Tositumomab Side Effects
Applies to tositumomab: intravenous kit
Cardiovascular
Common (1% to 10%): Hypotension, vasodilation[Ref]
Dermatologic
Very common (10% or more): Rash, pruritus
Common (1% to 10%): Sweating[Ref]
Endocrine
Common (1% to 10%): Hypothyroidism[Ref]
Gastrointestinal
Very common (10% or more): Abdominal pain, nausea, vomiting, diarrhea, anorexia
Common (1% to 10%): Constipation, dyspepsia[Ref]
Hematologic
Very common (10% or more): Neutropenia, thrombocytopenia, anemia[Ref]
Hypersensitivity
Common (1% to 10%): Allergic (hypersensitivity) reactions (allergic reaction, facial edema, injection site hypersensitivity, anaphylactic reaction, laryngismus, serum sickness)
Postmarketing reports: Hypersensitivity reactions including fatal anaphylaxis[Ref]
Immunologic
Very common (10% or more): Positive serology for human anti-mouse antibodies (HAMA)[Ref]
Local
Frequency not reported: Infusion reactions[Ref]
Metabolic
Common (1% to 10%): Peripheral edema, weight loss[Ref]
Musculoskeletal
Very common (10% or more): Myalgia, arthralgia
Common (1% to 10%): Back pain, neck pain[Ref]
Nervous system
Common (1% to 10%): Dizziness, somnolence
Postmarketing reports: Axonal neuropathy leading to quadriparesis[Ref]
Oncologic
Common (1% to 10%): Secondary malignancies (non-melanoma skin, colorectal, head and neck, breast, lung, bladder, melanoma, gastric)
Frequency not reported: Secondary leukemia, myelodysplastic syndrome[Ref]
Other
Very common (10% or more): Asthenia, fever, infections, pain, chills, headache
Common (1% to 10%): Chest pain, serious infections (pneumonia, bacteremia, septicemia, bronchitis, skin infections)[Ref]
Respiratory
Very common (10% or more): Cough, pharyngitis, dyspnea, rhinitis
Common (1% to 10%): Pneumonia[Ref]
References
1. "Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab)." GlaxoSmithKline, Research Triangle Park, NC.
2. "Product Information. BexxarTherapy (tositumomab)." GlaxoSmithKline Inc, Oakville, IA.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
