Generic name: Diphenhydramine/
Brand name: Benadryl-D
Drug class: Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on Mar 29, 2022.
Uses of Diphenhydramine/
- It is used to treat nose stuffiness.
- It is used to ease allergy signs.
What do I need to tell my doctor BEFORE I take Diphenhydramine/
- If you have an allergy to any part of this medicine (diphenhydramine/pseudoephedrine tablets).
- If you are allergic to this medicine (diphenhydramine/
pseudoephedrine tablets); any part of this medicine (diphenhydramine/ pseudoephedrine tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
This is not a list of all drugs or health problems that interact with this medicine (diphenhydramine/
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check
to make sure that it is safe for you to take this medicine (diphenhydramine/
What are some things I need to know or do while I take Diphenhydramine/
- Tell all of your health care providers that you take this medicine (diphenhydramine/
pseudoephedrine tablets). This includes your doctors, nurses, pharmacists, and dentists.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- Do not take this medicine (diphenhydramine/
pseudoephedrine tablets) for longer than you were told by your doctor.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (diphenhydramine/
pseudoephedrine tablets) affects you.
- Avoid drinking alcohol while taking this medicine (diphenhydramine/
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Use with care in children. Talk with the doctor.
- Do not use with other products that have diphenhydramine.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (diphenhydramine/
pseudoephedrine tablets) while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Diphenhydramine/
Pseudoephedrine Tablets) best taken?
Use this medicine (diphenhydramine/
- Take with or without food. Take with food if it causes an upset stomach.
What do I do if I miss a dose?
- If you take this medicine (diphenhydramine/
pseudoephedrine tablets) on a regular basis, take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times this medicine (diphenhydramine/
pseudoephedrine tablets) is taken on an as needed basis. Do not take more often than told by the doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
What are some other side effects of Diphenhydramine/
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling nervous and excitable.
- Not able to sleep.
- Feeling sleepy.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Diphenhydramine/
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (diphenhydramine/
pseudoephedrine tablets), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
More about diphenhydramine / pseudoephedrine
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (1)
- Drug class: upper respiratory combinations
- Other brands
- Benadryl Allergy Sinus
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.