Tryvio Side Effects
Generic name: aprocitentan
Medically reviewed by Drugs.com. Last updated on Jun 10, 2025.
Note: This document provides detailed information about Tryvio Side Effects associated with aprocitentan. Some dosage forms listed on this page may not apply specifically to the brand name Tryvio.
Applies to aprocitentan: oral tablets film-coated.
Important warnings
This medicine can cause some serious health issues
-
Fetal/Neonatal Morbidity and Mortality
- Based on animal data, may cause fetal harm during pregnancy.1
- Exclude pregnancy in females of childbearing potential prior to treatment initiation and prevent thereafter by using acceptable methods of contraception during and for 1 month after discontinuation of therapy.1
- When pregnancy is detected, discontinue aprocitentan as soon as possible.1
Side effects include:
Adverse effects reported in ≥2% of patients receiving aprocitentan (the active ingredient contained in Tryvio) include edema/fluid retention and anemia.
See also:
For healthcare professionals
Applies to aprocitentan: oral tablet.
General adverse events
The most frequently reported side effects included anemia, edema, and fluid retention.[Ref]
Dermatologic
- Frequency not reported: Allergic dermatitis, erythema, rash
Hematologic
- Common (1% to 10%): Anemia/decreased hemoglobin
- Frequency not reported: Decreased hematocrit
Hepatic
- Frequency not reported: Hepatotoxicity, increased aminotransferases, increased ALT, increased AST
Hypersensitivity
- Uncommon (0.1% to 1%): Hypersensitivity
- Frequency not reported: Allergic edema
Hypersensitivity included rash, erythema, and allergic edema.
Metabolic
- Common (1% to 10%): Edema/fluid retention
Renal
- Frequency not reported: Decrease in estimated GFR
References
1. (2024) "Product Information. Tryvio (aprocitentan)." Idorsia Pharmaceuticals US Inc.
More about Tryvio (aprocitentan)
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Further information
Tryvio side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
