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Temsirolimus

Generic Name: Temsirolimus (tem sir OH li mus)
Brand Name: Torisel

Uses of Temsirolimus:

  • It is used to treat kidney cancer.

What do I need to tell my doctor BEFORE I take Temsirolimus?

  • If you have an allergy to temsirolimus, sirolimus, or any other part of this medicine (temsirolimus).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have a high bilirubin level.
  • If you are taking St. John's wort. Do not take St. John's wort with this medicine. This medicine may not work as well.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with this medicine (temsirolimus).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Temsirolimus?

  • Tell all of your health care providers that you take this medicine (temsirolimus). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Avoid grapefruit and grapefruit juice.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • Some people who used this medicine have had deadly infections. The chance of infection may be higher if you take other drugs that weaken the immune system. Talk with your doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Talk with your doctor before getting any vaccines. Use with this medicine (temsirolimus) may either raise the chance of an infection or make the vaccine not work as well.
  • If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
  • Check your blood sugar as you have been told by your doctor.
  • This medicine may affect how wounds heal. If you need to have surgery, you may need to stop this medicine before surgery. Start taking it again after surgery as you have been told by your doctor. Talk with your doctor.
  • People taking this medicine (temsirolimus) who have brain or nervous system tumors may have a raised chance of bleeding in the brain. The chance may also be raised in people who are taking blood thinners with this medicine. Sometimes, this may be deadly. Talk with your doctor.
  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract have happened with this medicine (temsirolimus). Talk with the doctor.
  • Very bad and sometimes deadly infusion reactions have happened with this medicine. Call your doctor right away if you have chest pain, flushing, shortness of breath, very bad dizziness, or you pass out.
  • If you are 65 or older, use this medicine (temsirolimus) with care. You could have more side effects.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use birth control that you can trust.
  • If you are a man and your sex partner gets pregnant while you take this medicine or within 3 months after your last dose, call your doctor right away.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking this medicine (temsirolimus) and for 3 months after care ends.
  • If you get pregnant while taking this medicine or within 3 months after your last dose, call your doctor right away.

How is this medicine (Temsirolimus) best taken?

Use this medicine (temsirolimus) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Other drugs may be given before this medicine to help avoid side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat the does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
  • Very bad headache.
  • Feeling very tired or weak.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Coughing up blood.
  • Any unexplained bruising or bleeding.
  • Black, tarry, or bloody stools.
  • Stomach pain.
  • Loose stools (diarrhea).
  • Very bad and sometimes deadly lung problems have happened with this medicine (temsirolimus). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Very bad and sometimes deadly kidney problems have happened with this medicine. Call your doctor right away if you are unable to pass urine or if you have blood in the urine or a change in the amount of urine passed.

What are some other side effects of Temsirolimus?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Pimples (acne).
  • Upset stomach or throwing up.
  • Mouth irritation or mouth sores.
  • Hard stools (constipation).
  • Headache.
  • Back pain.
  • Muscle or joint pain.
  • Not able to sleep.
  • Dry skin.
  • Change in nails.
  • Nosebleed.
  • Runny nose.
  • Throat irritation.
  • Not hungry.
  • Change in taste.
  • Weight loss.
  • Feeling tired or weak.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Temsirolimus?

  • If you need to store this medicine (temsirolimus) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine (temsirolimus) or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine (temsirolimus). This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

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