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Cabometyx

Generic Name: Cabozantinib Tablets (ka boe ZAN ti nib)
Brand Name: Cabometyx

Medically reviewed by Drugs.com. Last updated on Mar 14, 2019.

Warning

  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with Cabometyx (cabozantinib tablets). Talk with the doctor.
  • Very bad and sometimes deadly bleeding problems have happened with Cabometyx (cabozantinib tablets). Talk with the doctor.
  • If you have bleeding problems, talk with your doctor.
  • Call your doctor right away if you have any signs of bleeding problems, like bruising; black, tarry, or bloody stools; bleeding gums; blood in the urine; coughing up blood; cuts that take a long time to stop bleeding; feel dizzy; feeling very tired or weak; nosebleeds; pain or swelling; throwing up blood or throw up that looks like coffee grounds; or very bad headache.

Uses of Cabometyx:

  • It is used to treat cancer.

What do I need to tell my doctor BEFORE I take Cabometyx?

  • If you have an allergy to cabozantinib or any other part of Cabometyx (cabozantinib tablets).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have active bleeding or you are at risk for very bad bleeding.
  • If you have had recent bleeding or coughing up blood.
  • If you have any of these health problems: High blood pressure or liver disease.
  • If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with Cabometyx (cabozantinib tablets), like certain drugs that are used for HIV, infections, or seizures.
  • If you are taking St. John's wort. Do not take St. John's wort with Cabometyx (cabozantinib tablets). This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take Cabometyx (cabozantinib tablets) or for 4 months after your last dose.

This is not a list of all drugs or health problems that interact with Cabometyx (cabozantinib tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Cabometyx (cabozantinib tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cabometyx?

  • Tell all of your health care providers that you take Cabometyx (cabozantinib tablets). This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine may affect how wounds heal. If you need to have surgery, you may need to stop Cabometyx (cabozantinib tablets) before surgery. Start taking it again after surgery as you have been told by your doctor. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High blood pressure has happened with Cabometyx (cabozantinib tablets). Have your blood pressure checked as you have been told by your doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • It is common to have diarrhea, upset stomach, throwing up, or stomach pain with Cabometyx (cabozantinib tablets). Call your doctor if any of these side effects get very bad, bother you, or do not go away.
  • Avoid grapefruit and grapefruit juice.
  • Do not switch between different forms of Cabometyx (cabozantinib tablets) without first talking with the doctor.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with Cabometyx (cabozantinib tablets). Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
  • Blood clots have happened with Cabometyx (cabozantinib tablets). Sometimes, blood clots like stroke have been deadly. Call your doctor right away if you have chest, arm, back, neck, or jaw pain or pressure; coughing up blood; numbness or weakness on 1 side of your body, trouble speaking or thinking, change in balance, or change in eyesight; shortness of breath; or swelling, warmth, or pain in the leg or arm.
  • Very bad jaw problems have happened with Cabometyx (cabozantinib tablets). Have a dental exam before you start Cabometyx (cabozantinib tablets). Take good care of your teeth. Talk with your doctor.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Cabometyx (cabozantinib tablets). Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Cabometyx (cabozantinib tablets) and for 4 months after your last dose.
  • If you get pregnant while taking Cabometyx (cabozantinib tablets) or within 4 months after your last dose, call your doctor right away.

How is this medicine (Cabometyx) best taken?

Use Cabometyx (cabozantinib tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • Swallow whole. Do not chew, break, or crush.
  • Take with a full glass of water.
  • To gain the most benefit, do not miss doses.
  • Keep taking Cabometyx (cabozantinib tablets) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it and go back to your normal time.
  • If it is less than 12 hours until the next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of low thyroid levels like constipation; not able to handle cold; memory problems; mood changes; or a burning, numbness, or tingling feeling that is not normal.
  • Sweating a lot.
  • Trouble walking.
  • Shortness of breath.
  • Coughing, gagging, or choking (mainly when eating or drinking).
  • Skin wound that will not heal.
  • Jaw pain.
  • Very bad mouth irritation.
  • Mouth sores.
  • Not able to pass urine or change in how much urine is passed.
  • Redness or irritation of the palms of hands or soles of feet.
  • Swelling in the arms or legs.
  • A burning, numbness, or tingling feeling that is not normal.
  • Low blood cell counts have happened with Cabometyx (cabozantinib tablets). If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.

What are some other side effects of Cabometyx?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Not hungry.
  • Weight loss.
  • Constipation.
  • Mouth irritation.
  • Change in taste.
  • Headache.
  • Joint pain.
  • Muscle spasm.
  • Dizziness.
  • Change in voice.
  • Dry skin.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Cabometyx?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Cabometyx (cabozantinib tablets), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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