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Temsirolimus Side Effects

Medically reviewed by Last updated on Sep 7, 2023.

Applies to temsirolimus: intravenous solution.

Serious side effects of Temsirolimus

Along with its needed effects, temsirolimus may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking temsirolimus:

More common

Less common

Incidence not known

Other side effects of Temsirolimus

Some side effects of temsirolimus may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to temsirolimus: intravenous solution.


Very common (10% or more): Increased AST (up to 38%)

Common (1% to 10%): Increased total bilirubin, increased ALT[Ref]


Very common (10% or more): Bacterial and viral infections (including abscess, bronchitis, cellulitis, herpes simplex, oral herpes, herpes zoster; up to 28.3%)

Common (1% to 10%): Sepsis, candidiasis, fungal infection, flu syndrome[Ref]


Common (1% to 10%): Allergic/hypersensitivity reactions[Ref]


Very common (10% or more): Dyspnea (up to 28%), cough (up to 29%), epistaxis (up to 21.5%), pharyngitis (up to 12%), pneumonia (up to 10.9%), rhinitis (up to 10%)

Common (1% to 10%): Upper respiratory tract infection, pleural effusion, sinusitis, interstitial lung disease/pneumonitis (including fatalities)

Uncommon (0.1% to 1%): Laryngitis

Postmarketing reports: Pneumocystis jiroveci pneumonia[Ref]


Very common (10% or more): Increased creatinine (up to 57%)

Common (1% to 10%): Renal failure[Ref]


Very common (10% or more): Decreased hemoglobin (up to 94%), decreased lymphocytes (up to 53%), anemia (up to 41.1%), decreased platelets (up to 40%), decreased leukocytes (up to 32%), thrombocytopenia (up to 30.2%), decreased neutrophils (up to 19%), neutropenia (up to 14.3%)

Common (1% to 10%): Leukopenia, lymphopenia[Ref]


Very common (10% or more): Chest pain (up to 16%)

Common (1% to 10%): Hypertension, venous thromboembolism (including deep vein thrombosis and pulmonary embolism, some fatal), thrombophlebitis, pericardial effusion[Ref]


Very common (10% or more): Rash (including eczema, exfoliative dermatitis, maculopapular rash, pustular rash, vesiculobullous rash; up to 47%), pruritus (up to 21.5%), nail disorder (up to 14%), dry skin (up to 11%), acne (up to 10%)

Common (1% to 10%): Folliculitis, ecchymosis, petechiae

Postmarketing reports: Stevens-Johnson syndrome[Ref]


Very common (10% or more): Asthenia (up to 51%), fatigue (up to 41.4%), edema (including facial and peripheral; up to 38%), pyrexia (up to 28.3%), pain (up to 28%)

Common (1% to 10%): Wound infection/post-operative wound infection, impaired wound healing

Postmarketing reports: Angioneurotic edema-type reactions, extravasations[Ref]


Very common (10% or more): Increased glucose (up to 89%), hyperglycemia (up to 26%)

Common (1% to 10%): Diabetes mellitus[Ref]


Very common (10% or more): Mucositis (including stomatitis, glossitis, mouth ulceration; up to 41%), nausea (up to 37%), diarrhea (up to 34%), abdominal pain (up to 21%), constipation (up to 20%), vomiting (up to 19%)

Common (1% to 10%): Bowel perforation (including fatal cases), gastrointestinal hemorrhage, rectal hemorrhage, gastritis, dysphagia, abdominal distension, oral pain, gingivitis, mouth pain, oral moniliasis, hemorrhoidal hemorrhage

Uncommon (0.1% to 1%): Intestinal/duodenal perforation, lip hemorrhage, mouth hemorrhage[Ref]


Very common (10% or more): Unspecified urogenital adverse reaction (up to 30%), urinary tract infection (including cystitis, dysuria, hematuria, urinary frequency; up to 15%)[Ref]


Very common (10% or more): Increased total cholesterol (up to 87%), increased triglycerides (up to 83%), increased alkaline phosphatase (up to 68%), decreased phosphorus (up to 49%), decreased calcium (up to 39%), decreased appetite (up to 33.3%), anorexia (up to 32%), hyperlipidemia (up to 27%), decreased potassium (up to 21%), weight loss (up to 19%), hypercholesterolemia (up to 18.8%), hypertriglyceridemia (up to 17.4%), hypokalemia (up to 13.7%), increased lactic dehydrogenase (up to 11%)

Common (1% to 10%): Dehydration, hypocalcemia, hypophosphatemia[Ref]


Very common (10% or more): Back pain (up to 20%), arthralgia (up to 18%), muscle cramp (up to 12%)

Common (1% to 10%): Myalgia

Postmarketing reports: Rhabdomyolysis[Ref]

Nervous system

Very common (10% or more): Dysgeusia (including taste loss, taste perversion; up to 20%), headache (up to 17.1%)

Common (1% to 10%): Dizziness, paresthesia, somnolence, convulsion

Uncommon (0.1% to 1%): Intracranial hemorrhage

Postmarketing reports: Complex regional pain syndrome/reflex sympathetic dystrophy[Ref]


Common (1% to 10%): Conjunctivitis (including lacrimation disorder)

Uncommon (0.1% to 1%): Eye hemorrhage[Ref]


Very common (10% or more): Insomnia (up to 14%)

Common (1% to 10%): Depression, anxiety[Ref]


1. Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories. 2007.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.