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Zylet Side Effects

Generic name: loteprednol / tobramycin ophthalmic

Medically reviewed by Last updated on Mar 6, 2023.

Note: This document contains side effect information about loteprednol / tobramycin ophthalmic. Some dosage forms listed on this page may not apply to the brand name Zylet.

Applies to loteprednol/tobramycin ophthalmic: ophthalmic suspension.

Serious side effects of Zylet

Along with its needed effects, loteprednol/tobramycin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking loteprednol / tobramycin ophthalmic:

More common

  • Blurred vision
  • change in vision
  • feeling like something is in the eye
  • increased pressure in the eye
  • loss of vision
  • pain or irritation of the clear front part of the eye
  • sensitivity of the eyes to light

Less common

  • Blurred vision or seeing blue-green halos around objects
  • chest tightness
  • decreased vision
  • difficulty seeing at night
  • discharge from the eye
  • dry eyes
  • eyelid burning, redness, itching, pain, or tenderness
  • fast heartbeat
  • fever
  • hives, itching, skin rash
  • hoarseness
  • irritation and swelling of the eye
  • joint pain
  • lid itching and swelling
  • pain in the eye
  • redness of the eyelid
  • redness of the skin
  • stiffness or swelling
  • swelling of the eyelids, face, lips, hands, or feet
  • trouble breathing or swallowing

Incidence not known

  • Redness of the eye
  • tearing

Other side effects of Zylet

Some side effects of loteprednol / tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning of the eye
  • headache
  • increased sensitivity of the eyes to light
  • stinging of the eye

For Healthcare Professionals

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension.


Very common (10% or more): Injection (20%), superficial punctuate keratitis (15%), intraocular pressure increased (10%)

Frequency not reported: Vision disorder, discharge, itching, lacrimation disorder, photophobia, corneal deposit, ocular discomfort, eyelid disorder, unspecified eye disorder

Loteprednol etabonate:

Frequency not reported: Intraocular pressure increased, visual acuity defect, field defect, posterior subcapsular cataract formation, delayed wound healing, secondary ocular infection


Frequency not reported: Lid itching, conjunctival erythema, lid swelling[Ref]

Nervous system

Very common (10% or more): Headache (14%)[Ref]



Frequency not reported: Hypersensitivity[Ref]


The most frequently reported side effects were injections and superficial punctate keratitis, increased intraocular pressure, and burning and stinging upon instillation.[Ref]


Common (1% to 10%): Burning, stinging


Frequency not reported: Localized ocular toxicity[Ref]


1. Product Information. Zylet (loteprednol-tobramycin ophthalmic). Bausch and Lomb Americas, Inc. 2005.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.