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Generic Name: Riociguat (rye oh SIG ue at)
Brand Name: Adempas

Medically reviewed by Last updated on Apr 1, 2020.


  • Do not take riociguat if you are pregnant. This medicine may cause harm to the unborn baby if you take it while you are pregnant. A pregnancy test will be done before starting riociguat to show that you are NOT pregnant. Pregnancy tests will also be done every month while you take riociguat and for 1 month after you stop taking it. If you get pregnant or plan on getting pregnant while taking riociguat, call your doctor right away.
  • Use 2 kinds of birth control during treatment and for 1 month after your last dose.

Uses of Riociguat:

What do I need to tell my doctor BEFORE I take Riociguat?

  • If you have an allergy to riociguat or any other part of riociguat.
  • If you are allergic to riociguat; any part of riociguat; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have a health problem called pulmonary veno-occlusive disease (PVOD).
  • If you have pneumonia.
  • If you are taking any of these drugs: Amyl nitrate, avanafil, dipyridamole, a nitrate drug like nitroglycerin, sildenafil, tadalafil, theophylline, or vardenafil.
  • If you are breast-feeding. Do not breast-feed while you take riociguat.

This is not a list of all drugs or health problems that interact with riociguat.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take riociguat with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Riociguat?

  • Tell all of your health care providers that you take riociguat. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how riociguat affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • Severe and sometimes deadly bleeding problems have happened with riociguat.
  • If you start or stop smoking, talk with your doctor. How much drug you take may need to be changed.
  • Check your blood pressure as you have been told.
  • Do not take riociguat within 24 hours of taking sildenafil. Do not take riociguat within 24 hours before or 48 hours after taking tadalafil.
  • If you are a woman and you miss a period, have unprotected sex, or think that your birth control has not worked, call your doctor right away.

How is this medicine (Riociguat) best taken?

Use riociguat as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • If you cannot swallow tablets, the tablet may be crushed and mixed with water or soft food like applesauce. Take the mixture right away. Do not store for future use.
  • Keep taking riociguat as you have been told by your doctor or other health care provider, even if you feel well.
  • Do not take antacids that have aluminum or magnesium in them within 1 hour of riociguat.
  • Your dose may be changed if you have side effects.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you miss 3 days of riociguat, call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Dizziness or passing out.
  • A heartbeat that does not feel normal.
  • Trouble swallowing.
  • Swelling of belly.
  • Swelling in the arms or legs.
  • Chest pain.
  • Pale skin.
  • Feeling very tired or weak.

What are some other side effects of Riociguat?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Riociguat?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time riociguat is refilled. If you have any questions about riociguat, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.