Zetonna Side Effects

Generic name: ciclesonide nasal

Medically reviewed by Drugs.com. Last updated on Mar 15, 2025.

Note: This document provides detailed information about Zetonna Side Effects associated with ciclesonide nasal. Some dosage forms listed on this page may not apply specifically to the brand name Zetonna.

Applies to ciclesonide nasal: nasal aerosol liquid, nasal spray.

Serious side effects of Zetonna

Along with its needed effects, ciclesonide nasal (the active ingredient contained in Zetonna) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ciclesonide nasal:

Less common side effects

• bloody nose
• fever
• headache
• muscle aches
• nasal discomfort
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

Rare side effects

• acne or pimples
• blindness
• blistering, burning, crusting, dryness, or flaking of the skin
• bloody mucus or unexplained nosebleeds
• blurred vision
• change in vision
• darkening of the skin
• decreased vision
• diarrhea
• difficulty with breathing or troubled breathing
• difficulty with swallowing
• dizziness
• eye pain
• fainting
• hives
• itching, scaling, severe redness, soreness, or swelling of the skin
• loss of appetite
• loss of consciousness
• loss of vision
• menstrual changes
• mental depression
• nausea
• reddening of the skin, especially around the ears
• skin rash
• swelling of the eyes, eyelids, face, or inside of the nose
• tearing
• tightness in the chest
• vomiting
• weight gain around the face, neck, and trunk
• wheezing
• white patches inside the nose or throat

Other side effects of Zetonna

Some side effects of ciclesonide nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• ear pain

For healthcare professionals

Applies to ciclesonide nasal: nasal aerosol, nasal spray.

General adverse events

The most commonly reported side effects were headache, epistaxis, nasopharyngitis, and ear pain.^[Ref]

Endocrine

• Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis effects^[Ref]

Immunologic

• Common (1% to 10%): Influenza
• Frequency not reported: Candida albicans infections, immunosuppression^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity reactions (angioedema with swelling of the lips, tongue, and pharynx)^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, pharyngolaryngeal pain, sinusitis, nasal discomfort, cough, bronchitis, epistaxis
• Frequency not reported: Nasal dryness, nasal mucosal/septum disorders, pharyngitis, streptococcal pharyngitis, tonsillitis, nasal septal perforations
• Postmarketing reports: Nasal congestion, nasal ulcer^[Ref]

Ocular

• Postmarketing reports: Development or worsening of lens opacities, increase in intraocular pressure, worsening visual acuity^[Ref]

Other

• Common (1% to 10%): Ear pain
• Frequency not reported: Impaired wound healing, ear infection^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Frequency not reported: Sinus headache
• Postmarketing reports: Dizziness^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, muscle strain^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Further information

Zetonna side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer