Skip to Content

Zylet Side Effects

Generic Name: loteprednol / tobramycin ophthalmic

Note: This document contains side effect information about loteprednol / tobramycin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Zylet.

For the Consumer

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension

Along with its needed effects, loteprednol / tobramycin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking loteprednol / tobramycin ophthalmic:

More common
  • Blurred vision
  • change in vision
  • feeling like something is in the eye
  • increased intraocular pressure
  • loss of vision
  • pain or irritation of the clear front part of the eye
  • sensitivity of the eyes to light
Less common
  • Blurred vision or seeing blue-green halos around objects
  • decreased vision
  • difficulty seeing at night
  • discharge from the eye
  • dry eyes
  • eyelid burning, redness, itching, pain, or tenderness
  • fast heartbeat
  • fever
  • hives
  • hoarseness
  • irritation and swelling of the eye
  • itching
  • joint pain
  • lid itching and swelling
  • pain in the eye
  • rash
  • redness of the eyelid
  • redness of the skin
  • shortness of breath
  • stiffness or swelling
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • wheezing
Incidence not known
  • Redness of the eye
  • tearing

Some side effects of loteprednol / tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning of the eye
  • headache
  • increased sensitivity of the eyes to light
  • stinging of the eye

For Healthcare Professionals

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension

Ocular

Very common (10% or more): Injection (20%), superficial punctuate keratitis (15%), intraocular pressure increased (10%)
Frequency not reported: Vision disorder, discharge, itching, lacrimation disorder, photophobia, corneal deposit, ocular discomfort, eyelid disorder, unspecified eye disorder

Loteprednol etabonate:
Frequency not reported: Intraocular pressure increased, visual acuity defect, field defect, posterior subcapsular cataract formation, delayed wound healing, secondary ocular infection

Tobramycin:
Frequency not reported: Lid itching, conjunctival erythema, lid swelling[Ref]

Nervous system

Very common (10% or more): Headache (14%)[Ref]

Hypersensitivity

Tobramycin:
Frequency not reported: Hypersensitivity[Ref]

General

The most frequently reported side effects were injections and superficial punctate keratitis, increased intraocular pressure, and burning and stinging upon instillation.[Ref]

Local

Common (1% to 10%): Burning, stinging

Tobramycin:
Frequency not reported: Localized ocular toxicity[Ref]

References

1. "Product Information. Zylet (loteprednol-tobramycin ophthalmic)." Bausch and Lomb, Rochester, NY.

Some side effects of Zylet may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide