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Epiduo and Pain: What Users Say (Page 2)

Reviews for Epiduo

Commonly mentioned side effects
  • Fro...
  • Taken for less than 1 month
  • September 29, 2021

For Acne "I got prescribed Epiduo one week ago, and I've been putting it on two times since then. And oh my god, it's so painful. My skin is red, and it is so dry I can barely open my mouth. I'm having to constantly wash my face with water because the moisturizer I'm using is barely working for more than ten minutes. I'm thinking of quitting the medication every second, but reading all of your comments really inspires and motivates me to keep fighting."

5 / 10
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  • Anonymous
  • June 17, 2012

For Acne "My skin peeled severely for about 3 weeks, and I went through a lot of itching and burning. The acne cream is meant for small pimples, not if you have many breakouts all over your face. The process takes a long time, 3 months, and your face hurts almost every day. But once those 3 months pass, your face looks great."

4 / 10
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  • Mrs...
  • Taken for 1 to 6 months
  • June 2, 2015

For Acne "Unfortunately, this medication just didn't work for me. First off, while I understood from the many reviews I read that there may be some stinging, the pain I experienced was excruciating and didn't dissipate with time. The pain actually turned out to be an allergic reaction to benzoyl peroxide, so don't disregard it if you continue to experience pain despite careful, staggered application over a couple of months. Secondly, it simply didn't clear my acne, but it did temporarily smooth out my frown lines and fine lines on my forehead, which was an unexpected bonus. Hope it works for you, it was simply the wrong product for me (Aczone turned out to do the trick)!"

3 / 10
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  • Des...
  • December 28, 2015

For Acne "I started about a month ago, it seems to be taking a long while to start showing any difference. If anything, my acne is getting worse, but in new spots. Also, I can't use it every night as directed because the dryness and burning are too much to handle. Literally tearing up from pain. I'll update again if it starts doing its job :("

3 / 10
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  • Mor...
  • August 27, 2015

For Acne "This summer, I decided that I was finally going to begin acne treatment for my face. Surprisingly, being in the sun helped a lot, and then my doctor recommended Epiduo. I was excited to finally have clear skin. Then I tried it out for two weeks. I noticed my skin getting progressively worse. Then, after a while, I began feeling an odd burning sensation. The next morning, I woke up to blotchy, painful, burning skin. Basically, nothing could soothe it, and I started school later that week. The burning was terrible, and makeup couldn't cover it. I've tried various moisturizers, but none helped. I was stuck with skin that was a lot worse than before I started, and a blotchy, burning, bright red spotty face. I don't recommend trying this product."

1 / 10
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  • Al ...
  • Taken for 1 to 6 months
  • August 11, 2017

For Acne "Epiduo has worked for me tremendously. I was having cystic acne. It was getting bad, I had a reoccurring spot above my lip. Extremely painful. The Epiduo gel exposed the core of the infection, brought it to the surface, dried, and cleared and healed nicely. Hasn't been back since. 1. This medicine brought all reoccurring pimples to the surface, drained... sore, gross, I know. Then it dried it out, minimized the site like overnight. And I believe it helped it heal with way less scarring than without intervention. 2. It dries out skin. Sloughs off all dead skin. New pimple-free skin emerged. Years of intervention and this worked! It reveals brand new skin. I'm sure it helps with scarring and wrinkles."

10 / 10
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  • Bes...
  • Taken for 1 to 6 months
  • March 28, 2023

For Acne "My daughter has used this product, and her skin is burnt. She’s 14, and her skin is stinging and hurting her. I wouldn’t recommend buying it because it hasn’t worked, and she has used it for ages, but now it's stopped. I know it’s supposed to sting, but not this bad. It’s awful seeing my daughter in pain! I would not recommend it."

1 / 10
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  • Anonymous
  • January 15, 2018

For Acne "I love this product! It really works for me! I wish I could show you photos! I have two pics of my forehead where I tried to clear up, and it went from crazy lumpy to clear slate in 20 days! Maybe I was just lucky, or this is exactly what my skin needed. I definitely would give it a go. A heads up... it is pretty painful for people like me with sensitive skin, but just think of the outcome :)"

10 / 10
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  • Mel...
  • Taken for 1 to 6 months
  • December 23, 2015

For Acne "Oh my gosh. I've been using this since August, and I thought my skin was truly hopeless. My skin is clear. When I was done with the three months, I still had cysts, and I was crying all the time because I missed my skin. My skin was never this bad, just comedonal acne and random pimples on my cheeks. While on Epiduo, I experienced like 15 cysts on my cheeks and forehead, and I was in pain. Be patient even after the three months. I just started doxy, but my skin has been clear for like 3 weeks, and it's beautiful and glowing. Thank you, Epiduo! You ruined my skin and saved it at the same time. It's so soft, and I have really red scarring, but it's apparently 'so superficial.' None of the scarring is deep."

10 / 10
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  • Zol...
  • August 23, 2016

For Acne "So I was prescribed this medication a while ago, but I basically gave up every time things got painful. That, for me, was about the 5th day in. I'd been told to persevere and that the pain and dryness would stop after the first 2 weeks. But I decided to only use it when I had breakouts. However, this medication brings out the acne before clearing it, so of course your acne is going to get worse before it gets better. HOWEVER, I now use it every day. I have very sensitive skin, so I can't use a lot of moisturizers because they burn. But I'm using some Garnier moisturizer and an oil-based one from Lush whenever my skin feels a little dry, and I have not had a painful night since. And no extreme dryness or flaking either. Brilliant!"

