Imuran and Nausea: What Users Say

• Anonymous
• February 2, 2012

For Autoimmune Hepatitis "I have chronic autoimmune hepatitis and have been taking Imuran for four years. It has prevented further flare-ups (which I have taken as much as a year to recover from). It enables me to live my life feeling well with mild side effects (some nausea)."

• Mar...
• Taken for 6 months to 1 year
• December 24, 2018

For Lupus "I've been on Imuran for 6 months, and it hasn't helped at all. In fact, I'm sicker now on it. The biggest side effects for me are loss of appetite, nausea, and diarrhea. The diarrhea is horrible. I go at least 10 times a day, and nothing helps. I'm exhausted from being so dehydrated and malnourished. When I see my rheumatologist in a week, I'm begging him to try anything else but Imuran. I can't handle it anymore."

• Rub...
• Taken for less than 1 month
• January 14, 2020

For Lupus "So, I’m a few days on Imuran for SLE. The first day was okay for me, but then the days after that, I started getting headaches, feeling nausea, and having on-and-off diarrhea. I also don’t feel hungry nor full. Just average, basically, all the time. I also noticed I started losing some weight. Not sure what will happen in the future. Just hoping for the best."

• chr...
• April 29, 2019

For Inflammatory Bowel Disease "Shortly after commencing Imuran at a low dose (50 mg/day), I developed a severe and persistent headache and also felt very tired and listless. One week later, everything got a lot worse: within 24 hours of commencing the higher dosage (100 mg/day), I began to feel extremely nauseous, and about an hour later, non-stop vomiting commenced. I couldn't even swallow a mouthful of water without bringing it up almost immediately. That night, all the joints in my body began to swell up and become very painful. By 3 a.m., I could barely walk, and by 7 a.m., my husband had to call in emergency services: my BP had dropped to 56/40, so I was immediately taken to the hospital, where I was treated with copious amounts of IV fluids, antiemetics, and high doses of corticosteroids. Over the next few days, I very gradually began to improve and was discharged from the hospital 6 days later, but it took many weeks before I was anywhere near back to normal."

• Anonymous
• October 3, 2016

For Crohn's Disease, Maintenance "I was only diagnosed in May and have been on Uceris and Imuran. Currently taking Imuran 50 mg, and now that I have been on it for a few months, I have been getting nausea every time I take it. Zofran does not even help, they are talking about doing the infusion now. I'm just so tired of being sick. Did this happen to anyone else?"

• Nic...
• Taken for 1 to 6 months
• January 26, 2022

For Lupus "I took it for a month. The first week it made me nauseous, which I just took promethazine to help with, but it didn't take the feeling completely away. I wasn't really eating, and the diarrhea started at 2 weeks. By the 4th week, I felt horrible! Headache, weakness, stomach pain, vomiting, and diarrhea from Sunday to Friday. It was then I knew, although effective for some, and I'd really hoped it would help after seeing so many great reviews, but I requested something else."

• Cam...
• Taken for less than 1 month
• January 6, 2022

For Rheumatoid Arthritis "I've been taking Imuran for 2 weeks now to treat my inflammatory arthritis, since no other drug seemed to help. I haven't noticed any improvement yet, but the nausea is unbearable. I'm not able to eat anything, and I'm constantly hungry. Reminds me of my pregnancy morning sickness, though it's not as bad as methotrexate was. I've already lost a bit of weight due to this. Yesterday, I started taking anti-nausea medication to be able to cope. I hope the side effects end soon and the drug helps treat my symptoms."

• Nau...
• Taken for 6 months to 1 year
• February 26, 2017

For Ulcerative Colitis "With Imuran, I had no quality of life. Daily fatigue and nausea/vomiting. Things are better on Entyvio."