Skip to main content

How fast does Latuda work?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on July 10, 2024.

Official Answer by Drugs.com

Latuda (generic name: lurasidone) works in most patients within 6 weeks or sooner at an appropriate dose, although results can vary between patients. Latuda is an atypical antipsychotic approved for patients with schizophrenia or bipolar depression. Some patients may respond as early as 1 to 3 weeks; however, some patients may not respond at all or have side effects that interrupt treatment.

It is important that you take your Latuda with food that contains at least 350 calories. Taking Latuda with food will greatly help to increase the absorption of the medicine into your body. Better absorption can increase the effectiveness of Latuda.

In randomized, placebo-controlled clinical studies conducted by the manufacturer in patients with either schizophrenia or bipolar depression, significant results of the primary endpoint were seen at 6 weeks in various age groups.

Latuda is approved in the U.S. for the treatment of:

The effectiveness of Latuda for longer than 6 weeks has not been evaluated in controlled clinical studies. However, your doctor will periodically reevaluate your response to the long-term use of Latuda if you remain on treatment for longer than 6 weeks.

Schizophrenia

Latuda is an oral prescription medicine that is given once a day. It can help keep the symptoms of schizophrenia under control in people 13 years of age or older.

Latuda was evaluated in many studies of adults living with schizophrenia and in one study of adolescents 13–17 years of age. These studies looked at how well Latuda works, how safe it is, and how well people tolerated it.

Bipolar depression (depressive episode associated with bipolar I disorder)

Latuda has been studied in 6-week studies in adult patients with bipolar depression using it as monotherapy (used alone) or in combination with other agents such as lithium or valproate.

In children and adolescents 10 to 17 years of age with bipolar depression, Latuda was associated with statistically significant and clinically meaningful improvement in bipolar depression symptoms compared to placebo in 6-week studies.

To learn more about Latuda dosing in adults and children, visit: Latuda Dosing

Related questions

Bottom Line

This is not all the information you need to know about Latuda for safe and effective use. Review the full Latuda prescribing information here, and discuss this information with your doctor or other health care provider.

References
  • Latuda (lurasidone) [prescribing information]. Sunovion Pharmaceuticals Inc. December 2019. Accessed July 20, 2020 at https://www.latuda.com/LatudaPrescribingInformation.pdf
  • Loebel A, Cucchiaro J, Silva S, et al. Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2013;171(2):160-168.
  • DelBello MP, Goldman R, Phillips D, et al. Efficacy and safety of lurasidone in children and adolescents with bipolar I depression: a double-blind, placebo-controlled study. J Am Acad Child Adolesc Psychiatry. 2017;56(12):1015-1025.
  • Loebel A, Cucchiaro J, Silva S, et al. Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2013;171(2):169-177.
  • Meltzer HY, Cucchiaro J, Silva R, et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry. 2011;168:957-967.
  • Goldman R, Loebel A, Cucchiaro J, Deng L, Findling RL. Efficacy and safety of lurasidone in adolescents with schizophrenia: a 6-week, randomized placebo-controlled study. J Child Adolesc Psychopharmacol. 2017;27:1-10.

Read next

Does Latuda cause weight gain?

Latuda has a low risk for weight gain in adults and children with schizophrenia or bipolar depression, but this can vary in individual patients. In general, Latuda caused minimal weight gain either in the short-term or the longer-term studies conducted by the manufacturer. Continue reading

Can Latuda be cut in half or split?

Latuda should NOT be cut in half or split, according to the manufacturer. It comes in various strengths to allow your doctor to prescribe the correct dose. Continue reading

Is Latuda a controlled substance?

No, Latuda (an atypical antipsychotic) is not classified as a controlled substance by the U.S. Drug Enforcement Agency (DEA). None of the atypical antipsychotics in the U.S. are classified as a controlled substance. Continue reading

Related medical questions

Drug information

Related support groups