Generic Name: propofol (PROE-poe-fol)
Brand Name: Diprivan
Propofol is used for:
Starting or maintaining anesthesia (lack of sensation or feeling) during certain surgeries, tests, or procedures. It may also be used for sedation (making you sleepy or making you go to sleep lightly) in certain patients. It may also be used for other conditions as determined by your doctor.
Propofol is a general anesthetic. It is unknown exactly how propofol works.
Do NOT use propofol if:
- you are allergic to any ingredient in propofol or to lipid products
- you are allergic to eggs, egg products, soybeans, or soy products
Contact your doctor or health care provider right away if any of these apply to you.
Before using propofol:
Some medical conditions may interact with propofol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, slow or irregular heartbeat), liver or kidney problems, high or low blood pressure, low blood volume, nervous system problems, lung or breathing problems, or seizures (eg, epilepsy)
- if you have inflammation of the pancreas (pancreatitis), high lipid levels in the blood, fat metabolism problems, moderate to severe burns, or increased pressure in the brain
- if you have an infection, fever, or recent injury, or if you have felt generally unwell for some time
- if you have diarrhea, poor health, or if you are dehydrated
Some MEDICINES MAY INTERACT with propofol. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Benzodiazepines (eg, alprazolam), narcotic pain relievers (eg, morphine), or other sedatives (eg, chloral hydrate) because they may increase the risk of propofol's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if propofol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use propofol:
Use propofol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Propofol is administered as an injection at your doctor's office, hospital, or clinic.
- Do not use propofol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If you will be receiving propofol for a long period of time, your doctor may give you a zinc mineral supplement. Discuss any questions or concerns with your health care provider.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of propofol, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use propofol.
Important safety information:
- Propofol may decrease mental alertness for some time after use. This effect may be worse if you drink alcohol or take certain medicines. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Use caution signing legal documents.
- Do not drink alcohol before using propofol and for at least 8 hours after using it.
- Propofol may rarely cause a serious and sometimes fatal condition called propofol infusion syndrome (PRIS). The risk of PRIS may be greater if you receive high doses of propofol or use it for a prolonged period of time. The risk may also be greater if you have certain other medical conditions, including a severe brain injury or severe infection. Contact your doctor right away if you experience dark urine or decreased urination; fast breathing; fast or irregular heartbeat; severe or unusual drowsiness, nausea, or vomiting; severe or unusual muscle pain or weakness; shortness of breath; sluggishness; sudden, unexplained weight gain; or swelling of the hands, ankles, legs, or feet.
- Use propofol with caution in the ELDERLY; they may be more sensitive to its effects.
- Propofol should not be used to start anesthesia in CHILDREN younger than 3 years old. Propofol should not be used to maintain anesthesia in CHILDREN younger than 2 months old. Propofol should not be used for sedation in CHILDREN younger than 18 years old. Safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using propofol while you are pregnant. Propofol is found in breast milk. Do not breast-feed while taking propofol.
Possible side effects of propofol:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; drowsiness; headache; lack of coordination; mild pain at the injection site; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); change in the color of urine; chest pain; confusion; cough; decreased urination; fainting; fast, slow, or irregular heartbeat; fever; involuntary muscle movements or twitching; mental or mood changes; (eg, agitation); muscle pain; pain, burning, redness, or swelling at the injection site; rigid muscles; seizures; severe or persistent dizziness, headache, or light-headedness; severe stomach or back pain (with or without nausea or vomiting); shortness of breath; slow, fast, or difficult breathing; unusual tiredness or weakness; vision changes; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of propofol:
Propofol is handled and stored by a health care provider. Keep propofol out of the reach of children and away from pets.
- If you have any questions about propofol, please talk with your doctor, pharmacist, or other health care provider.
- Propofol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take propofol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about propofol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to propofol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using propofol.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about propofol
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
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