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Generic name: loteprednol and tobramycin ophthalmicLOE-te-PRED-nol-and-TOE-bra-MYE-sin-off-THAL-mik ]
Drug class: Ophthalmic steroids with anti-infectives

Medically reviewed by Last updated on Jul 31, 2023.

What are Zylet eye drops?

Zylet eye drops contain a combination of loteprednol and tobramycin. Loteprednol is a steroid. It prevents the release of substances in the body that cause inflammation. Tobramycin is an antibiotic that fights bacteria.

Zylet eye drops are used to treat eye inflammation caused by surgery, infection, allergies, and other conditions.

Zylet may also be used for purposes not listed in this medication guide.


You should not use Zylet if you have any type of fungal, viral, or bacterial infection in your eye (including herpes or chickenpox).

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying Zylet. Ask your doctor if contact lenses can be reinserted after application of the medication. Zylet may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Before taking this medicine

You should not use Zylet if you are allergic to loteprednol or tobramycin, or other steroids. You should not use if you have any type of fungal, viral, or bacterial infection in your eye (including herpes or chickenpox).

To make sure Zylet is safe for you, tell your doctor if you have:

It is not known whether Zylet will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether loteprednol and tobramycin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give Zylet to a child younger than 6 years old without medical advice.

How should I use Zylet?

Use Zylet eye drops exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medicine while wearing contact lenses. This medicine may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Shake the eye drops well just before each use.

Wash your hands before using the eye drops.

To apply the eye drops:

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Call your doctor if your symptoms do not improve, or if they get worse while using Zylet.

If you use Zylet long-term, you may need frequent medical tests at your doctor's office.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of Zylet is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Zylet?

Do not use other eye medications unless your doctor tells you to.

This medicine may cause blurred vision and may impair your reactions. Be careful if you drive or do anything that requires you to be able to see clearly.

Zylet side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Zylet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

Common Zylet side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zylet?

It is not likely that other drugs you take orally or inject will have an effect on loteprednol and tobramycin used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.


  1. Zylet Product Label

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zylet only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.