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Amitriptyline and Perphenazine

Generic Name: Amitriptyline and Perphenazine (a mee TRIP ti leen & per FEN a zeen)

Medically reviewed on July 4, 2018

Warning

  • Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take amitriptyline and perphenazine need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • This medicine is not approved for use in children. Talk with the doctor.
  • There is a higher chance of death in older adults who take amitriptyline and perphenazine for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This medicine is not approved to treat mental problems caused by dementia.

Uses of Amitriptyline and Perphenazine:

  • It is used to treat low mood (depression).
  • It is used to treat anxiety.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Amitriptyline and Perphenazine?

  • If you have an allergy to amitriptyline, perphenazine, or any other part of amitriptyline and perphenazine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Bone marrow disease or recent heart attack.
  • If you have recently drunk a lot of alcohol or taken a big amount of drugs that may slow your actions like phenobarbital or some pain drugs like oxycodone.
  • If you are taking guanethidine.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking amitriptyline and perphenazine within 14 days of those drugs can cause very bad high blood pressure.
  • If you are breast-feeding. Do not breast-feed while you take amitriptyline and perphenazine.

This is not a list of all drugs or health problems that interact with amitriptyline and perphenazine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take amitriptyline and perphenazine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Amitriptyline and Perphenazine?

  • Tell all of your health care providers that you take amitriptyline and perphenazine. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how amitriptyline and perphenazine affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Avoid drinking alcohol while taking amitriptyline and perphenazine.
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take amitriptyline and perphenazine.
  • This medicine may cause the results of some pregnancy tests to be wrong. Talk with the doctor.
  • Some people may have a higher chance of eye problems with amitriptyline and perphenazine. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.
  • Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of getting an infection. Deadly infections have rarely happened. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Talk with your doctor.
  • A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Dizziness, sleepiness, and feeling less stable may happen with amitriptyline and perphenazine. These may lead to falling. Broken bones or other health problems can happen from falling. Talk with the doctor.
  • Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • If you are 65 or older, use amitriptyline and perphenazine with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using amitriptyline and perphenazine while you are pregnant.
  • Taking amitriptyline and perphenazine in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.

How is this medicine (Amitriptyline and Perphenazine) best taken?

Use amitriptyline and perphenazine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • To gain the most benefit, do not miss doses.
  • Keep taking amitriptyline and perphenazine as you have been told by your doctor or other health care provider, even if you feel well.
  • If you have been taking amitriptyline and perphenazine on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking amitriptyline and perphenazine all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Fast or slow heartbeat.
  • A heartbeat that does not feel normal.
  • Chest pain or pressure.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Shakiness, trouble moving around, or stiffness.
  • Not able to pass urine.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Swelling in the arms or legs.
  • Hallucinations (seeing or hearing things that are not there).
  • A burning, numbness, or tingling feeling that is not normal.
  • Drooling.
  • Seizures.
  • Pale skin.
  • Very bad belly pain.
  • Very hard stools (constipation).
  • Not sweating during activities or in warm temperatures.
  • Swelling of the testicles.
  • Enlarged breasts.
  • Nipple discharge.
  • Change in sex interest.
  • Not able to get or keep an erection.
  • For women, no period.
  • Some people who take amitriptyline and perphenazine may get a very bad muscle problem called tardive dyskinesia. This muscle problem may not go away even if amitriptyline and perphenazine is stopped. Sometimes, signs may lessen or go away over time after amitriptyline and perphenazine is stopped. The risk of tardive dyskinesia may be greater in people with diabetes and in older adults, especially older women. The risk is also greater the longer you take amitriptyline and perphenazine or with higher doses. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.

What are some other side effects of Amitriptyline and Perphenazine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Feeling nervous and excitable.
  • Feeling tired or weak.
  • Hard stools (constipation).
  • Upset stomach or throwing up.
  • Not hungry.
  • Dry mouth.
  • Not able to sleep.
  • Headache.
  • Dizziness.
  • Loose stools (diarrhea).
  • Stuffy nose.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Amitriptyline and Perphenazine?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time amitriptyline and perphenazine is refilled. If you have any questions about amitriptyline and perphenazine, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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