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Generic Name: tenofovir disoproxil fumarate
Brand Names: Viread

What is Viread?

Viread (tenofovir disoproxil fumarate) is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B from multiplying in your body.

Viread is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Viread is not a cure for HIV or AIDS.

Viread is also used to treat chronic hepatitis B infection in adult subjects and children 12 years of age and older with compensated liver disease.

Important information

Do not take Viread together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Complera, Genvoya, Odefsey, Stribild, or Truvada).

If you have ever had chronic hepatitis B, Viread can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function.

Do not stop using tenofovir disoproxil without first talking to your healthcare providers.

This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Viread can also cause severe or life-threatening effects on your liver. Call your doctor at once if you have: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Before taking this medicine

You should not take Viread if you are allergic to tenofovir.

Do not take Viread together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Complera, Genvoya, Odefsey, Stribild, or Truvada).

Viread should not be given to a child with HIV who is younger than 2 years old. Tenofovir disoproxil should not be used to treat chronic hepatitis B in a child younger than 12 years old.

To make sure this medicine is safe for you, tell your doctor if you have:

  • liver disease (especially hepatitis B if you also have HIV);

  • kidney disease; or

  • low bone mineral density.

Some people taking Viread develop a serious condition called lactic acidosis. This may be more likely in women, in people who are overweight or have liver disease, and in people who have taken HIV/AIDS medication for a long time. Talk with your doctor about your risk.

This medication is not expected to be harmful to an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV treatment medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of tenofovir on the baby.

Tenofovir can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Viread to treat hepatitis B. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Viread?

Before you start receiving treatment with Viread, your doctor may perform tests to make sure you do not have HIV (if you are being treated for hepatitis B) or hepatitis B (if you are receiving HIV treatment).

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Viread tablets may be taken with or without food. Take the medicine at the same time each day.

Viread oral powder should be mixed with food such as applesauce, yogurt, or baby food. Do not mix the oral powder with liquid.

If a child is taking this medication, tell your doctor if the child has any changes in weight. The recommended dose of tenofovir is based on weight in children.

While using Viread, you may need frequent blood tests. Your liver and kidney function may also need to be checked.

Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop using Viread without first talking to your doctor.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your recommended dose or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

If you have hepatitis B you may develop liver symptoms after you stop taking this medication, even months after stopping. Your doctor may want to check your liver function for several months after you stop using Viread. Visit your doctor regularly.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Viread?

Avoid drinking alcohol. It may increase your risk of liver damage.

Taking this medicine will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Viread side effects

Get emergency medical help if you have any signs of an allergic reaction to Viread: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Call your doctor or healthcare providers at once if you have:

  • sore throat, flu symptoms, easy bruising or unusual bleeding;

  • kidney problems - little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or

  • liver problems - swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Viread may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Viread. Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  • trouble speaking or swallowing, severe lower back pain, bone pain, knee pain, loss of bladder or bowel control; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Common Viread side effects may include:

  • stomach pain, nausea, vomiting, diarrhea;

  • fever, pain, cough;

  • weakness, dizziness, feeling tired;

  • headache, back pain;

  • depressed mood;

  • sleep problems (insomnia);

  • itching or rash; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor or healthcare providers for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Viread?

Viread can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Tell your doctor or healthcare providers about all your current medicines and any you start or stop using, especially:

  • atazanavir (Reyataz);

  • darunavir (Prezista);

  • didanosine (Videx);

  • ledipasvir and sofosbuvir (Harvoni); or

  • lopinavir and ritonavir (Kaletra).

This list is not complete. Other drugs may interact with tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Viread is manufactured by Gilead Sciences, Inc. Your pharmacist can provide more information about this medicine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Viread only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare providers and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your healthcare providers, doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 11.01. Revision Date: 2017-07-11, 3:11:56 PM.

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