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Labetalol Side Effects

In Summary

Commonly reported side effects of labetalol include: symptomatic orthostatic hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to labetalol: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by labetalol. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking labetalol:

Less common:
  • Blurred vision or other changes in vision
  • chills
  • cold sweats
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • shortness of breath
  • swelling of face, fingers, feet, or lower legs
  • tightness in chest
  • wheezing

If any of the following symptoms of overdose occur while taking labetalol, get emergency help immediately:

Symptoms of overdose:
  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with labetalol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Nausea
Less common:
  • Acid or sour stomach
  • belching
  • change in taste or bad, unusual, or unpleasant (after) taste
  • decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • headache
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • not able to ejaculate semen
  • rash
  • sensation of spinning
  • stomach discomfort, upset, or pain
  • stuffy nose
Rare
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • increased sweating
  • vomiting

For Healthcare Professionals

Applies to labetalol: compounding powder, intravenous solution, oral tablet

Cardiovascular

Common (1% to 10%): Edema, postural hypotension
Frequency not reported: Bradycardia, heart block, heart failure, hypotension, ankle edema, increase of an existing intermittent claudication, postural hypotension, cold or cyanotic extremities, Raynaud's phenomenon, paresthesia of the extremities, syncope[Ref]

Dermatologic

Uncommon (0.1% to 1%): Increased sweating
Frequency not reported: Systemic lupus erythematosus, rashes (e.g., generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, facial erythema, Peyronie's disease, reversible alopecia)[Ref]

Endocrine

Frequency not reported: Masking of the normal response to hypoglycemia (sweating and tachycardia); this may be important in some patients with diabetes mellitus[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, vomiting
Uncommon (0.1% to 1%): Diarrhea
Frequency not reported: Epigastric pain[Ref]

Genitourinary

Common (1% to 10%): Ejaculation failure, impotence
Frequency not reported: Difficulty in micturition (including acute urinary bladder retention)[Ref]

Hepatic

Common (1% to 10%): Transient elevations of liver function tests
Frequency not reported: Hepatic necrosis, hepatitis, cholestatic jaundice[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea), anaphylactoid reactions[Ref]

Immunologic

Frequency not reported: Antimitochondrial antibodies[Ref]

Metabolic

Very rare (less than 0.01%): Hyperkalemia[Ref]

Musculoskeletal

Frequency not reported: Muscle cramps, toxic myopathy[Ref]

Nervous system

Very common (10% or more): Dizziness (11%)
Common (1% to 10%): Headache, taste distortion, vertigo, paresthesia, scalp tingling
Uncommon (0.1% to 1%): Drowsiness
Frequency not reported: Tremor[Ref]

Ocular

Common (1% to 10%): Vision abnormality
Frequency not reported: Dry eyes
Postmarketing reports: Intraoperative Floppy Iris Syndrome (IFIS) observed during cataract surgery[Ref]

Respiratory

Common (1% to 10%): Nasal stuffiness, dyspnea
Frequency not reported: Bronchospasm, interstitial lung disease[Ref]

Other

Common (1% to 10%): Fatigue, asthenia
Frequency not reported: Positive antinuclear factor[Ref]

Psychiatric

Frequency not reported: Depressed mood and lethargy, hallucinations, psychoses, confusion, sleep disturbances, nightmares[Ref]

References

1. "Product Information. Labetalol Hydrochloride (labetalol)." Watson Pharmaceuticals, Parsippany, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for labetalol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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