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Labetalol Side Effects

Medically reviewed by Last updated on Feb 11, 2024.

Applies to labetalol: oral tablet. Other dosage forms:

Serious side effects of Labetalol

Along with its needed effects, labetalol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking labetalol:

Less common

Get emergency help immediately if any of the following symptoms of overdose occur while taking labetalol:

Symptoms of overdose

Other side effects of Labetalol

Some side effects of labetalol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to labetalol: compounding powder, intravenous solution, oral tablet.


Common (1% to 10%): Edema, postural hypotension

Frequency not reported: Bradycardia, heart block, heart failure, hypotension, ankle edema, increase of an existing intermittent claudication, postural hypotension, cold or cyanotic extremities, Raynaud's phenomenon, paresthesia of the extremities, syncope[Ref]


Uncommon (0.1% to 1%): Increased sweating

Frequency not reported: Systemic lupus erythematosus, rashes (e.g., generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, facial erythema, Peyronie's disease, reversible alopecia)[Ref]


Frequency not reported: Masking of the normal response to hypoglycemia (sweating and tachycardia); this may be important in some patients with diabetes mellitus[Ref]


Common (1% to 10%): Nausea, dyspepsia, vomiting

Uncommon (0.1% to 1%): Diarrhea

Frequency not reported: Epigastric pain[Ref]


Common (1% to 10%): Ejaculation failure, impotence

Frequency not reported: Difficulty in micturition (including acute urinary bladder retention)[Ref]


Common (1% to 10%): Transient elevations of liver function tests

Frequency not reported: Hepatic necrosis, hepatitis, cholestatic jaundice[Ref]


Rare (less than 0.1%): Hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea), anaphylactoid reactions[Ref]


Frequency not reported: Antimitochondrial antibodies[Ref]


Very rare (less than 0.01%): Hyperkalemia[Ref]


Frequency not reported: Muscle cramps, toxic myopathy[Ref]

Nervous system

Very common (10% or more): Dizziness (11%)

Common (1% to 10%): Headache, taste distortion, vertigo, paresthesia, scalp tingling

Uncommon (0.1% to 1%): Drowsiness

Frequency not reported: Tremor[Ref]


Common (1% to 10%): Vision abnormality

Frequency not reported: Dry eyes

Postmarketing reports: Intraoperative Floppy Iris Syndrome (IFIS) observed during cataract surgery[Ref]


Common (1% to 10%): Nasal stuffiness, dyspnea

Frequency not reported: Bronchospasm, interstitial lung disease[Ref]


Common (1% to 10%): Fatigue, asthenia

Frequency not reported: Positive antinuclear factor[Ref]


Frequency not reported: Depressed mood and lethargy, hallucinations, psychoses, confusion, sleep disturbances, nightmares[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Labetalol Hydrochloride (labetalol). Watson Pharmaceuticals. 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.