in sodium chloride 0.9% solution, may store refrigerated or at room temperature.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility:
-Not compatible with 5% dextrose
-Do not infuse concomitantly in the same intravenous line with other agents.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer