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Zaltrap Side Effects

Generic name: ziv-aflibercept

Medically reviewed by Drugs.com. Last updated on Jun 19, 2024.

Note: This document provides detailed information about Zaltrap.

Applies to ziv-aflibercept: intravenous solution Side Effects associated with ziv-aflibercept. Some dosage forms listed on this page may not apply specifically to the brand name Zaltrap.

Applies to ziv-aflibercept: intravenous solution.

Precautions

Your doctor will want to check your progress at regular visits to see if the medicine is working properly and to decide if you should continue to receive it.

Your doctor will check your blood, urine, and blood pressure on a regular basis while you are receiving this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your normal blood pressure, call your doctor right away.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 1 month after the last dose. If you think you have become pregnant, tell your doctor right away.

This medicine may increase your chance of having bleeding problems. Call your doctor right away if you notice any signs of bleeding, such as bloody or black, tarry stools, blood in the urine, lightheadedness, shortness of breath, or vomiting of blood that looks like coffee grounds.

Call your doctor right away if you have severe diarrhea, nausea, vomiting, or stomach pain. These may be symptoms of a serious stomach problem.

This medicine may affect the way your body heals from cuts and wounds. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several weeks before having surgery.

This medicine may increase your risk of having blood clots. Check with your doctor right away if you have severe headaches of sudden onset, sudden loss of coordination, pains in the chest, groin, or legs, especially calves of legs, sudden onset of shortness of breath for no apparent reason, sudden onset of slurred speech, or sudden vision changes.

Check with your doctor right away if you have a headache, seizures, confusion, blurred vision or other visual problems. These may be symptoms of a rare and serious brain condition called reversible posterior leukoencephalopathy syndrome (RPLS).

Ziv-aflibercept can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

If you plan to have children, talk with your doctor before using this medicine. Some men and women using this medicine have become infertile (unable to have children).

Serious side effects of Zaltrap

Along with its needed effects, ziv-aflibercept (the active ingredient contained in Zaltrap) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv-aflibercept:

More common side effects

  • anxiety
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • blurred vision
  • chest pain
  • confusion
  • cough or hoarseness
  • decreased urination
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • dry mouth
  • excessive thirst
  • fainting
  • fever or chills
  • frequent urge to urinate
  • headache
  • hoarseness
  • lower back or side pain
  • nervousness
  • pain or swelling around the rectum
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • slow or fast heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden shortness of breath or troubled breathing
  • sunken eyes
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • wrinkled skin

Less common side effects

  • pains in the chest, groin, or legs, especially calves of the legs
  • severe headaches of sudden onset
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • troubled breathing

Rare side effects

  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • vomiting of material that looks like coffee grounds, severe and continuing

Incidence not known

  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • weight gain

Other side effects of Zaltrap

Some side effects of ziv-aflibercept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • lack or loss of strength
  • redness, swelling, or pain of the skin
  • runny nose
  • scaling of the skin on the hands and feet
  • swelling or inflammation of the mouth
  • tingling of the hands and feet
  • ulceration of the skin

Incidence not known

  • heavy jaw feeling
  • loosening of a tooth
  • pain, swelling, or numbness in the mouth or jaw

For healthcare professionals

Applies to ziv-aflibercept: intravenous solution.

Cardiovascular adverse events

Dermatologic

Gastrointestinal

Genitourinary

Hematologic

Hypersensitivity

Immunologic

Metabolic

Nervous system

Other

Renal

Respiratory

Hepatic

See also:

References

1. (2012) "Product Information. Zaltrap (ziv-aflibercept)." sanofi-aventis

Further information

Zaltrap side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.