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Welchol Side Effects

Generic name: colesevelam

Medically reviewed by Drugs.com. Last updated on Jun 9, 2024.

Note: This document provides detailed information about Welchol Side Effects associated with colesevelam. Some dosage forms listed on this page may not apply specifically to the brand name Welchol.

Applies to colesevelam: oral powder for suspension, oral tablet.

Serious side effects of Welchol

Along with its needed effects, colesevelam (the active ingredient contained in Welchol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colesevelam:

More common side effects

  • acid or sour stomach
  • belching
  • bloating
  • constipation
  • fever
  • headache
  • heartburn
  • indigestion
  • muscle aches
  • sore throat
  • stomach pain or discomfort
  • unusual tiredness or weakness

Less common side effects

  • anxiety
  • blurred vision
  • body aches or pain
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • cough
  • depression
  • diarrhea
  • difficulty in breathing
  • difficulty in moving
  • dizziness
  • dry or sore throat
  • ear congestion
  • general feeling of discomfort or illness
  • hoarseness
  • increased hunger
  • joint pain or swelling
  • loss of appetite
  • loss of consciousness
  • loss of voice
  • muscle pains, cramps, or stiffness
  • nausea
  • nervousness
  • nightmares
  • pounding in the ears
  • seizures
  • shakiness
  • shivering
  • slow or fast heartbeat
  • slurred speech
  • sneezing
  • stuffy or runny nose
  • sweating
  • tender, swollen glands in the neck
  • trouble with sleeping
  • trouble with swallowing
  • voice changes
  • vomiting

Incidence not known

  • bleeding after defecation
  • dark urine
  • pain or discomfort in the chest
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • swelling of the stomach area
  • unable to swallow saliva
  • uncomfortable swelling around the anus
  • yellow eyes or skin

Other side effects of Welchol

Some side effects of colesevelam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • accidental injury
  • back pain
  • lack or loss of strength

For healthcare professionals

Applies to colesevelam: oral powder for reconstitution, oral tablet.

General adverse events

The most frequently reported side effects were constipation, dyspepsia, and nausea.[Ref]

Gastrointestinal

Metabolic

Cardiovascular

Respiratory

Other

Musculoskeletal

Nervous system

Hypersensitivity

In clinical trials of type 2 diabetes, patient who received this drug as an add on to a sulfonylurea discontinued the trial due to body rash and mouth blistering that occurred on the first day of therapy.[Ref]

Hematologic

Hepatic

Endocrine

References

1. (2001) "Product Information. Welchol (colesevelam)." Daiichi Sankyo, Inc.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Welchol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.