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Vincristine liposome Side Effects

In Summary

Commonly reported side effects of vincristine liposome include: anemia, constipation, neutropenia, and thrombocytopenia. Other side effects include: asthenia, increased serum aspartate aminotransferase, and intestinal obstruction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vincristine liposome: intravenous solution, intravenous suspension

Along with its needed effects, vincristine liposome may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:

More Common

  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • change in consciousness
  • change in muscle reflexes
  • chest pain
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • increased sensitivity to pain or touch
  • low blood pressure or pulse
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sensation of pins and needles
  • severe constipation
  • severe vomiting
  • shortness of breath
  • sneezing
  • sore throat
  • stabbing pain
  • sweating
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less Common

  • Blue lips, fingernails, or skin
  • irregular, fast or slow, or shallow breathing

Incidence Not Known

  • Abdominal or stomach tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • yellow eyes or skin

Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

Incidence Not Known

  • Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit

Cardiovascular

Frequency not reported: Hypotension, cardiac arrest[Ref]

Gastrointestinal

Very common (10% or more): Constipation (57%), nausea (52%), diarrhea (37%), decreased appetite (33%)

Frequency not reported: Abdominal pain, ileus/colonic pseudo-obstruction[Ref]

General

Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death[Ref]

Hematologic

Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)

Frequency not reported: Neutropenia, thrombocytopenia, Tumor lysis syndrome[Ref]

Metabolic

Frequency not reported: Increased aspartate aminotransferase[Ref]

Musculoskeletal

Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)

Frequency not reported: Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia[Ref]

Other

Very common (10% or more): Pyrexia (43%), fatigue (41%)

Frequency not reported: Pain, septic shock, staphylococcal bacteremia[Ref]

Psychiatric

Frequency not reported: Mental status changes[Ref]

Respiratory

Frequency not reported: Pneumonia, respiratory distress, respiratory failure[Ref]

References

1. "Product Information. Marqibo (vinCRIStine liposome)." Talon Therapeutics Inc, South San Francisco,, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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