Generic Name: rizatriptan (RYE-za-TRIP-tan)
Brand Name: Maxalt
Rizatriptan is used for:
Treating migraine headaches with or without aura (eg, flashing lights, wavy lines, dark spots). It should not be used to prevent migraines or to treat cluster headaches.
Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches.
Do NOT use rizatriptan if:
- you are allergic to any ingredient in rizatriptan
- you have a history of ischemic heart disease (eg, angina, a heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, a stroke, a transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)
- you have uncontrolled high blood pressure
- you have certain types of migraine headache (hemiplegic, basilar)
- you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
- you have used certain other migraine medicines within the past 24 hours (eg, an ergot derivative [eg, dihydroergotamine, methysergide], another serotonin 5-HT1 receptor agonist [eg, eletriptan, rizatriptan])
- the patient is a child who weighs less than 88 lbs (40 kg) and is also taking propranolol
Contact your doctor or health care provider right away if any of these apply to you.
Before using rizatriptan:
Some medical conditions may interact with rizatriptan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are very overweight, past menopause, or you smoke
- if you have a history of other types of headaches (eg, cluster headaches)
- if you have a history of diabetes, kidney or liver problems, heart problems, chest pain, shortness of breath, high blood cholesterol, or high blood pressure
- if a family member has had heart disease or a stroke
- if you are a man who is older than 40 years old
- if you are on dialysis
Some MEDICINES MAY INTERACT with rizatriptan. Tell your health care provider if you are taking any other medicines, especially any of the following:
- MAOIs (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, venlafaxine), sibutramine, or tricyclic antidepressants (eg, amitriptyline) because severe side effects, such as a reaction that may include fever, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur
- Ergot alkaloids (eg, ergotamine) or propranolol because they may increase the risk of rizatriptan's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if rizatriptan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use rizatriptan:
Use rizatriptan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with rizatriptan. Talk to your pharmacist if you have questions about this information.
- Take rizatriptan by mouth with or without food.
- Take rizatriptan with plenty of fluid.
- It is best to take a dose of rizatriptan as soon as you notice symptoms of a migraine attack.
- For adults: If your migraine symptoms go away and then come back, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.
- For children: If migraine symptoms go away and then come back, check with the child's doctor for instructions. Safety and effectiveness of using more than 1 dose within 24 hours in children have not been confirmed.
- If your symptoms do not improve after the first dose, do not take a second dose for the same attack. Contact your doctor.
- Do not take more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor.
- If you miss a dose of rizatriptan and you still have a headache, follow your doctor's dosing instructions. Contact your doctor right away if you are unsure of what to do if you miss a dose. Do not take rizatriptan more often than prescribed. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use rizatriptan.
Important safety information:
- Rizatriptan may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use rizatriptan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Overuse of rizatriptan can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
- Rizatriptan is not intended to prevent or reduce the number of migraine attacks that you experience.
- If you have a headache that is different from your usual migraine attacks, check with your doctor before using rizatriptan.
- Rarely, serious heart problems (eg, a heart attack, irregular heartbeat) have been reported within a few hours of using rizatriptan. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; numbness of an arm or leg; severe stomach pain, dizziness, or vomiting; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.
- Serotonin syndrome is a possibly fatal syndrome that can be caused by rizatriptan. Your risk may be greater if you take rizatriptan with certain other medicines (eg, MAOIs, SNRIs, SSRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; muscle spasms; trouble walking; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
- Lab tests, including heart function, may be performed while you use rizatriptan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Rizatriptan should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using rizatriptan while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use rizatriptan, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of rizatriptan:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; drowsiness; dry mouth; fatigue; nausea; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody diarrhea; burning, numbness, or tingling of the hands or feet; chest heaviness; chest, neck, or jaw pain, tightness, or pressure; decreased coordination; excessive sweating; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation); muscle spasms; seizure; severe nausea, vomiting, or diarrhea; severe or persistent headache or dizziness; shortness of breath; stomach pain; symptoms of stroke (eg, confusion, one-sided weakness, slurred speech); tremor; unusual weakness; very cold or blue fingers or toes; vision changes or loss of vision.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; fast, slow, or irregular heartbeat; shortness of breath; unusual dizziness or drowsiness; vomiting.Proper storage of rizatriptan:
Store rizatriptan at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep rizatriptan out of the reach of children and away from pets.
- If you have any questions about rizatriptan, please talk with your doctor, pharmacist, or other health care provider.
- Rizatriptan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take rizatriptan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about rizatriptan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to rizatriptan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using rizatriptan.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: antimigraine agents