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Dapagliflozin / Metformin Dosage

Medically reviewed by Drugs.com. Last updated on May 6, 2022.

Applies to the following strengths: 2.5 mg-1000 mg; 5 mg-500 mg; 5 mg-1000 mg; 10 mg-500 mg; 10 mg-1000 mg

Usual Adult Dose for Diabetes Type 2

Initial dose:
Dapagliflozin 5 mg plus current metformin dose orally once a day

Dapagliflozin 10 mg plus current metformin dose orally once a day

Maximum dose: Dapagliflozin 10 mg-metformin 2000 mg per day

Comments:

Uses:

Usual Adult Dose for Heart Failure

Initial dose:
Dapagliflozin 5 mg plus current metformin dose orally once a day

Dapagliflozin 10 mg plus current metformin dose orally once a day

Maximum dose: Dapagliflozin 10 mg-metformin 2000 mg per day

Comments:

Uses:

Renal Dose Adjustments

eGFR 45 mL/min/1.73 m2 or greater: No adjustment recommended.
eGFR 30 to less than 45 mL/min/1.73 m2: Use is not recommended.
eGFR less than 30 mL/min/1.73 m2: Contraindicated

Liver Dose Adjustments

Not recommended in patients with hepatic impairment.

Dose Adjustments

Therapeutic drug monitoring/range: Steady-state plasma concentrations of metformin are achieved within 24 to 48 hours and are less than 1 mcg/mL; metformin levels greater than 5 mcg/mL have been implicated as the cause of lactic acidosis.

Iodinated Contrast Imaging Procedures:

RESTART: Renal function should be reevaluated 48 hours after the imaging procedure and if renal function is stable this drug may be restarted.

Precautions

US BOXED WARNING: LACTIC ACIDOSIS


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated

Other Comments

Administration advice:


Storage requirements:
Store at 20C to 25C (68F to 77F); excursions permitted between 15C and 30C (59F and 86F).

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.