Why do you have to avoid grapefruit when taking Latuda?
Grapefruit contains organic compounds called furanocoumarins that block an enzyme called CYP3A4 that normally breaks down Latuda and certain other medications. When this enzyme is blocked, levels of Latuda in the blood will be higher than expected, and the intended effect or side effects of the drug will be stronger, even dangerous. People taking Latuda should avoid grapefruit, grapefruit juice, and products containing grapefruit (such as marmalade) because taking them together may increase the risk of side effects such as Parkinson-like symptoms, diabetes, headache, drowsiness, dizziness, or other effects.
Other citrus fruits such as pomelos, limes, and Seville oranges also contain furanocoumarins, and they may also interact with Latuda, but they haven't been studied as closely.
References
- Latuda (lurasidone hydrochloride). Reviewed 11/2020. Sunovion Pharmaceuticals Inc. https://www.drugs.com/pro/latuda.html
- Latuda (lurasidone). Latuda.com https://www.latuda.com/
- Tsai, J., Thase, M., Mao, Y., Ng-Mak, D., Pikalov, A., & Loebel, A. (2017). Lurasidone for major depressive disorder with mixed features and anxiety: A post-hoc analysis of a randomized, placebo-controlled study. CNS
Read next
Can you stop taking Latuda immediately?
Talk to your doctor before stopping Latuda (lurasidone) or adjusting your dose, even if you feel better after starting treatment. If you stop taking Latuda, your symptoms can worsen or you may suffer from unwanted side effects. Always take Latuda exactly as prescribed by your doctor. Continue reading
Does Latuda make you sleepy?
Yes, Latuda (generic name: lurasidone) can cause drowsiness and make you feel sleepy. Drowsiness (somnolence) is one of the most common side effects that patients experience with Latuda. Continue reading
Is Latuda a mood stabilizer or an antipsychotic?
Latuda (lurasidone) is classified as an atypical antipsychotic and is approved for treatment of patients with either schizophrenia and bipolar depression. Latuda can be used alone or in combination with the mood stabilizers lithium or valproate to treat bipolar depression. Continue reading
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