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Generic Name: tenofovir alafenamide
Brand Names: Vemlidy, Viread

Medically reviewed on Sep 3, 2018

What is Vemlidy?

Vemlidy (tenofovir alafenamide) is an antiviral medicine that prevents the hepatitis B virus from multiplying in your body.

Vemlidy is used to treat patients with chronic hepatitis B infection in adults with compensated liver disease.

Tenofovir alafenamide (Vemlidy) is used to treat patients with chronic hepatitis B. Tenofovir disoproxil (Viread) is used to treat HIV-1 infection and chronic hepatitis B.

Important Information

If you have hepatitis B, it may become active or get worse after you stop using Vemlidy. You may need frequent liver function tests for several months.

Do not stop using Vemlidy without first talking to your doctor. If you have ever had hepatitis B, stopping treatment with tenofovir can cause acute exacerbations of hepatitis B. You will need frequent blood tests to check your liver function.

Do not take tenofovir alafenamide together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Biktarvy, Cimduo, Complera, Descovy, Genvoya, Odefsey, Stribild, Symfi, or Truvada).

Vemlidy is not recommended in patients with end stage renal disease.

Before taking this medicine

You should not take Vemlidy if you are allergic to tenofovir alafenamide.

Do not take this medicine together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Complera, Descovy, Genvoya, Odefsey, Stribild, or Truvada).

Vemlidy should not be used to treat patients with chronic hepatitis B in a child younger than 18 years old.

Tell your doctor if you have ever had:

  • liver disease (especially hepatitis B if you also have HIV);

  • kidney disease; or

  • low bone mineral density.

Some people taking Vemlidy develop a serious condition called lactic acidosis. This may be more likely in women, in people who are overweight or have liver disease, and in people who have taken medication similar to tenofovir for a long time. Talk with your doctor about your risk.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of tenofovir on the baby.

Tenofovir alafenamide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using tenofovir alafenamide to treat hepatitis B.

How should I take Vemlidy?

Before you start treatment with Vemlidy, your doctor may perform tests to make sure you do not have HIV (if you are being treated for hepatitis B).

Take this medicine at the same time each day. Carefully follow all instructions on your medicine label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Vemlidy should be taken with food.

The recommended dose is one 25mg Vemlidy tablet taken by mouth once a day.

Do not stop using this medicine without first talking to your doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

If you have hepatitis B, this virus may become active or get worse in the months after you stop using Vemlidy. You may need frequent liver function tests while using this medicine and for several months after your last dose.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Vemlidy?

Avoid drinking alcohol. It may increase your risk of liver damage.

Taking this medicine will not prevent you from passing hepatitis B to other people.

Vemlidy side effects

Get emergency medical help if you have signs of an allergic reaction to Vemlidy: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

  • sore throat, flu symptoms, easy bruising or unusual bleeding;

  • kidney problems - little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or

  • liver problems - swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Tenofovir alafenamide affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Vemlidy side effects may include:

  • stomach pain, nausea, vomiting, diarrhea;

  • fever, pain, cough;

  • weakness, dizziness, feeling tired;

  • headache, back pain;

  • depressed mood;

  • sleep problems (insomnia);

  • itching or rash; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vemlidy?

Vemlidy can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with tenofovir alafenamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vemlidy only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.