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Wal-Zyr D Side Effects

Generic Name: cetirizine / pseudoephedrine

Note: This page contains side effects data for the generic drug cetirizine / pseudoephedrine. It is possible that some of the dosage forms included below may not apply to the brand name Wal-Zyr D.

In Summary

More frequent side effects include: insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cetirizine / pseudoephedrine: oral tablet extended release

As well as its needed effects, cetirizine / pseudoephedrine may cause unwanted side effects that require medical attention.

If any of the following symptoms of overdose occur while taking cetirizine / pseudoephedrine, get emergency help immediately:

Symptoms of overdose:
  • Changes in mood, irrational behavior, depersonalization hallucinations
  • convulsions (seizures)
  • extreme sleepiness or unusual drowsiness
  • fast, slow, pounding, or irregular heartbeat or pulse
  • feeling anxious
  • giddiness
  • headache
  • irritability
  • muscle weakness or tenderness
  • nausea
  • restlessness
  • shallow, irregular, fast, or slow breathing
  • sleeplessness or trouble in sleeping
  • abdominal and/or chest pain
  • thirst

Severity: Moderate

If any of the following side effects occur while taking cetirizine / pseudoephedrine, check with your doctor or nurse as soon as possible:

  • Breathing, troubled
  • back, leg, or stomach pain
  • blurred vision
  • bloody, cloudy, or dark urine, sudden decrease in amount of urine
  • black, tarry stools, diarrhea, light-colored stools
  • confusion
  • dizziness, feeling faint, or lightheaded
  • fever or chills
  • increased blood pressure
  • rapid weight gain
  • skin rash or hives
  • swelling of face, mouth, throat, fingers, glands, feet, and/or lower legs
  • stillbirth
  • twitching, twisting, or uncontrolled repetitive movements of the face
  • sudden sweating
  • vomiting blood, bleeding gums, nosebleeds, unusual bleeding or bruising
  • pale or yellow eyes or skin
  • unusual tiredness or weakness

Minor Side Effects

Some cetirizine / pseudoephedrine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Sleepiness or unusual drowsiness, extreme tiredness
Less common:
  • Dry mouth
  • weakness
  • Dizziness
  • sore throat

For Healthcare Professionals

Applies to cetirizine / pseudoephedrine: oral tablet extended release


Dermatologic side effects have included maculopapular and urticarial eruptions.[Ref]


Gastrointestinal side effects of cetirizine have included dry mouth (5.7%) and nausea or vomiting (2.2%). Pharyngitis, dyspepsia, and increased appetite have occasionally been reported.

Gastrointestinal adverse effects of pseudoephedrine have included anorexia and gastric irritation (5%). Dry mouth, nose, or throat have occurred in up to 15% of patients.[Ref]


Hepatic side effects have included rare liver function test abnormalities which resolved spontaneously following discontinuation of cetirizine therapy.[Ref]

Nervous system

Cetirizine appears to be more sedating than terfenadine, astemizole, and loratadine.[Ref]

Nervous system side effects of cetirizine administration have included headache (16%), fatigue (5.6%), and somnolence (5% to 20%). Somnolence tends to be dose-related and generally occurs more frequently with doses higher than 10 mg per day. Other nervous system side effects include dizziness (1.8%), insomnia (1.5%), and nervousness (1.1%). Post marketing reports have included aggression reaction and convulsions.

Nervous system side effects of pseudoephedrine have included insomnia in up to 30% of patients. Tremor, anxiety, nervousness, and headache have also been reported.[Ref]


Respiratory side effects have included wheezing, coughing, bronchitis, sinusitis, and asthma.[Ref]


Hypersensitivity reactions have included fixed drug eruptions with pseudoephedrine use.[Ref]


Cardiovascular side effects have included tachycardia. Some patients have developed hypertension and/or arrhythmias.[Ref]


General side effects have included epistaxis (1.1%) and accidental injury (1.1%).[Ref]


1. "Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.

It is possible that some side effects of Wal-Zyr D may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Wal-Zyr D (cetirizine / pseudoephedrine)

Consumer resources

Other brands: Zyrtec-D, Zyrtec-D 12 Hour, All Day Allergy-D

Professional resources

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