Generic name: Cyclosporine Capsules, Modified [ SYE-kloe-spor-een ]
Brand names: Gengraf, Neoral
Drug class: Calcineurin inhibitors

Medically reviewed by Drugs.com. Last updated on Dec 4, 2023.

Uses of Cyclosporine Capsules, Modified:

• It is used to keep the body from harming the organ after an organ transplant.
• It is used to treat rheumatoid arthritis.
• It is used to treat psoriasis.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Cyclosporine Capsules, Modified?

For all patients taking cyclosporine capsules, modified:

• If you have an allergy to cyclosporine or any other part of cyclosporine capsules, modified.
• If you are allergic to cyclosporine capsules, modified; any part of cyclosporine capsules, modified; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Cancer, kidney problems, or high blood pressure.
• If you are taking any of these drugs: Aliskiren, amiloride, bosentan, dabigatran, orlistat, spironolactone, or triamterene.
• If you are breast-feeding or plan to breast-feed.

Psoriasis:

• If you have psoriasis and are using other treatments like other drugs or radiation.

This is not a list of all drugs or health problems that interact with cyclosporine capsules, modified.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take cyclosporine capsules, modified with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cyclosporine Capsules, Modified?

• Tell all of your health care providers that you take cyclosporine capsules, modified. This includes your doctors, nurses, pharmacists, and dentists.
• If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
• If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
• This medicine has alcohol in it. Talk with the doctor.
• This medicine interacts with many other drugs. The chance of cyclosporine capsules, modified's side effects may be raised or how well cyclosporine capsules, modified works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take cyclosporine capsules, modified with all of your other drugs (prescription or OTC, natural products, vitamins).
• The chance of skin cancer may be raised. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• Have your skin checked as you have been told by your doctor.
• Some people treated with cyclosporine capsules, modified have had very bad kidney problems caused by a certain viral infection (BK virus). In people who have had a kidney transplant, BK virus infection may cause loss of the kidney. Call your doctor right away if you have signs of kidney problems like change in the amount of urine passed, difficulty or pain when passing urine, or blood in the urine.
• A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with cyclosporine capsules, modified. Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
• Talk with your doctor before getting any vaccines. Use of some vaccines with cyclosporine capsules, modified may either raise the chance of an infection or make the vaccine not work as well.
• Take good care of your teeth. See a dentist often.
• Avoid grapefruit and grapefruit juice.
• Watch for gout attacks.
• If you are 65 or older, use cyclosporine capsules, modified with care. You could have more side effects.
• Use with care in children. Talk with the doctor.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking cyclosporine capsules, modified, call your doctor right away.

How is this medicine (Cyclosporine Capsules, Modified) best taken?

Use cyclosporine capsules, modified as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food but take the same way each time. Always take with food or always take on an empty stomach.
• If you are taking sirolimus, take it 4 hours after taking cyclosporine capsules, modified.
• Keep taking cyclosporine capsules, modified as you have been told by your doctor or other health care provider, even if you feel well.
• Take cyclosporine capsules, modified at the same time of day.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
• Any unexplained bruising or bleeding.
• Feeling very tired or weak.
• A burning, numbness, or tingling feeling that is not normal.
• Chest pain or pressure or a fast heartbeat.
• Gum changes.
• Hearing loss.
• Shortness of breath.
• Shakiness.
• Swelling.
• Very bad and sometimes deadly liver problems have happened with cyclosporine capsules, modified. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with cyclosporine capsules, modified. It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

Related/similar drugs

methotrexate, hydroxychloroquine, Humira, tacrolimus, azathioprine, mycophenolate mofetil, cyclosporine, adalimumab, Enbrel, Remicade

What are some other side effects of Cyclosporine Capsules, Modified?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Stomach pain or diarrhea.
• Upset stomach or throwing up.
• Hair growth.
• Pimples (acne).
• Dizziness.
• Flushing.
• Signs of a common cold.
• Joint pain.
• Leg cramps.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Cyclosporine Capsules, Modified?

• Store in the original container at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about cyclosporine capsules, modified, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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