9 / 10
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  • Ale...
  • March 27, 2017

For Acne "Well... I've never had acne-prone skin. I have mixed-oily skin and I have some acne when I get stressed. That's the reason why I visited a dermatologist. The doctor recommended I use Epiduo (every night), after I wash my face with a foam (I use the same foam in the morning with a gel cream after it and a moisturizing cream, as many times as I want). The doctor informed me that this cream may affect me (redness, itching, dryness, pain), but my face got like sunburned and it was scratching me so much. I was afraid, and I stopped it yesterday. I don't know if I should continue using this cream."

3 / 10
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  • Yoo...
  • Taken for less than 1 month
  • November 10, 2013

For Acne "I am 23 with adult onset acne. I have tried so many things from natural products (honey, banana, cinnamon, etc.) to about every store-bought product in existence! Nothing helped. I've been on Epiduo for 4 days and have noticed my acne is already stopping. However, areas on my face are very dry with peeling, red, itchy, and painful to touch. Basically feels like a bad sunburn! I do expect that this should go away from other reviewers' results and plan to use a recommended lotion and avoid putting the Epiduo on the dry areas of my face for now. I am also on amoxicillin twice daily. I would recommend this so far!"

8 / 10
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  • Mer...
  • Taken for less than 1 month
  • October 25, 2015

For Acne "Since using Epiduo, I broke out in painful cysts on my face. Which defeats the purpose of why I used it in the first place. Two years ago, I had the worst breakouts ever. But that stopped after four months on Aldactone. My skin went from breaking out in four to five big painful cysts on my face to one tiny pimple around my period. I don’t wear foundation or concealer, as my skin's pretty clear, but not 100% clear. Which is why I asked my doctor for a topical treatment to remove old scars. But since applying Epiduo, my painful cysts returned, and it dried out my skin so bad, it’s itchy. I used to use Proactiv, which does clear scars, but Epiduo has the same ingredient, 2.5% benzoyl peroxide, so I’m confused. Hopefully in the near future, it does clear my scars, but I wish I never used Epiduo."

1 / 10
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  • JJD...
  • Taken for 1 to 6 months
  • December 7, 2024

For Acne "Wow! Epiduo really works. The first time I used the cream (pea size), my face was red, raw, and burnt for a few days. I started using it once a week, then two days a week, then three days a week, and so on. Now I have been using it since August, and I use it every other day. My face went really dry when I first started using it. I apply Vaseline around my eyes and mouth before applying Epiduo, as those are the areas that dry out. Once I’ve put on Epiduo, I leave it for about half an hour before applying the Simple Repairing Rich Moisturizer with 22% ceramide boosters. This is the only cream that gives my skin the moisture it needs. I had multiple spots before I started using this cream, around a month in, it got better. I have never felt so comfortable with my skin now. I’m so glad I braved the dry and sore skin at the start. Also, make sure you wear sunscreen every day, as your skin will get sensitive."

10 / 10
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  • Use...
  • Taken for 1 to 2 years
  • October 21, 2019

For Acne "I have been using Epiduo alongside lymecycline for over a year for my acne. Using it every day on my body caused issues. After 4 days of using it daily, I started to feel pain on my skin, it felt like it was burning, leaving red patches all over. After that, I felt more bumps on my face. However, on my chest and back, it has helped greatly. Although my acne comes back near my period, the Epiduo helps a lot. I don't use it daily, just every other day on my chest and back."

6 / 10
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  • Lau...
  • October 6, 2015

For Acne "I had cystic acne, although not much of my face is affected by it, but the area I do have it is extremely bad! I have just been put on a 6-month course of antibiotics and Epiduo. I have only been using it for a week and, like many of the reviews say, my skin has been very sore and even the mildest of wash/moisturizers still sting when applied. But I think I have found a solution! When I apply the Mario Badescu healing soothing mask after washing my face, I rinse that off and then apply Epiduo, I have absolutely no sting at all! I would recommend people trying this! As far as whether it works or not, I think it's far too early to say but I hope I'm one of the success stories!"

4 / 10
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  • Lub...
  • July 15, 2016

For Acne "I have been using this for 3 days, and I'm in awful pain, and my face looks terrible, like I have got really bad sunburn. Would not recommend anyone use this product, as my skin is flaking, and my moisturizer is causing too much extra pain."

2 / 10
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  • Chr...
  • July 26, 2014

For Acne "At first, it worked okay, then my acne was worse than when I started, and it even burned to apply the Epiduo, causing great pain. It is not right for everyone."

2 / 10
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  • Anonymous
  • Taken for less than 1 month
  • April 23, 2015

For Acne "This medicine works very well, and I'm seeing improvements after just a few days. However, it burns your face and hurts like hell."

8 / 10
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10 Report
  • rac...
  • Taken for less than 1 month
  • March 1, 2018

For Acne "Epiduo completely dried out my skin. I guess to clear acne you need to remove the oils, which is what it did. But it burned my skin and left me in pain for days. Redness and aching dried-out skin."

2 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.