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Ketorolac (Nasal)

Generic Name: Ketorolac (Nasal) (KEE toe role ak)
Brand Name: Sprix

Medically reviewed on Sep 5, 2018

Warning

  • This medicine may raise the chance of heart and blood vessel side effects like heart attack and stroke. If these happen, they can be deadly. The risk of these side effects may be greater if you have heart disease or risks for heart disease. However, the risk may also be raised in people who do not have heart disease or risks for heart disease. The risk of these health problems can happen as soon as the first weeks of using ketorolac (nasal) and may be greater with higher doses or with long-term use. Do not use ketorolac (nasal) right before or after bypass heart surgery.
  • This medicine may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleeding. The risk is greater in older people. The risk is also greater in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs. Talk with the doctor.

Uses of Ketorolac:

  • It is used to ease pain.
  • This medicine is only to be used for short-term pain (up to 5 days total). It may cause unsafe side effects if taken more than 5 days.

What do I need to tell my doctor BEFORE I take Ketorolac?

For all patients taking ketorolac (nasal):

  • If you have an allergy to ketorolac tromethamine or any other part of ketorolac (nasal).
  • If you have an allergy to EDTA.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have gotten nasal polyps or had swelling of the mouth, face, lips, tongue, or throat; unusual hoarseness; or trouble breathing with aspirin or NSAID use.
  • If you have had any of these health problems: Bleeding in the brain, bleeding problems, hole in the GI (gastrointestinal) tract, recent GI bleeding, kidney disease, or ulcer disease.
  • If you are having surgery, talk with your doctor.
  • If you are having trouble getting pregnant or you are having your fertility checked.
  • If you are pregnant or may be pregnant. Do not take ketorolac (nasal) if you are in the third trimester of pregnancy. You may also need to avoid ketorolac (nasal) at other times during pregnancy. Talk with your doctor to see when you need to avoid taking ketorolac (nasal) during pregnancy.
  • If you are taking any of these drugs: Aspirin, pentoxifylline, probenecid, or any nonsteroidal anti-inflammatory drug (NSAID).
  • If you are taking a salicylate drug like aspirin.
  • If you are taking pemetrexed.

Children:

  • If your child is younger than 2 years of age. Do not give ketorolac (nasal) to a child younger than 2 years of age.

This is not a list of all drugs or health problems that interact with ketorolac (nasal).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ketorolac (nasal) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Ketorolac?

  • Tell all of your health care providers that you take ketorolac (nasal). This includes your doctors, nurses, pharmacists, and dentists.
  • If you are 65 or older or weigh less than 110 pound, you may need a smaller dose. You could have more side effects.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
  • Talk with your doctor before you drink alcohol.
  • If you smoke, talk with your doctor.
  • If you have asthma, talk with your doctor. You may be more sensitive to ketorolac (nasal).
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take ketorolac (nasal) for longer than you were told by your doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.
  • The chance of heart attack and heart-related death is raised in people taking drugs like this one after a recent heart attack. People taking drugs like this one after a first heart attack were also more likely to die in the year after the heart attack compared with people not taking drugs like this one. Talk with the doctor.
  • If you are taking aspirin to help prevent a heart attack, talk with your doctor.
  • This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking ketorolac (nasal) with your other drugs.
  • Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • This medicine is not approved for use in children. Talk with the doctor.
  • NSAIDs like ketorolac (nasal) may affect egg release (ovulation) in women. This may cause you to not be able to get pregnant. This goes back to normal when ketorolac (nasal) is stopped. Talk with your doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking ketorolac (nasal), call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Ketorolac) best taken?

Use ketorolac (nasal) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take ketorolac (nasal) by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • If you get ketorolac (nasal) in your eyes, wash right away with water. If you have eye irritation that lasts or a change in eyesight, call your doctor.
  • Blow your nose before use.
  • Read and follow how to use facts given with spray. Make sure you use the spray the right way.
  • You will need to prepare the bottle before first use. Follow what you have been told by the doctor or read the package insert.
  • Spray up the nose only. Do not spray onto the wall joining the two nostrils.
  • Put the cap back on after you are done using your dose.
  • Use a new spray bottle each day and throw away old spray used the day before.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

  • If you use ketorolac (nasal) on a regular basis, use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses at the same time or extra doses.
  • Many times ketorolac (nasal) is used on an as needed basis. Do not use more often than told by the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Feeling very tired or weak.
  • Very bad belly pain.
  • Very bad swelling or pain of hands or feet.
  • Very loose stools (diarrhea).
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Ketorolac?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Nose pain or irritation.
  • Runny nose.
  • More tears.
  • Throat irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Ketorolac?

  • Store unopened containers in a refrigerator. Do not freeze.
  • Store opened nose spray bottle at room temperature. Each bottle is only good for 24 hours. Throw away any unused drug after 24 hours even if it feels like there is more drug left.
  • Protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time ketorolac (nasal) is refilled. If you have any questions about ketorolac (nasal), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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