Tositumomab Side Effects

Applies to tositumomab: intravenous kit

Cardiovascular

Common (1% to 10%): Hypotension, vasodilation^[Ref]

Dermatologic

Very common (10% or more): Rash, pruritus
Common (1% to 10%): Sweating^[Ref]

Endocrine

Common (1% to 10%): Hypothyroidism^[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain, nausea, vomiting, diarrhea, anorexia
Common (1% to 10%): Constipation, dyspepsia^[Ref]

Hematologic

Very common (10% or more): Neutropenia, thrombocytopenia, anemia^[Ref]

Hypersensitivity

Common (1% to 10%): Allergic (hypersensitivity) reactions (allergic reaction, facial edema, injection site hypersensitivity, anaphylactic reaction, laryngismus, serum sickness)
Postmarketing reports: Hypersensitivity reactions including fatal anaphylaxis^[Ref]

Immunologic

Very common (10% or more): Positive serology for human anti-mouse antibodies (HAMA)^[Ref]

Local

Frequency not reported: Infusion reactions^[Ref]

Metabolic

Common (1% to 10%): Peripheral edema, weight loss^[Ref]

Musculoskeletal

Very common (10% or more): Myalgia, arthralgia
Common (1% to 10%): Back pain, neck pain^[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence
Postmarketing reports: Axonal neuropathy leading to quadriparesis^[Ref]

Oncologic

Common (1% to 10%): Secondary malignancies (non-melanoma skin, colorectal, head and neck, breast, lung, bladder, melanoma, gastric)
Frequency not reported: Secondary leukemia, myelodysplastic syndrome^[Ref]

Other

Very common (10% or more): Asthenia, fever, infections, pain, chills, headache
Common (1% to 10%): Chest pain, serious infections (pneumonia, bacteremia, septicemia, bronchitis, skin infections)^[Ref]

Respiratory

Very common (10% or more): Cough, pharyngitis, dyspnea, rhinitis
Common (1% to 10%): Pneumonia^[Ref]

Some side effects of tositumomab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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