Dapagliflozin and Metformin Extended-Release Tablets
Generic Name: Dapagliflozin and Metformin Extended-Release Tablets (dap a gli FLOE zin & met FOR min)
Brand Name: Xigduo XR
- Rarely, metformin may cause an acid health problem in the blood (lactic acidosis). The risk of lactic acidosis is higher in people with kidney problems and in people who take certain other drugs like topiramate. The risk is also higher in people with liver problems or heart failure, in older people (65 or older), or with alcohol use. If lactic acidosis happens, it can lead to other health problems and can be deadly. Lab tests to check the kidneys may be done while taking this medicine (dapagliflozin and metformin extended-release tablets). Talk with the doctor.
- Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like fast breathing, fast or slow heartbeat, a heartbeat that does not feel normal, very bad upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, very bad dizziness, feeling cold, or muscle pain or cramps.
- Do not take this medicine if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration).
- If you have liver disease, talk with your doctor.
- Talk with your doctor before you drink alcohol.
- If you are having an exam or test with contrast or have had one within the past 48 hours, talk with your doctor.
- Tell all of your health care providers that you take this medicine (dapagliflozin and metformin extended-release tablets). This includes your doctors, nurses, pharmacists, and dentists.
Uses of Dapagliflozin and Metformin Extended-Release Tablets:
- It is used to lower blood sugar in patients with high blood sugar (diabetes).
What do I need to tell my doctor BEFORE I take Dapagliflozin and Metformin Extended-Release Tablets?
- If you have an allergy to this medicine or any part of this medicine (dapagliflozin and metformin extended-release tablets).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Acidic blood problem, bladder cancer, or type 1 diabetes.
- If you have any of these health problems: Kidney disease or liver disease.
- If you have had a recent heart attack or stroke.
- If you are not able to eat or drink like normal, including before certain procedures or surgery.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with this medicine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (dapagliflozin and metformin extended-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Dapagliflozin and Metformin Extended-Release Tablets?
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
- Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- If loose stools (diarrhea) happen or you are throwing up, call your doctor. You will need to drink more fluids to keep from losing too much fluid.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (dapagliflozin and metformin extended-release tablets).
- It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.
- Check your blood sugar as you have been told by your doctor.
- Bladder cancer has happened in a few more people taking this medicine than in those taking other drugs for diabetes. It is not known if this drug led to these cases of bladder cancer. Talk with your doctor.
- Too much acid in the blood or urine (ketoacidosis) and very bad urinary tract infections (UTIs) have happened with this medicine (dapagliflozin and metformin extended-release tablets). Ketoacidosis can be deadly. Both of these health problems may need to be treated in a hospital. Talk with the doctor.
- Kidney problems have happened with this medicine. Sometimes, kidney problems may need to be treated in the hospital. Dialysis may also be needed. Talk with your doctor.
- It is common to have stomach problems like upset stomach, throwing up, or loose stools (diarrhea) when you start taking this medicine (dapagliflozin and metformin extended-release tablets). If you have stomach problems later during care, call your doctor right away. This may be a sign of an acid health problem in the blood (lactic acidosis).
- Follow the diet and workout plan that your doctor told you about.
- You may see something that looks like the tablet in your stool. This is normal and not a cause for concern. If you have questions, talk with your doctor.
- If you are on a low-salt or salt-free diet, talk with your doctor.
- If you are 65 or older, use this medicine with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (dapagliflozin and metformin extended-release tablets) while you are pregnant.
How is this medicine (Dapagliflozin and Metformin Extended-Release Tablets) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take this medicine (dapagliflozin and metformin extended-release tablets) with food.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- To gain the most benefit, do not miss doses.
- Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.
- Take in the morning.
- Swallow whole. Do not chew, break, or crush.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses unless told to do so by your doctor.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat the does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- For females, vaginal yeast infection. Report itching or discharge.
- For men, yeast infection of the penis. Report pain, swelling, rash, or discharge.
- Very bad belly pain.
- Low blood sugar can happen. The chance of low blood sugar may be raised when this medicine (dapagliflozin and metformin extended-release tablets) is used with other drugs for high blood sugar (diabetes). Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do if you get low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
What are some other side effects of Dapagliflozin and Metformin Extended-Release Tablets?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Upset stomach or throwing up.
- Nose or throat irritation.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Dapagliflozin and Metformin Extended-Release Tablets?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
This information should not be used to decide whether or not to take this medicine (dapagliflozin and metformin extended-release tablets) or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine (dapagliflozin and metformin extended-release tablets). This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
Review Date: October 4, 2017
More about dapagliflozin/metformin
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 5 Reviews – Add your own review/rating
- Drug class: antidiabetic combinations
Other brands: Xigduo XR