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Vincristine liposome Side Effects

In Summary

Commonly reported side effects of vincristine liposome include: anemia, constipation, neutropenia, and thrombocytopenia. Other side effects include: increased serum aspartate aminotransferase, intestinal obstruction, and weakness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vincristine liposome: intravenous solution, intravenous suspension

As well as its needed effects, vincristine liposome may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking vincristine liposome, check with your doctor or nurse immediately:

More common:
  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • change in consciousness
  • change in muscle reflexes
  • chest pain
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • increased sensitivity to pain or touch
  • low blood pressure or pulse
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sensation of pins and needles
  • severe constipation
  • severe vomiting
  • shortness of breath
  • sneezing
  • sore throat
  • stabbing pain
  • sweating
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Blue lips, fingernails, or skin
  • irregular, fast or slow, or shallow breathing
Incidence not known:
  • Abdominal or stomach tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • yellow eyes or skin

Minor Side Effects

Some vincristine liposome side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Lack or loss of strength
  • mental depression or anxiety
  • muscle weakness
  • nightmares or unusually vivid dreams
Incidence not known:
  • Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit

Cardiovascular

Frequency not reported: Hypotension, cardiac arrest[Ref]

Gastrointestinal

Very common (10% or more): Constipation (57%), nausea (52%), diarrhea (37%), decreased appetite (33%)
Frequency not reported: Abdominal pain, ileus/colonic pseudo-obstruction[Ref]

General

Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death[Ref]

Hematologic

Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)
Frequency not reported: Neutropenia, thrombocytopenia, Tumor lysis syndrome[Ref]

Metabolic

Frequency not reported: Increased aspartate aminotransferase[Ref]

Musculoskeletal

Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)
Frequency not reported: Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia[Ref]

Other

Very common (10% or more): Pyrexia (43%), fatigue (41%)
Frequency not reported: Pain, septic shock, staphylococcal bacteremia[Ref]

Psychiatric

Frequency not reported: Mental status changes[Ref]

Respiratory

Frequency not reported: Pneumonia, respiratory distress, respiratory failure[Ref]

References

1. "Product Information. Marqibo (vinCRIStine liposome)." Talon Therapeutics Inc, South San Francisco,, CA.

It is possible that some side effects of vincristine liposome may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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