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Aspirin and Omeprazole

Generic Name: Aspirin and Omeprazole (AS pir in & oh MEP ra zole)
Brand Name: Yosprala

Medically reviewed by Drugs.com. Last updated on Aug 1, 2019.

Uses of Aspirin and Omeprazole:

  • It is used to lower the chance of heart attack, stroke, and death in some people.

What do I need to tell my doctor BEFORE I take Aspirin and Omeprazole?

For all patients taking aspirin and omeprazole:

  • If you have an allergy to aspirin and omeprazole or any part of aspirin and omeprazole.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Asthma, bleeding problems, nose polyps, or nose irritation.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you are having trouble getting pregnant or you are having your fertility checked.
  • If you are pregnant or may be pregnant. Do not take aspirin and omeprazole if you are in the third trimester of pregnancy. You may also need to avoid aspirin and omeprazole at other times during pregnancy. Talk with your doctor to see when you need to avoid taking aspirin and omeprazole during pregnancy.
  • If you are breast-feeding. Do not breast-feed while you take aspirin and omeprazole.
  • If you are taking any of these drugs: Atazanavir, clopidogrel, nelfinavir, rifampin, rilpivirine, St. John's wort, ticagrelor, or voriconazole.
  • If you are taking another drug that has the same drug in it.
  • If you are taking any other NSAID.

Children:

  • If your child or teenager has or is getting better from flu signs, chickenpox, or other viral infections. The risk of a very bad problem called Reye's syndrome may be raised. Do not give aspirin and omeprazole to a child or teenager who has or is getting better from a viral infection.

This is not a list of all drugs or health problems that interact with aspirin and omeprazole.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take aspirin and omeprazole with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Aspirin and Omeprazole?

  • Tell all of your health care providers that you take aspirin and omeprazole. This includes your doctors, nurses, pharmacists, and dentists.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • This medicine may raise the chance of severe and sometimes deadly stomach or bowel problems like ulcers or bleeding. The risk is greater in older people, and in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take aspirin and omeprazole.
  • This medicine may raise the chance of hip, spine, and wrist fractures in people with weak bones (osteoporosis). The chance may be higher if you take aspirin and omeprazole in high doses or for longer than a year, or if you are older than 50 years old.
  • Rarely, low magnesium levels have happened in people taking drugs like this one for at least 3 months. Most of the time, this happened after 1 year of treatment. You will need to have blood work if you take aspirin and omeprazole for a long time or with certain other drugs.
  • Rarely, long-term treatment (for instance longer than 3 years) with drugs like this one has caused low vitamin B-12 levels. Call your doctor right away if you have signs of low vitamin B-12 levels like shortness of breath, dizziness, abnormal heartbeat, muscle weakness, pale skin, tiredness, mood changes, or numbness or tingling in the arms or legs.
  • Lupus has happened with aspirin and omeprazole, as well as lupus that has gotten worse in people who already have it. Tell your doctor if you have lupus. Call your doctor right away if you have signs of lupus like a rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
  • Very bad pancreas, liver, and white blood cell problems have happened in people who were taking aspirin and omeprazole. Rarely, these have been fatal. Talk with the doctor if you have questions.
  • This medicine may raise the chance of a severe form of diarrhea called C diff-associated diarrhea (CDAD). Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat diarrhea without first checking with your doctor.
  • If you are of Asian descent, use aspirin and omeprazole with care. You could have more side effects.
  • NSAIDs like aspirin and omeprazole may affect egg release (ovulation) in women. This may cause you to not be able to get pregnant. This goes back to normal when aspirin and omeprazole is stopped. Talk with your doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking aspirin and omeprazole, call your doctor right away.

How is this medicine (Aspirin and Omeprazole) best taken?

Use aspirin and omeprazole as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take aspirin and omeprazole at least 60 minutes before a meal.
  • Swallow whole with a full glass of water.
  • Do not chew, break, or crush.
  • Keep taking aspirin and omeprazole as you have been told by your doctor or other health care provider, even if you feel well.
  • Do not take aspirin and omeprazole for longer than you were told by your doctor.
  • Do not stop taking aspirin and omeprazole all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop aspirin and omeprazole, you will want to slowly stop it as ordered by your doctor.
  • Do not use aspirin and omeprazole for sudden signs of a heart attack or stroke. Talk with your doctor about what to do if these signs happen to you.
  • Talk with your doctor before you drink alcohol.
  • Use care if you have risks for soft, brittle bones (osteoporosis). Some of these risks include drinking alcohol, smoking, taking steroids, taking drugs to treat seizures, or having family members with osteoporosis. Talk with your doctor about your risks of osteoporosis.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses unless told to do so by your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of low magnesium levels like mood changes, muscle pain or weakness, muscle cramps or spasms, seizures, shakiness, not hungry, very bad upset stomach or throwing up, or a heartbeat that does not feel normal.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Bone pain.
  • Swelling.
  • Very bad dizziness or passing out.
  • Ringing in ears.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Aspirin and Omeprazole?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Belly pain or heartburn.
  • Upset stomach or throwing up.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Aspirin and Omeprazole?

  • Store in the original container at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep lid tightly closed.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time aspirin and omeprazole is refilled. If you have any questions about aspirin and omeprazole, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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