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Zaltrap Side Effects

Generic Name: ziv-aflibercept

Note: This document contains side effect information about ziv-aflibercept. Some of the dosage forms listed on this page may not apply to the brand name Zaltrap.

For the Consumer

Applies to ziv-aflibercept: intravenous solution

Along with its needed effects, ziv-aflibercept (the active ingredient contained in Zaltrap) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv-aflibercept:

More Common

  • Anxiety
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • blurred vision
  • chest pain
  • confusion
  • cough or hoarseness
  • decreased urination
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • dry mouth
  • excessive thirst
  • fainting
  • fever or chills
  • frequent urge to urinate
  • headache
  • hoarseness
  • lower back or side pain
  • nervousness
  • pain or swelling around the rectum
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • slow or fast heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden shortness of breath or troubled breathing
  • sunken eyes
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • wrinkled skin

Some side effects of ziv-aflibercept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • lack or loss of strength
  • redness, swelling, or pain of the skin
  • runny nose
  • scaling of the skin on the hands and feet
  • swelling or inflammation of the mouth
  • tingling of the hands and feet
  • ulceration of the skin

For Healthcare Professionals

Applies to ziv-aflibercept: intravenous solution


Cardiovascular side effects have included hypertension (41%), deep vein thrombosis (9%), and angina pectoris.[Ref]


Dermatologic side effects have included palmar-plantar erythrodysesthesia syndrome (11%), skin hyperpigmentation (11%), compromised wound healing (0.3%), and catheter site infection.[Ref]


Gastrointestinal side effects have included diarrhea (69%), stomatitis (50%), abdominal pain (27%), abdominal pain upper (11%), hemorrhoids (6%), rectal hemorrhage (5%), proctalgia (5%), gastrointestinal hemorrhage (3%), fistulas formation (1.5%), gastrointestinal perforation (0.8%), and tooth infection.[Ref]


General side effects have included fatigue (48%) and asthenia (18%).[Ref]


Genitourinary side effects have included urinary tract infections (9%) and hematuria (3%).[Ref]


Hematologic side effects have included leukopenia (78%), neutropenia (67%), and thrombocytopenia (48%).[Ref]


Hypersensitivity reactions have included severe hypersensitivity reactions (0.3%).[Ref]


Immunologic side effects have included the development of anti-product antibody (3.1%).[Ref]


Metabolic side effects have included decreased appetite (32%), decreased weight (32%), and dehydration (9%).

Laboratory abnormalities have included increased AST (62%) and increase ALT (50%).[Ref]

Nervous system

Nervous system side effects have included headache (22%), reversible posterior leukoencephalopathy syndrome (0.5%), transient ischemic attack, and cerebrovascular accident.[Ref]


Other side effects have included post-procedural hemorrhage (3%).[Ref]


Renal side effects have included proteinuria (62%), increased serum creatinine (23%), and nephrotic syndrome (0.5%).[Ref]


Respiratory side effects have included epistaxis (28%), dysphonia (25%), dyspnea (12%), oropharyngeal pain (8%), rhinorrhea (6%), pulmonary embolism (5%), pulmonary hemorrhage, hemoptysis, nasopharyngitis, upper respiratory tract infection, and pneumonia.[Ref]


1. "Product Information. Zaltrap (ziv-aflibercept)." sanofi-aventis , Bridgewater, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.