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Trijardy XR

Generic Name: empagliflozin, linagliptin, and metformin (EM pa gli FLOE zin, LIN a GLIP tin, and met FOR min)
Brand Names: Trijardy XR

Medically reviewed by Judith Stewart, BPharm Last updated on May 15, 2020.

What is Trijardy XR?

Trijardy XR contains a comination of empagliflozin, linagliptin, and metformin. Empagliflozin, linagliptin, and metformin are all oral diabetes medicines that help control blood sugar levels.

Trijardy XR medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Trijardy XR is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Trijardy XR is not for treating type 1 diabetes.

Important Information

You should not use Trijardy XR if you have severe kidney disease (or if you are on dialysis) or diabetic ketoacidosis, or if you have ever had a severe allergic reaction to empagliflozin or linagliptin.

Call your doctor at once if you have signs of a serious side effect, such as severe pain in your upper stomach spreading to your back, vomiting, fast heart rate, dizziness, feeling very thirsty or hot, decreased urination, heavy sweating, or hot and dry skin.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

In rare cases, Trijardy XR can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

Before taking this medicine

You should not use Trijardy XR if you are allergic to empagliflozin, linagliptin, or metformin, or if you have:

  • severe kidney disease (or if you are on dialysis);

  • a history of severe allergic or skin reaction after taking linagliptin; or

  • metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Trijardy XR. Be sure your caregivers know ahead of time that you are using this medication.

To make sure Trijardy XR is safe for you, tell your doctor if you have:

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using Trijardy XR if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using Trijardy XR.

How should I take Trijardy XR?

Take Trijardy XR exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Trijardy XR is usually taken in the morning with a meal.

Swallow the Trijardy XR tablet whole and do not crush, chew, break, or dissolve it. Tell your doctor if you have trouble swallowing the tablet.

Tell your doctor if you notice a Trijardy XR tablet in your stool that was not absorbed or melted in the body. Your blood sugar levels may need to be checked to be sure Trijardy XR is working well.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Empagliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Trijardy XR can affect the results of certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Trijardy XR.

Store at room temperature away from moisture and heat.

Your doctor may have you take extra vitamin B12 while you are taking Trijardy XR. Take only the amount of vitamin B12 your doctor has prescribed.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause life threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What should I avoid while taking Trijardy XR?

Avoid drinking alcohol. It may increase your risk of lactic acidosis.

Trijardy XR side effects

Get emergency medical help if you have signs of an allergic reaction to Trijardy XR: hives, itching, flaking or peeling skin; trouble swallowing, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a rare but serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Stop taking Trijardy XR and call your doctor at once if you have:

  • severe or ongoing pain in your joints;

  • lactic acidosis - unusual muscle pain, trouble breathing, stomach pain, vomiting, slow or irregular heart rate, dizziness, feeling cold, or feeling very weak or tired;

  • serious skin reaction - itching, blisters, breakdown of the outer layer of skin;

  • ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;

  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  • dehydration symptoms - dizziness, weakness, feeling light-headed (like you might pass out);

  • signs of a bladder infection - pain or burning when you urinate, blood in your urine, pain in pelvis or back; or

  • symptoms of heart failure - shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Common Trijardy XR side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trijardy XR?

Other drugs may increase or decrease the effects of Trijardy XR on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with empagliflozin, linagliptin, and metformin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trijardy XR only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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