Empagliflozin and Linagliptin
Generic Name: Empagliflozin and Linagliptin (em pa gli FLOE zin & lin a GLIP tin)
Brand Name: Glyxambi
Medically reviewed on July 4, 2018
Uses of Empagliflozin and Linagliptin:
- It is used to lower blood sugar in patients with high blood sugar (diabetes).
- It is used to lower the chance of death from heart disease in certain people.
What do I need to tell my doctor BEFORE I take Empagliflozin and Linagliptin?
- If you have an allergy to empagliflozin and linagliptin or any part of empagliflozin and linagliptin.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Acidic blood problem or type 1 diabetes.
- If you have kidney disease.
- If you are pregnant or may be pregnant. Do not take empagliflozin and linagliptin if you are in the second or third trimester of pregnancy.
- If you are breast-feeding. Do not breast-feed while you take empagliflozin and linagliptin.
This is not a list of all drugs or health problems that interact with empagliflozin and linagliptin.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take empagliflozin and linagliptin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Empagliflozin and Linagliptin?
- Tell all of your health care providers that you take empagliflozin and linagliptin. This includes your doctors, nurses, pharmacists, and dentists.
- Low blood sugar can happen. The chance of low blood sugar may be raised when empagliflozin and linagliptin is used with other drugs for high blood sugar (diabetes). Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do if you get low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
- Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- If you are dehydrated, talk with your doctor.
- If loose stools (diarrhea) happen or you are throwing up, call your doctor. You will need to drink more fluids to keep from losing too much fluid.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take empagliflozin and linagliptin.
- It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.
- Talk with your doctor before you drink alcohol.
- Very bad and sometimes deadly pancreas problems (pancreatitis) have happened with empagliflozin and linagliptin. This could happen at any time during care. Signs of pancreatitis include very bad stomach pain, very bad back pain, or very upset stomach or throwing up. Call your doctor right away if you have any of these signs.
- Too much acid in the blood or urine (ketoacidosis) and very bad urinary tract infections (UTIs) have happened with empagliflozin and linagliptin. Ketoacidosis can be deadly. Both of these health problems may need to be treated in a hospital. Talk with the doctor.
- Kidney problems have happened with empagliflozin and linagliptin. Sometimes, kidney problems may need to be treated in the hospital. Dialysis may also be needed. Talk with your doctor.
- Heart failure has happened in people taking drugs like this one. Tell your doctor if you have ever had heart failure or kidney problems. Call your doctor right away if you feel very tired or you have shortness of breath, a big weight gain, or swelling in the arms or legs.
- If you are 65 or older, use empagliflozin and linagliptin with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking empagliflozin and linagliptin, call your doctor right away.
How is this medicine (Empagliflozin and Linagliptin) best taken?
Use empagliflozin and linagliptin as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Keep taking empagliflozin and linagliptin as you have been told by your doctor or other health care provider, even if you feel well.
- To gain the most benefit, do not miss doses.
- Take with or without food.
- Take in the morning.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Check your blood sugar as you have been told by your doctor.
- Talk with your doctor about which glucose tests are best to use.
- Follow the diet and workout plan that your doctor told you about.
- If you are on a low-salt or salt-free diet, talk with your doctor.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat the does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- For females, vaginal yeast infection. Report itching or discharge.
- For men, yeast infection of the penis. Report pain, swelling, rash, or discharge.
- Flaking, peeling, or swelling of the skin.
- Very bad headache.
- Drugs like this one may cause joint pain that can be very bad and disabling. Call your doctor right away if you have very bad joint pain or any joint pain that does not go away.
- A skin reaction called bullous pemphigoid has happened with drugs like this one. Sometimes, people have had to go to the hospital. Call your doctor right away if you have blisters or if your skin starts to break down.
What are some other side effects of Empagliflozin and Linagliptin?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Empagliflozin and Linagliptin?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time empagliflozin and linagliptin is refilled. If you have any questions about empagliflozin and linagliptin, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about empagliflozin/linagliptin
- Empagliflozin/linagliptin Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 15 Reviews
- Drug class: antidiabetic combinations
Other brands: Glyxambi