Generic Name: labetalol (la-BAYT-a-lol)
Brand Name: Trandate
Labetalol is used for:
Treating high blood pressure. It may be used alone or in combination with other medicines, such as diuretics. It may also be used for other conditions as determined by your doctor.
Labetalol is an adrenergic receptor blocker. It works by blocking both alpha and beta receptors in the body, which lowers blood pressure.
Do NOT use labetalol if:
- you are allergic to any ingredient in labetalol
- you have second- or third-degree (complete) heart block, moderate to severe first-degree heart block after a heart attack, heart failure, a certain abnormal electrocardiogram (ECG) (prolonged QT interval), or shock caused by serious heart problems
- you have asthma, obstructive airway disease, or other breathing disorders
- you have severe slow heartbeat or severe low blood pressure
Contact your doctor or health care provider right away if any of these apply to you.
Before using labetalol:
Some medical conditions may interact with labetalol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have diabetes, an adrenal gland tumor (pheochromocytoma), lung or breathing problems (eg, bronchitis, chronic obstructive pulmonary disease [COPD], emphysema), kidney problems, liver problems, or thyroid problems
- if you have heart problems (eg, first-degree heart block, slow heartbeat, irregular heartbeat, Wolff-Parkinson-White syndrome, sick sinus syndrome), low blood pressure, a history of heart failure, or you have had a recent heart attack
- if you are scheduled to have surgery, including cataract surgery, or have recently had surgery
Some MEDICINES MAY INTERACT with labetalol. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Calcium channel blockers (eg, verapamil), cimetidine, or digoxin because they may increase the risk of labetalol's side effects
- General anesthetics (eg, halothane), nitroglycerin, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by labetalol
- Beta-agonists (eg, albuterol) because their effectiveness may be decreased by labetalol
This may not be a complete list of all interactions that may occur. Ask your health care provider if labetalol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use labetalol:
Use labetalol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Labetalol is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using labetalol at home, a health care provider will teach you how to use it. Be sure you understand how to use labetalol. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use labetalol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- Because severe dizziness may occur when standing, remain lying down immediately after and for up to 3 hours after receiving your dose. Talk with your doctor about how to gradually become active after your dose.
- If you miss a dose of labetalol, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use labetalol.
Important safety information:
- Labetalol may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use labetalol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Labetalol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- Do not suddenly stop using labetalol without first checking with your doctor. Suddenly stopping labetalol may result in chest pain or temporary symptoms such as shaking, sweating, headache, irregular heartbeat, and general unwell feeling. If your doctor decides that you should stop using labetalol, your dosage should be reduced over a period of 1 to 2 weeks and you should be carefully monitored.
- Tell your doctor or dentist that you use labetalol before you receive any medical or dental care, emergency care, or surgery.
- If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk of an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using labetalol.
- Labetalol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using labetalol.
- If your doctor has instructed you to check your blood pressure and heart rate regularly, be sure to do so.
- Diabetes patients - Labetalol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Diabetes patients - Labetalol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Lab tests, including liver function, may be performed while you use labetalol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use labetalol with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, lightheadedness, or fainting.
- Labetalol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using labetalol while you are pregnant. Labetalol is found in breast milk. If you are or will be breast-feeding while you use labetalol, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of labetalol:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; indigestion; lightheadedness; nausea; pain, swelling, or redness at the injection site; stuffy nose; temporary tingling of the scalp; unusual tiredness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; dark urine; decreased sexual ability; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes (eg, depression); muscle pain or tenderness; pale stools; persistent cough; persistent loss of appetite; right upper stomach pain; severe or persistent dizziness; shortness of breath; swelling of the hands or feet; unexplained or sudden weight gain; unusual bruising or bleeding; weakness; wheezing; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; seizures; severe dizziness or lightheadedness, especially when standing; shortness of breath; slow heartbeat.Proper storage of labetalol:
Labetalol is usually handled and stored by a health care provider. If you are using labetalol at home, store labetalol as directed by your pharmacist or health care provider. Keep labetalol out of the reach of children and away from pets.
- If you have any questions about labetalol, please talk with your doctor, pharmacist, or other health care provider.
- Labetalol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take labetalol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about labetalol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to labetalol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using labetalol.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: non-cardioselective beta blockers