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Vioxx

Generic name: rofecoxib (oral) [ row-feh-COCK-sib ]
Drug class: Cox-2 inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 14, 2023.

What is the most important information I should know about Vioxx?

Vioxx was withdrawn from the U.S. market in 2004.

The manufacturer of Vioxx has announced a voluntary withdrawal of the drug from the U.S. and worldwide market. This withdrawal is due to safety concerns of an increased risk of cardiovascular events (including heart attack and stroke) in patients taking Vioxx.

Notify your doctor immediately if you develop abdominal pain, tenderness, or discomfort; nausea; blood in your vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of your skin or eyes;"flu-like" symptoms; or unusual bruising or bleeding. These symptoms could be early signs of dangerous side effects.

What is Vioxx?

Vioxx was withdrawn from the U.S. market in 2004.

Vioxx is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Vioxx works by reducing substances that cause inflammation, pain, and fever in the body.

Vioxx is used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis and certain forms of juvenile rheumatoid arthritis; to manage acute pain in adults; to treat migraines; and to treat menstrual pain.

Vioxx may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Vioxx?

The manufacturer of Vioxx has announced a voluntary withdrawal of the drug from the U.S. and worldwide market. This withdrawal is due to safety concerns of an increased risk of cardiovascular events (including heart attack and stroke) in patients taking Vioxx.

Do not take Vioxx without first talking to your doctor if you have experienced asthma, hives, or an allergic reaction after taking aspirin or another NSAID such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen (Orudis KT, Orudis, Oruvail), diclofenac (Voltaren, Cataflam), diflunisal (Dolobid), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), celecoxib (Celebrex), valdecoxib (Bextra), or meloxicam (Mobic). You may experience a similar reaction to Vioxx.

Before taking Vioxx, tell your doctor if you

You may not be able to take Vioxx, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions, or are taking any of the medicines, listed above.

Vioxx is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Vioxx should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart. Do not take Vioxx without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Vioxx passes into breast milk. Do not take Vioxx without first talking to your doctor if you are breast-feeding. If you are over the age of 65 years, you may be more likely to experience side effects from Vioxx. You may require a lower dosage or special monitoring during treatment.

How should I take Vioxx?

Take Vioxx exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Shake the Vioxx suspension well before measuring a dose. Use a dose-measuring cup or spoon, not a regular table spoon, to measure the liquid form of Vioxx to ensure that you measure the correct amount of medicine. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Vioxx can be taken with or without food or milk.

Store Vioxx at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless your doctor directs otherwise.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a Vioxx overdose are not known.

What should I avoid?

There are no restrictions on food, beverages, or activity during treatment with Vioxx, unless otherwise directed by your doctor.

What are the possible side effects of Vioxx?

Notify your doctor immediately if you develop abdominal pain, tenderness, or discomfort; nausea; blood in your vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of your skin or eyes;"flu-like" symptoms; or unusual bruising or bleeding. These symptoms could be early signs of dangerous side effects.

If you experience any of the following serious side effects, stop taking Vioxx and seek medical treatment or contact your doctor immediately:

Other, less serious side effects may be more likely to occur. Continue to take Vioxx and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Vioxx?

Before taking Vioxx, tell your doctor if you are taking any of the following drugs:

You may not be able to take an Vioxx, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Vioxx. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Copyright 1996-2024 Cerner Multum, Inc. Version: 8.01.

References

  1. Vioxx Product Label

Further information

What does my medication look like?

Vioxx was withdrawn from the U.S. market in 2004.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.