Generic Name: vincristine liposome (vin KRIS teen LYE poe some)
Brand Name: Marqibo
Medically reviewed on August 6, 2018
What is vincristine liposome?
Vincristine liposome is cancer medication that interferes with the growth of cancer cells and slows their spread in the body.
Vincristine liposome is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL).
Vincristine liposome is usually given after at least two other cancer medications have been tried without success.
Vincristine liposome may also be used for purposes not listed in this medication guide.
You should not use this medication if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
Before taking this medicine
You should not use this medication if you are allergic to vincristine, or if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
To make sure vincristine liposome is safe for you, tell your doctor if you have:
Vincristine liposome can cause harm to an unborn baby or cause birth defects. Before you receive vincristine liposome, tell your doctor if you are pregnant. Use effective birth control to avoid pregnancy during your treatment with vincristine liposome. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
Vincristine liposome can pass into breast milk and may harm a nursing baby. You should not breast-feed while using vincristine liposome.
How is vincristine liposome given?
Vincristine liposome is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion.
Vincristine liposome can cause severe constipation. You may be given medication to prevent constipation while you are receiving this medicine. Use all medications as directed by your doctor.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
Vincristine liposome can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your vincristine liposome injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving vincristine liposome?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using vincristine liposome, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
vincristine liposome can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Vincristine liposome side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe constipation, severe cramps;
pale skin, feeling light-headed or short of breath, rapid heart rate, feeling very weak or tired;
numbness, tingling, or burning pain in your hands or feet;
fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
lower back pain, blood in your urine, little or no urinating;
tingly feeling around your mouth, muscle weakness, tightness, or contraction, overactive reflexes;
fast or slow heart rate, weak pulse, confusion, fainting; or
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Vincristine liposome dosing information
Usual Adult Dose for Acute Lymphoblastic Leukemia:
2.25 mg/m2 IV over 1 hour once every 7 days
Use: Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies. This indication is based on overall response rate. Clinical benefit such as improvement in overall survival has not been verified.
What other drugs will affect vincristine liposome?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with vincristine liposome, especially:
an antibiotic--clarithromycin, erythromycin, telithromycin; antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole; HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir; hepatitis C medications--boceprevir, telaprevir.
This list is not complete. Other drugs may interact with vincristine liposome, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.02.
More about vincristine liposome
- Vincristine liposome Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: mitotic inhibitors
Other brands: Marqibo