Medically reviewed on July 4, 2018
Uses of Simbrinza:
- It is used to treat glaucoma.
- It is used to lower high eye pressure.
What do I need to tell my doctor BEFORE I take Simbrinza?
For all patients taking Simbrinza (brinzolamide and brimonidine):
- If you have an allergy to brinzolamide, brimonidine, or any other part of Simbrinza (brinzolamide and brimonidine).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have kidney disease.
- If you are taking any of these drugs: Acetazolamide or methazolamide.
- If you are breast-feeding or plan to breast-feed.
- If your child is younger than 2 years of age. Do not give Simbrinza (brinzolamide and brimonidine) to a child younger than 2 years of age.
This is not a list of all drugs or health problems that interact with Simbrinza (brinzolamide and brimonidine).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Simbrinza (brinzolamide and brimonidine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Simbrinza?
- Tell all of your health care providers that you take Simbrinza (brinzolamide and brimonidine). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Simbrinza (brinzolamide and brimonidine) affects you.
- Have your blood pressure checked often if you have heart disease.
- Have your eye pressure and eyesight checked as you have been told by the doctor.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- Tell your doctor if you have an eye infection, eye injury, or will be having eye surgery.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Simbrinza (brinzolamide and brimonidine) while you are pregnant.
How is this medicine (Simbrinza) best taken?
Use Simbrinza (brinzolamide and brimonidine) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- For the eye only.
- Shake well before use.
- Take out contact lenses before using Simbrinza (brinzolamide and brimonidine). Lenses may be put back in 15 minutes after Simbrinza (brinzolamide and brimonidine) is given. Do not put contacts back in if your eyes are irritated or infected.
- Do not touch the container tip to the eye, lid, or other skin.
- Tilt your head back and drop drug into the eye.
- After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
- If more than 1 drug is being used in the same eye, use each drug at least 5 minutes apart.
- Do not use if the solution is cloudier than usual, leaking, or has particles.
- Do not use if the liquid changes color.
What do I do if I miss a dose?
- Use a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not use 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Change in eyesight, eye pain, or very bad eye irritation.
- If bright lights bother your eyes.
- Rarely, very bad effects have happened with sulfa drugs. Sometimes, these have been deadly. These effects have included liver problems, blood problems, and very bad skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis). Call your doctor right away if you have a rash; red, swollen, blistered, or peeling skin; red or irritated eyes; sores in your mouth, throat, nose, or eyes; fever, chills, or sore throat; cough that is new or worse; feeling very tired or weak; any bruising or bleeding; or signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Simbrinza?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Blurred eyesight.
- Eye irritation.
- Dry mouth.
- Change in taste.
- Feeling that something is in the eye.
- Feeling sleepy.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Simbrinza?
- Store liquid (solution) in the original container at room temperature. Keep the cap tightly closed. Throw away when the date on the bottle has been reached.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Simbrinza (brinzolamide and brimonidine), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Simbrinza (brimonidine / brinzolamide ophthalmic)
- Simbrinza Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- 8 Reviews
- Drug class: ophthalmic glaucoma agents